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The Current Status of Neuroprotection in Congenital Heart Disease
Neurological deficits are a serious and common sequelae of congenital heart disease (CHD). While their underlying mechanisms have not been fully characterized, their manifestations are well-known and understood to persist through adulthood. Development of therapies to address or prevent these defici...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700367/ https://www.ncbi.nlm.nih.gov/pubmed/34943311 http://dx.doi.org/10.3390/children8121116 |
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author | Kobayashi, Kei Liu, Christopher Jonas, Richard A. Ishibashi, Nobuyuki |
author_facet | Kobayashi, Kei Liu, Christopher Jonas, Richard A. Ishibashi, Nobuyuki |
author_sort | Kobayashi, Kei |
collection | PubMed |
description | Neurological deficits are a serious and common sequelae of congenital heart disease (CHD). While their underlying mechanisms have not been fully characterized, their manifestations are well-known and understood to persist through adulthood. Development of therapies to address or prevent these deficits are critical to attenuate future morbidity and improve quality of life. In this review, we aim to summarize the current status of neuroprotective therapy in CHD. Through an exploration of present research in the pre-operative, intra-operative, and post-operative phases of patient management, we will describe existing clinical and bench efforts as well as current endeavors underway within this research area. |
format | Online Article Text |
id | pubmed-8700367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87003672021-12-24 The Current Status of Neuroprotection in Congenital Heart Disease Kobayashi, Kei Liu, Christopher Jonas, Richard A. Ishibashi, Nobuyuki Children (Basel) Review Neurological deficits are a serious and common sequelae of congenital heart disease (CHD). While their underlying mechanisms have not been fully characterized, their manifestations are well-known and understood to persist through adulthood. Development of therapies to address or prevent these deficits are critical to attenuate future morbidity and improve quality of life. In this review, we aim to summarize the current status of neuroprotective therapy in CHD. Through an exploration of present research in the pre-operative, intra-operative, and post-operative phases of patient management, we will describe existing clinical and bench efforts as well as current endeavors underway within this research area. MDPI 2021-12-02 /pmc/articles/PMC8700367/ /pubmed/34943311 http://dx.doi.org/10.3390/children8121116 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kobayashi, Kei Liu, Christopher Jonas, Richard A. Ishibashi, Nobuyuki The Current Status of Neuroprotection in Congenital Heart Disease |
title | The Current Status of Neuroprotection in Congenital Heart Disease |
title_full | The Current Status of Neuroprotection in Congenital Heart Disease |
title_fullStr | The Current Status of Neuroprotection in Congenital Heart Disease |
title_full_unstemmed | The Current Status of Neuroprotection in Congenital Heart Disease |
title_short | The Current Status of Neuroprotection in Congenital Heart Disease |
title_sort | current status of neuroprotection in congenital heart disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700367/ https://www.ncbi.nlm.nih.gov/pubmed/34943311 http://dx.doi.org/10.3390/children8121116 |
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