Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface

G protein-coupled receptors (GPCRs) are among the most promising drug targets. They often form homo- and heterodimers with allosteric cross-talk between receptor entities, which contributes to fine-tuning of transmembrane signaling. Specifically controlling the activity of GPCR dimers with ligands i...

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Detalles Bibliográficos
Autores principales: Liu, Lei, Fan, Zhiran, Rovira, Xavier, Xue, Li, Roux, Salomé, Brabet, Isabelle, Xin, Mingxia, Pin, Jean-Philippe, Rondard, Philippe, Liu, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700296/
https://www.ncbi.nlm.nih.gov/pubmed/34866572
http://dx.doi.org/10.7554/eLife.70188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700296/
https://www.ncbi.nlm.nih.gov/pubmed/34866572
http://dx.doi.org/10.7554/eLife.70188

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