Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment

Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are t...

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Detalles Bibliográficos
Autores principales: Hernández, Ainhoa, Domènech, Marta, Muñoz-Mármol, Ana M., Carrato, Cristina, Balana, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700075/
https://www.ncbi.nlm.nih.gov/pubmed/34944036
http://dx.doi.org/10.3390/cells10123529
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author Hernández, Ainhoa
Domènech, Marta
Muñoz-Mármol, Ana M.
Carrato, Cristina
Balana, Carmen
author_facet Hernández, Ainhoa
Domènech, Marta
Muñoz-Mármol, Ana M.
Carrato, Cristina
Balana, Carmen
author_sort Hernández, Ainhoa
collection PubMed
description Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested.
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spelling pubmed-87000752021-12-24 Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment Hernández, Ainhoa Domènech, Marta Muñoz-Mármol, Ana M. Carrato, Cristina Balana, Carmen Cells Review Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested. MDPI 2021-12-14 /pmc/articles/PMC8700075/ /pubmed/34944036 http://dx.doi.org/10.3390/cells10123529 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hernández, Ainhoa
Domènech, Marta
Muñoz-Mármol, Ana M.
Carrato, Cristina
Balana, Carmen
Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment
title Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment
title_full Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment
title_fullStr Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment
title_full_unstemmed Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment
title_short Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment
title_sort glioblastoma: relationship between metabolism and immunosuppressive microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700075/
https://www.ncbi.nlm.nih.gov/pubmed/34944036
http://dx.doi.org/10.3390/cells10123529
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AT carratocristina glioblastomarelationshipbetweenmetabolismandimmunosuppressivemicroenvironment
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