Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment

Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are t...

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Detalles Bibliográficos
Autores principales: Hernández, Ainhoa, Domènech, Marta, Muñoz-Mármol, Ana M., Carrato, Cristina, Balana, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700075/
https://www.ncbi.nlm.nih.gov/pubmed/34944036
http://dx.doi.org/10.3390/cells10123529
Descripción
Sumario:Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested.

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