Cargando…

Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme

Most endocervical adenocarcinomas (EAC) are associated with high-risk HPV (hrHPV) infection, with HPV genotypes 16, 18 and 45 accounting for >90% of the cases. Among endocervical glandular lesions, screening with hrHPV test has previously shown to predict the outcome better than cytology, althoug...

Descripción completa

Detalles Bibliográficos
Autores principales: Pulkkinen, Johanna, Kares, Saara, Huhtala, Heini, Kholová, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700048/
https://www.ncbi.nlm.nih.gov/pubmed/34943636
http://dx.doi.org/10.3390/diagnostics11122402
_version_ 1784620662031122432
author Pulkkinen, Johanna
Kares, Saara
Huhtala, Heini
Kholová, Ivana
author_facet Pulkkinen, Johanna
Kares, Saara
Huhtala, Heini
Kholová, Ivana
author_sort Pulkkinen, Johanna
collection PubMed
description Most endocervical adenocarcinomas (EAC) are associated with high-risk HPV (hrHPV) infection, with HPV genotypes 16, 18 and 45 accounting for >90% of the cases. Among endocervical glandular lesions, screening with hrHPV test has previously shown to predict the outcome better than cytology, although around one-fifth of the EAC remain negative both in hrHPV testing and cytology. The study consists of two consecutive HPV-primary screening rounds, conducted in 2012–2015 and 2017–2020. Of the 87 women aged 35 to 60 years of age diagnosed with Atypical endocervical cells, NOS or Atypical endocervical cells, favor neoplastic cytology during the first screening round, 63 (72.4%) were hrHPV positive and 24 (27.6%) were hrHPV negative. Among hrHPV positive patients, three EAC, two adenocarcinomas in situ (AIS), one AIS + high-grade intraepithelial lesion (HSIL) and 13 HSIL were found. Of the histologically verified lesions, 68.4% (13/19) were purely of squamous origin. All the EAC and AIS were HPV16 or HPV 18 positive. No high-grade histological lesions were found among the hrHPV negative patients with cytological glandular atypia. A later database search revealed one HPV-negative, gastric-type mucinous EAC that was missed by the HPV primary screening.
format Online
Article
Text
id pubmed-8700048
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87000482021-12-24 Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme Pulkkinen, Johanna Kares, Saara Huhtala, Heini Kholová, Ivana Diagnostics (Basel) Article Most endocervical adenocarcinomas (EAC) are associated with high-risk HPV (hrHPV) infection, with HPV genotypes 16, 18 and 45 accounting for >90% of the cases. Among endocervical glandular lesions, screening with hrHPV test has previously shown to predict the outcome better than cytology, although around one-fifth of the EAC remain negative both in hrHPV testing and cytology. The study consists of two consecutive HPV-primary screening rounds, conducted in 2012–2015 and 2017–2020. Of the 87 women aged 35 to 60 years of age diagnosed with Atypical endocervical cells, NOS or Atypical endocervical cells, favor neoplastic cytology during the first screening round, 63 (72.4%) were hrHPV positive and 24 (27.6%) were hrHPV negative. Among hrHPV positive patients, three EAC, two adenocarcinomas in situ (AIS), one AIS + high-grade intraepithelial lesion (HSIL) and 13 HSIL were found. Of the histologically verified lesions, 68.4% (13/19) were purely of squamous origin. All the EAC and AIS were HPV16 or HPV 18 positive. No high-grade histological lesions were found among the hrHPV negative patients with cytological glandular atypia. A later database search revealed one HPV-negative, gastric-type mucinous EAC that was missed by the HPV primary screening. MDPI 2021-12-20 /pmc/articles/PMC8700048/ /pubmed/34943636 http://dx.doi.org/10.3390/diagnostics11122402 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pulkkinen, Johanna
Kares, Saara
Huhtala, Heini
Kholová, Ivana
Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme
title Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme
title_full Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme
title_fullStr Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme
title_full_unstemmed Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme
title_short Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme
title_sort detection and outcome of endocervical atypia in cytology in primary hpv screening programme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700048/
https://www.ncbi.nlm.nih.gov/pubmed/34943636
http://dx.doi.org/10.3390/diagnostics11122402
work_keys_str_mv AT pulkkinenjohanna detectionandoutcomeofendocervicalatypiaincytologyinprimaryhpvscreeningprogramme
AT karessaara detectionandoutcomeofendocervicalatypiaincytologyinprimaryhpvscreeningprogramme
AT huhtalaheini detectionandoutcomeofendocervicalatypiaincytologyinprimaryhpvscreeningprogramme
AT kholovaivana detectionandoutcomeofendocervicalatypiaincytologyinprimaryhpvscreeningprogramme