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Mouse Organ-Specific Proteins and Functions
Organ-specific proteins (OSPs) possess great medical potential both in clinics and in biomedical research. Applications of them—such as alanine transaminase, aspartate transaminase, and troponins—in clinics have raised certain concerns of their organ specificity. The dynamics and diversity of protei...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700158/ https://www.ncbi.nlm.nih.gov/pubmed/34943957 http://dx.doi.org/10.3390/cells10123449 |
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author | Sun, Bingyun Lorang, Cynthia Qin, Shizhen Zhang, Yijuan Liu, Ken Li, Gray Sun, Zhi Francke, Ashley Utleg, Angelita G. Hu, Zhiyuan Wang, Kai Moritz, Robert L. Hood, Leroy |
author_facet | Sun, Bingyun Lorang, Cynthia Qin, Shizhen Zhang, Yijuan Liu, Ken Li, Gray Sun, Zhi Francke, Ashley Utleg, Angelita G. Hu, Zhiyuan Wang, Kai Moritz, Robert L. Hood, Leroy |
author_sort | Sun, Bingyun |
collection | PubMed |
description | Organ-specific proteins (OSPs) possess great medical potential both in clinics and in biomedical research. Applications of them—such as alanine transaminase, aspartate transaminase, and troponins—in clinics have raised certain concerns of their organ specificity. The dynamics and diversity of protein expression in heterogeneous human populations are well known, yet their effects on OSPs are less addressed. Here, we used mice as a model and implemented a breadth study to examine the panorgan proteome for potential variations in organ specificity in different genetic backgrounds. Using reasonable resources, we generated panorgan proteomes of four in-bred mouse strains. The results revealed a large diversity that was more profound among OSPs than among proteomes overall. We defined a robustness score to quantify such variation and derived three sets of OSPs with different stringencies. In the meantime, we found that the enriched biological functions of OSPs are also organ-specific and are sensitive and useful to assess the quality of OSPs. We hope our breadth study can open doors to explore the molecular diversity and dynamics of organ specificity at the protein level. |
format | Online Article Text |
id | pubmed-8700158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87001582021-12-24 Mouse Organ-Specific Proteins and Functions Sun, Bingyun Lorang, Cynthia Qin, Shizhen Zhang, Yijuan Liu, Ken Li, Gray Sun, Zhi Francke, Ashley Utleg, Angelita G. Hu, Zhiyuan Wang, Kai Moritz, Robert L. Hood, Leroy Cells Article Organ-specific proteins (OSPs) possess great medical potential both in clinics and in biomedical research. Applications of them—such as alanine transaminase, aspartate transaminase, and troponins—in clinics have raised certain concerns of their organ specificity. The dynamics and diversity of protein expression in heterogeneous human populations are well known, yet their effects on OSPs are less addressed. Here, we used mice as a model and implemented a breadth study to examine the panorgan proteome for potential variations in organ specificity in different genetic backgrounds. Using reasonable resources, we generated panorgan proteomes of four in-bred mouse strains. The results revealed a large diversity that was more profound among OSPs than among proteomes overall. We defined a robustness score to quantify such variation and derived three sets of OSPs with different stringencies. In the meantime, we found that the enriched biological functions of OSPs are also organ-specific and are sensitive and useful to assess the quality of OSPs. We hope our breadth study can open doors to explore the molecular diversity and dynamics of organ specificity at the protein level. MDPI 2021-12-08 /pmc/articles/PMC8700158/ /pubmed/34943957 http://dx.doi.org/10.3390/cells10123449 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sun, Bingyun Lorang, Cynthia Qin, Shizhen Zhang, Yijuan Liu, Ken Li, Gray Sun, Zhi Francke, Ashley Utleg, Angelita G. Hu, Zhiyuan Wang, Kai Moritz, Robert L. Hood, Leroy Mouse Organ-Specific Proteins and Functions |
title | Mouse Organ-Specific Proteins and Functions |
title_full | Mouse Organ-Specific Proteins and Functions |
title_fullStr | Mouse Organ-Specific Proteins and Functions |
title_full_unstemmed | Mouse Organ-Specific Proteins and Functions |
title_short | Mouse Organ-Specific Proteins and Functions |
title_sort | mouse organ-specific proteins and functions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700158/ https://www.ncbi.nlm.nih.gov/pubmed/34943957 http://dx.doi.org/10.3390/cells10123449 |
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