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Cerebral [(18)F]-FDOPA Uptake in Autism Spectrum Disorder and Its Association with Autistic Traits

Dopaminergic signaling is believed to be related to autistic traits. We conducted an exploratory 3,4-dihydroxy-6-[(18)F]-fluoro-L-phenylalanine positron emission tomography/computed tomography ([(18)F]-FDOPA PET/CT) study, to examine cerebral [(18)F]-FDOPA influx constant (k(i)(cer) min(−1)), reflec...

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Autores principales: Schalbroeck, Rik, de Geus-Oei, Lioe-Fee, Selten, Jean-Paul, Yaqub, Maqsood, Schrantee, Anouk, van Amelsvoort, Therese, Booij, Jan, van Velden, Floris H. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700159/
https://www.ncbi.nlm.nih.gov/pubmed/34943640
http://dx.doi.org/10.3390/diagnostics11122404
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author Schalbroeck, Rik
de Geus-Oei, Lioe-Fee
Selten, Jean-Paul
Yaqub, Maqsood
Schrantee, Anouk
van Amelsvoort, Therese
Booij, Jan
van Velden, Floris H. P.
author_facet Schalbroeck, Rik
de Geus-Oei, Lioe-Fee
Selten, Jean-Paul
Yaqub, Maqsood
Schrantee, Anouk
van Amelsvoort, Therese
Booij, Jan
van Velden, Floris H. P.
author_sort Schalbroeck, Rik
collection PubMed
description Dopaminergic signaling is believed to be related to autistic traits. We conducted an exploratory 3,4-dihydroxy-6-[(18)F]-fluoro-L-phenylalanine positron emission tomography/computed tomography ([(18)F]-FDOPA PET/CT) study, to examine cerebral [(18)F]-FDOPA influx constant (k(i)(cer) min(−1)), reflecting predominantly striatal dopamine synthesis capacity and a mixed monoaminergic innervation in extrastriatal neurons, in 44 adults diagnosed with autism spectrum disorder (ASD) and 22 controls, aged 18 to 30 years. Autistic traits were assessed with the Autism Spectrum Quotient (AQ). Region-of-interest and voxel-based analyses showed no statistically significant differences in k(i)(cer) between autistic adults and controls. In autistic adults, striatal k(i)(cer) was significantly, negatively associated with AQ attention to detail subscale scores, although Bayesian analyses did not support this finding. In conclusion, among autistic adults, specific autistic traits can be associated with reduced striatal dopamine synthesis capacity. However, replication of this finding is necessary.
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spelling pubmed-87001592021-12-24 Cerebral [(18)F]-FDOPA Uptake in Autism Spectrum Disorder and Its Association with Autistic Traits Schalbroeck, Rik de Geus-Oei, Lioe-Fee Selten, Jean-Paul Yaqub, Maqsood Schrantee, Anouk van Amelsvoort, Therese Booij, Jan van Velden, Floris H. P. Diagnostics (Basel) Communication Dopaminergic signaling is believed to be related to autistic traits. We conducted an exploratory 3,4-dihydroxy-6-[(18)F]-fluoro-L-phenylalanine positron emission tomography/computed tomography ([(18)F]-FDOPA PET/CT) study, to examine cerebral [(18)F]-FDOPA influx constant (k(i)(cer) min(−1)), reflecting predominantly striatal dopamine synthesis capacity and a mixed monoaminergic innervation in extrastriatal neurons, in 44 adults diagnosed with autism spectrum disorder (ASD) and 22 controls, aged 18 to 30 years. Autistic traits were assessed with the Autism Spectrum Quotient (AQ). Region-of-interest and voxel-based analyses showed no statistically significant differences in k(i)(cer) between autistic adults and controls. In autistic adults, striatal k(i)(cer) was significantly, negatively associated with AQ attention to detail subscale scores, although Bayesian analyses did not support this finding. In conclusion, among autistic adults, specific autistic traits can be associated with reduced striatal dopamine synthesis capacity. However, replication of this finding is necessary. MDPI 2021-12-20 /pmc/articles/PMC8700159/ /pubmed/34943640 http://dx.doi.org/10.3390/diagnostics11122404 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Schalbroeck, Rik
de Geus-Oei, Lioe-Fee
Selten, Jean-Paul
Yaqub, Maqsood
Schrantee, Anouk
van Amelsvoort, Therese
Booij, Jan
van Velden, Floris H. P.
Cerebral [(18)F]-FDOPA Uptake in Autism Spectrum Disorder and Its Association with Autistic Traits
title Cerebral [(18)F]-FDOPA Uptake in Autism Spectrum Disorder and Its Association with Autistic Traits
title_full Cerebral [(18)F]-FDOPA Uptake in Autism Spectrum Disorder and Its Association with Autistic Traits
title_fullStr Cerebral [(18)F]-FDOPA Uptake in Autism Spectrum Disorder and Its Association with Autistic Traits
title_full_unstemmed Cerebral [(18)F]-FDOPA Uptake in Autism Spectrum Disorder and Its Association with Autistic Traits
title_short Cerebral [(18)F]-FDOPA Uptake in Autism Spectrum Disorder and Its Association with Autistic Traits
title_sort cerebral [(18)f]-fdopa uptake in autism spectrum disorder and its association with autistic traits
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700159/
https://www.ncbi.nlm.nih.gov/pubmed/34943640
http://dx.doi.org/10.3390/diagnostics11122404
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