Cargando…

Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining

Secretory carcinoma is a salivary gland neoplasm first described as a mammary analogue secretory carcinoma by Skalova and redesignated as a secretory carcinoma in the 2017 World Health Organization Classification of Head and Neck Tumors. Secretory carcinoma diagnosis is reliant on specific cytologic...

Descripción completa

Detalles Bibliográficos
Autores principales: Egusa, Yuria, Nishimura, Midori Filiz, Baba, Satoko, Takeuchi, Kengo, Makino, Takuma, Tachibana, Tomoyasu, Nishikori, Asami, Fujita, Azusa, Yanai, Hiroyuki, Sato, Yasuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700047/
https://www.ncbi.nlm.nih.gov/pubmed/34943521
http://dx.doi.org/10.3390/diagnostics11122284
_version_ 1784620661774221312
author Egusa, Yuria
Nishimura, Midori Filiz
Baba, Satoko
Takeuchi, Kengo
Makino, Takuma
Tachibana, Tomoyasu
Nishikori, Asami
Fujita, Azusa
Yanai, Hiroyuki
Sato, Yasuharu
author_facet Egusa, Yuria
Nishimura, Midori Filiz
Baba, Satoko
Takeuchi, Kengo
Makino, Takuma
Tachibana, Tomoyasu
Nishikori, Asami
Fujita, Azusa
Yanai, Hiroyuki
Sato, Yasuharu
author_sort Egusa, Yuria
collection PubMed
description Secretory carcinoma is a salivary gland neoplasm first described as a mammary analogue secretory carcinoma by Skalova and redesignated as a secretory carcinoma in the 2017 World Health Organization Classification of Head and Neck Tumors. Secretory carcinoma diagnosis is reliant on specific cytological and histological findings and the detection of an ETV6-NTRK3 fusion gene. Here, we examined the clinical and cytopathological features of four cases of secretory carcinoma occurring in three males and a female, aged between 39 and 74 years. All four tumors involved the parotid gland, and were found to have the ETV6-NTRK3 fusion gene. Fine-needle aspiration-based cytology smears of all tumors displayed papillary and/or dendritic pattern clusters, some of which were associated with blood vessels. The neoplastic cells displayed enlarged nuclei with fine chromatin and small, distinct, single nucleoli. Furthermore, several neoplastic cells with a characteristic vacuolated cytoplasm were identified in each specimen. Giemsa staining revealed cytoplasmic vacuolation, intracytoplasmic metachromatic secretions and/or various sized metachromatic granules, and a background of metachromatic mucin in all four specimens. Given this, we conclude that these cytological findings, especially those of the Giemsa staining, might be helpful in the diagnosis of secretory carcinoma.
format Online
Article
Text
id pubmed-8700047
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87000472021-12-24 Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining Egusa, Yuria Nishimura, Midori Filiz Baba, Satoko Takeuchi, Kengo Makino, Takuma Tachibana, Tomoyasu Nishikori, Asami Fujita, Azusa Yanai, Hiroyuki Sato, Yasuharu Diagnostics (Basel) Article Secretory carcinoma is a salivary gland neoplasm first described as a mammary analogue secretory carcinoma by Skalova and redesignated as a secretory carcinoma in the 2017 World Health Organization Classification of Head and Neck Tumors. Secretory carcinoma diagnosis is reliant on specific cytological and histological findings and the detection of an ETV6-NTRK3 fusion gene. Here, we examined the clinical and cytopathological features of four cases of secretory carcinoma occurring in three males and a female, aged between 39 and 74 years. All four tumors involved the parotid gland, and were found to have the ETV6-NTRK3 fusion gene. Fine-needle aspiration-based cytology smears of all tumors displayed papillary and/or dendritic pattern clusters, some of which were associated with blood vessels. The neoplastic cells displayed enlarged nuclei with fine chromatin and small, distinct, single nucleoli. Furthermore, several neoplastic cells with a characteristic vacuolated cytoplasm were identified in each specimen. Giemsa staining revealed cytoplasmic vacuolation, intracytoplasmic metachromatic secretions and/or various sized metachromatic granules, and a background of metachromatic mucin in all four specimens. Given this, we conclude that these cytological findings, especially those of the Giemsa staining, might be helpful in the diagnosis of secretory carcinoma. MDPI 2021-12-07 /pmc/articles/PMC8700047/ /pubmed/34943521 http://dx.doi.org/10.3390/diagnostics11122284 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Egusa, Yuria
Nishimura, Midori Filiz
Baba, Satoko
Takeuchi, Kengo
Makino, Takuma
Tachibana, Tomoyasu
Nishikori, Asami
Fujita, Azusa
Yanai, Hiroyuki
Sato, Yasuharu
Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
title Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
title_full Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
title_fullStr Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
title_full_unstemmed Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
title_short Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
title_sort cytopathological findings of secretory carcinoma of the salivary gland and the diagnostic utility of giemsa staining
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700047/
https://www.ncbi.nlm.nih.gov/pubmed/34943521
http://dx.doi.org/10.3390/diagnostics11122284
work_keys_str_mv AT egusayuria cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining
AT nishimuramidorifiliz cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining
AT babasatoko cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining
AT takeuchikengo cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining
AT makinotakuma cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining
AT tachibanatomoyasu cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining
AT nishikoriasami cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining
AT fujitaazusa cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining
AT yanaihiroyuki cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining
AT satoyasuharu cytopathologicalfindingsofsecretorycarcinomaofthesalivaryglandandthediagnosticutilityofgiemsastaining