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The Current Status of Neuroprotection in Congenital Heart Disease

Neurological deficits are a serious and common sequelae of congenital heart disease (CHD). While their underlying mechanisms have not been fully characterized, their manifestations are well-known and understood to persist through adulthood. Development of therapies to address or prevent these defici...

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Autores principales: Kobayashi, Kei, Liu, Christopher, Jonas, Richard A., Ishibashi, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700367/
https://www.ncbi.nlm.nih.gov/pubmed/34943311
http://dx.doi.org/10.3390/children8121116
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author Kobayashi, Kei
Liu, Christopher
Jonas, Richard A.
Ishibashi, Nobuyuki
author_facet Kobayashi, Kei
Liu, Christopher
Jonas, Richard A.
Ishibashi, Nobuyuki
author_sort Kobayashi, Kei
collection PubMed
description Neurological deficits are a serious and common sequelae of congenital heart disease (CHD). While their underlying mechanisms have not been fully characterized, their manifestations are well-known and understood to persist through adulthood. Development of therapies to address or prevent these deficits are critical to attenuate future morbidity and improve quality of life. In this review, we aim to summarize the current status of neuroprotective therapy in CHD. Through an exploration of present research in the pre-operative, intra-operative, and post-operative phases of patient management, we will describe existing clinical and bench efforts as well as current endeavors underway within this research area.
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spelling pubmed-87003672021-12-24 The Current Status of Neuroprotection in Congenital Heart Disease Kobayashi, Kei Liu, Christopher Jonas, Richard A. Ishibashi, Nobuyuki Children (Basel) Review Neurological deficits are a serious and common sequelae of congenital heart disease (CHD). While their underlying mechanisms have not been fully characterized, their manifestations are well-known and understood to persist through adulthood. Development of therapies to address or prevent these deficits are critical to attenuate future morbidity and improve quality of life. In this review, we aim to summarize the current status of neuroprotective therapy in CHD. Through an exploration of present research in the pre-operative, intra-operative, and post-operative phases of patient management, we will describe existing clinical and bench efforts as well as current endeavors underway within this research area. MDPI 2021-12-02 /pmc/articles/PMC8700367/ /pubmed/34943311 http://dx.doi.org/10.3390/children8121116 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kobayashi, Kei
Liu, Christopher
Jonas, Richard A.
Ishibashi, Nobuyuki
The Current Status of Neuroprotection in Congenital Heart Disease
title The Current Status of Neuroprotection in Congenital Heart Disease
title_full The Current Status of Neuroprotection in Congenital Heart Disease
title_fullStr The Current Status of Neuroprotection in Congenital Heart Disease
title_full_unstemmed The Current Status of Neuroprotection in Congenital Heart Disease
title_short The Current Status of Neuroprotection in Congenital Heart Disease
title_sort current status of neuroprotection in congenital heart disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700367/
https://www.ncbi.nlm.nih.gov/pubmed/34943311
http://dx.doi.org/10.3390/children8121116
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