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Monocyte Subsets in Patients with Chronic Heart Failure Treated with Cardiac Resynchronization Therapy
Background: The exact role of individual inflammatory factor in heart failure with reduced ejection fraction (HFrEF) remains elusive. The study aimed to evaluate three monocyte subsets (classical-CD14(++)CD16(−), intermediate-CD14(++)CD16(+), and nonclassical-CD14(+)CD16(++)) in HFrEF patients and t...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700101/ https://www.ncbi.nlm.nih.gov/pubmed/34943990 http://dx.doi.org/10.3390/cells10123482 |
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author | Ptaszyńska-Kopczyńska, Katarzyna Eljaszewicz, Andrzej Marcinkiewicz-Siemion, Marta Sawicka-Śmiarowska, Emilia Tarasiuk, Ewa Lisowska, Anna Tynecka, Marlena Grubczak, Kamil Radzikowska, Urszula Janucik, Adrian Moniuszko, Marcin Charkiewicz, Karol Laudański, Piotr Sobkowicz, Bożena Kamiński, Karol A. |
author_facet | Ptaszyńska-Kopczyńska, Katarzyna Eljaszewicz, Andrzej Marcinkiewicz-Siemion, Marta Sawicka-Śmiarowska, Emilia Tarasiuk, Ewa Lisowska, Anna Tynecka, Marlena Grubczak, Kamil Radzikowska, Urszula Janucik, Adrian Moniuszko, Marcin Charkiewicz, Karol Laudański, Piotr Sobkowicz, Bożena Kamiński, Karol A. |
author_sort | Ptaszyńska-Kopczyńska, Katarzyna |
collection | PubMed |
description | Background: The exact role of individual inflammatory factor in heart failure with reduced ejection fraction (HFrEF) remains elusive. The study aimed to evaluate three monocyte subsets (classical-CD14(++)CD16(−), intermediate-CD14(++)CD16(+), and nonclassical-CD14(+)CD16(++)) in HFrEF patients and to assess the effect of the cardiac resynchronization therapy (CRT) on the changes in monocyte compartment. Methods: The study included 85 patients with stable HFrEF. Twenty-five of them underwent CRT device implantation with subsequent 6-month assessment. The control group consisted of 23 volunteers without HFrEF. Results: The analysis revealed that frequencies of non-classical-CD14(+)CD16(++) monocytes were lower in HFrEF patients compared to the control group (6.98 IQR: 4.95–8.65 vs. 8.37 IQR: 6.47–9.94; p = 0.021), while CD14(++)CD16(+) and CD14(++)CD16(−) did not differ. The analysis effect of CRT on the frequency of analysed monocyte subsets 6 months after CRT device implantation showed a significant increase in CD14(+)CD16(++) (from 7 IQR: 4.5–8.4 to 7.9 IQR: 6.5–9.5; p = 0.042) and CD14(++)CD16(+) (from 5.1 IQR: 3.7–6.5 to 6.8 IQR: 5.4–7.4; p = 0.017) monocytes, while the frequency of steady-state CD14(++)CD16(−) monocytes was decreased (from 81.4 IQR: 78–86.2 to 78.2 IQR: 76.1–81.7; p = 0.003). Conclusions: HFrEF patients present altered monocyte composition. CRT-related changes in the monocyte compartment achieve levels observed in controls without HFrEF. |
format | Online Article Text |
id | pubmed-8700101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87001012021-12-24 Monocyte Subsets in Patients with Chronic Heart Failure Treated with Cardiac Resynchronization Therapy Ptaszyńska-Kopczyńska, Katarzyna Eljaszewicz, Andrzej Marcinkiewicz-Siemion, Marta Sawicka-Śmiarowska, Emilia Tarasiuk, Ewa Lisowska, Anna Tynecka, Marlena Grubczak, Kamil Radzikowska, Urszula Janucik, Adrian Moniuszko, Marcin Charkiewicz, Karol Laudański, Piotr Sobkowicz, Bożena Kamiński, Karol A. Cells Article Background: The exact role of individual inflammatory factor in heart failure with reduced ejection fraction (HFrEF) remains elusive. The study aimed to evaluate three monocyte subsets (classical-CD14(++)CD16(−), intermediate-CD14(++)CD16(+), and nonclassical-CD14(+)CD16(++)) in HFrEF patients and to assess the effect of the cardiac resynchronization therapy (CRT) on the changes in monocyte compartment. Methods: The study included 85 patients with stable HFrEF. Twenty-five of them underwent CRT device implantation with subsequent 6-month assessment. The control group consisted of 23 volunteers without HFrEF. Results: The analysis revealed that frequencies of non-classical-CD14(+)CD16(++) monocytes were lower in HFrEF patients compared to the control group (6.98 IQR: 4.95–8.65 vs. 8.37 IQR: 6.47–9.94; p = 0.021), while CD14(++)CD16(+) and CD14(++)CD16(−) did not differ. The analysis effect of CRT on the frequency of analysed monocyte subsets 6 months after CRT device implantation showed a significant increase in CD14(+)CD16(++) (from 7 IQR: 4.5–8.4 to 7.9 IQR: 6.5–9.5; p = 0.042) and CD14(++)CD16(+) (from 5.1 IQR: 3.7–6.5 to 6.8 IQR: 5.4–7.4; p = 0.017) monocytes, while the frequency of steady-state CD14(++)CD16(−) monocytes was decreased (from 81.4 IQR: 78–86.2 to 78.2 IQR: 76.1–81.7; p = 0.003). Conclusions: HFrEF patients present altered monocyte composition. CRT-related changes in the monocyte compartment achieve levels observed in controls without HFrEF. MDPI 2021-12-09 /pmc/articles/PMC8700101/ /pubmed/34943990 http://dx.doi.org/10.3390/cells10123482 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ptaszyńska-Kopczyńska, Katarzyna Eljaszewicz, Andrzej Marcinkiewicz-Siemion, Marta Sawicka-Śmiarowska, Emilia Tarasiuk, Ewa Lisowska, Anna Tynecka, Marlena Grubczak, Kamil Radzikowska, Urszula Janucik, Adrian Moniuszko, Marcin Charkiewicz, Karol Laudański, Piotr Sobkowicz, Bożena Kamiński, Karol A. Monocyte Subsets in Patients with Chronic Heart Failure Treated with Cardiac Resynchronization Therapy |
title | Monocyte Subsets in Patients with Chronic Heart Failure Treated with Cardiac Resynchronization Therapy |
title_full | Monocyte Subsets in Patients with Chronic Heart Failure Treated with Cardiac Resynchronization Therapy |
title_fullStr | Monocyte Subsets in Patients with Chronic Heart Failure Treated with Cardiac Resynchronization Therapy |
title_full_unstemmed | Monocyte Subsets in Patients with Chronic Heart Failure Treated with Cardiac Resynchronization Therapy |
title_short | Monocyte Subsets in Patients with Chronic Heart Failure Treated with Cardiac Resynchronization Therapy |
title_sort | monocyte subsets in patients with chronic heart failure treated with cardiac resynchronization therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700101/ https://www.ncbi.nlm.nih.gov/pubmed/34943990 http://dx.doi.org/10.3390/cells10123482 |
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