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Defucosylated Mouse–Dog Chimeric Anti-EGFR Antibody Exerts Antitumor Activities in Mouse Xenograft Models of Canine Tumors

The epidermal growth factor receptor (EGFR) contributes to tumor malignancy via gene amplification and protein overexpression. Previously, we developed an anti-human EGFR (hEGFR) monoclonal antibody, namely EMab-134, which detects hEGFR and dog EGFR (dEGFR) with high sensitivity and specificity. In...

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Detalles Bibliográficos
Autores principales:	Li, Guanjie, Ohishi, Tomokazu, Kaneko, Mika K., Takei, Junko, Mizuno, Takuya, Kawada, Manabu, Saito, Masaki, Suzuki, Hiroyuki, Kato, Yukinari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700185/ https://www.ncbi.nlm.nih.gov/pubmed/34944112 http://dx.doi.org/10.3390/cells10123599

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