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Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives

CCNs are a specific type of matricellular protein, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members, which exist only in vertebrates. The architecture of CCN proteins is multi-modular comprising fou...

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Autores principales: Ahmed, Kazi Ahsan, Hasib, Tasnin Al, Paul, Shamrat Kumar, Saddam, Md., Mimi, Afsana, Saikat, Abu Saim Mohammad, Faruque, Hasan Al, Rahman, Md. Ataur, Uddin, Md. Jamal, Kim, Bonglee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700172/
https://www.ncbi.nlm.nih.gov/pubmed/34940056
http://dx.doi.org/10.3390/curroncol28060417
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author Ahmed, Kazi Ahsan
Hasib, Tasnin Al
Paul, Shamrat Kumar
Saddam, Md.
Mimi, Afsana
Saikat, Abu Saim Mohammad
Faruque, Hasan Al
Rahman, Md. Ataur
Uddin, Md. Jamal
Kim, Bonglee
author_facet Ahmed, Kazi Ahsan
Hasib, Tasnin Al
Paul, Shamrat Kumar
Saddam, Md.
Mimi, Afsana
Saikat, Abu Saim Mohammad
Faruque, Hasan Al
Rahman, Md. Ataur
Uddin, Md. Jamal
Kim, Bonglee
author_sort Ahmed, Kazi Ahsan
collection PubMed
description CCNs are a specific type of matricellular protein, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members, which exist only in vertebrates. The architecture of CCN proteins is multi-modular comprising four distinct modules. CCN Proteins achieve their primary functional activities by binding with several integrin7 receptors. The CCN family has been linked to cell adhesion, chemotaxis and migration, mitogenesis, cell survival, angiogenesis, differentiation, tumorigenesis, chondrogenesis, and wound healing, among other biological interactions. Breast cancer is the most commonly diagnosed cancer worldwide and CCN regulated breast cancer stands at the top. A favorable or unfavorable association between various CCNs has been reported in patients with breast carcinomas. The pro-tumorigenic CCN1, CCN2, CCN3, and CCN4 may lead to human breast cancer, although the anti-tumorigenic actions of CCN5 and CCN6 are also present. Several studies have been conducted on CCN proteins and cancer in recent years. CCN1 and CCN3 have been shown to exhibit a dual nature of tumor inhibition and tumor suppression to some extent in quiet recent time. Pharmacological advances in treating breast cancer by targeting CCN proteins are also reported. In our study, we intend to provide an overview of these research works while keeping breast cancer in focus. This information may facilitate early diagnosis, early prognosis and the development of new therapeutic strategies.
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spelling pubmed-87001722021-12-24 Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives Ahmed, Kazi Ahsan Hasib, Tasnin Al Paul, Shamrat Kumar Saddam, Md. Mimi, Afsana Saikat, Abu Saim Mohammad Faruque, Hasan Al Rahman, Md. Ataur Uddin, Md. Jamal Kim, Bonglee Curr Oncol Review CCNs are a specific type of matricellular protein, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members, which exist only in vertebrates. The architecture of CCN proteins is multi-modular comprising four distinct modules. CCN Proteins achieve their primary functional activities by binding with several integrin7 receptors. The CCN family has been linked to cell adhesion, chemotaxis and migration, mitogenesis, cell survival, angiogenesis, differentiation, tumorigenesis, chondrogenesis, and wound healing, among other biological interactions. Breast cancer is the most commonly diagnosed cancer worldwide and CCN regulated breast cancer stands at the top. A favorable or unfavorable association between various CCNs has been reported in patients with breast carcinomas. The pro-tumorigenic CCN1, CCN2, CCN3, and CCN4 may lead to human breast cancer, although the anti-tumorigenic actions of CCN5 and CCN6 are also present. Several studies have been conducted on CCN proteins and cancer in recent years. CCN1 and CCN3 have been shown to exhibit a dual nature of tumor inhibition and tumor suppression to some extent in quiet recent time. Pharmacological advances in treating breast cancer by targeting CCN proteins are also reported. In our study, we intend to provide an overview of these research works while keeping breast cancer in focus. This information may facilitate early diagnosis, early prognosis and the development of new therapeutic strategies. MDPI 2021-11-26 /pmc/articles/PMC8700172/ /pubmed/34940056 http://dx.doi.org/10.3390/curroncol28060417 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ahmed, Kazi Ahsan
Hasib, Tasnin Al
Paul, Shamrat Kumar
Saddam, Md.
Mimi, Afsana
Saikat, Abu Saim Mohammad
Faruque, Hasan Al
Rahman, Md. Ataur
Uddin, Md. Jamal
Kim, Bonglee
Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives
title Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives
title_full Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives
title_fullStr Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives
title_full_unstemmed Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives
title_short Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives
title_sort potential role of ccn proteins in breast cancer: therapeutic advances and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700172/
https://www.ncbi.nlm.nih.gov/pubmed/34940056
http://dx.doi.org/10.3390/curroncol28060417
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