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Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a malignant tumor of the mesothelial lining of the thorax. It has been related to frequent exposure to asbestos. Diagnosis of malignant pleural mesothelioma is considered a criticizing problem for clinicians. Early diagnosis and sufficient surgical excision of...

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Autores principales: Gharib, Amal F., Alaa Eldeen, Muhammad, Khalifa, Amany Salah, Elsawy, Wael H., Eed, Emad Mohamed, Askary, Ahmad El, Eid, Refaat A., Soltan, Mohamed A., Raafat, Nermin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700378/
https://www.ncbi.nlm.nih.gov/pubmed/34943522
http://dx.doi.org/10.3390/diagnostics11122285
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author Gharib, Amal F.
Alaa Eldeen, Muhammad
Khalifa, Amany Salah
Elsawy, Wael H.
Eed, Emad Mohamed
Askary, Ahmad El
Eid, Refaat A.
Soltan, Mohamed A.
Raafat, Nermin
author_facet Gharib, Amal F.
Alaa Eldeen, Muhammad
Khalifa, Amany Salah
Elsawy, Wael H.
Eed, Emad Mohamed
Askary, Ahmad El
Eid, Refaat A.
Soltan, Mohamed A.
Raafat, Nermin
author_sort Gharib, Amal F.
collection PubMed
description Malignant pleural mesothelioma (MPM) is a malignant tumor of the mesothelial lining of the thorax. It has been related to frequent exposure to asbestos. Diagnosis of malignant pleural mesothelioma is considered a criticizing problem for clinicians. Early diagnosis and sufficient surgical excision of MPM are considered the cornerstone success factors for the management of early MPM. Glutathione peroxidase-1 (GPX1) is an intracellular protein found to be extensively distributed in all cells, and it belongs to the GPX group. In the current study, we included ninety-eight patients with MPM that underwent surgery at the Zagazig University Hospital in Egypt. We assessed GPX1 gene expression level as it was thought to be related to pathogenicity of cancer in a variety of malignant tumors. We observed a significant elevation in GPX1-mRNA levels in MPM relative to the nearby normal pleural tissues. It was found to be of important diagnostic specificity in the differentiation of MPM from normal tissues. Moreover, we studied the survival of patients in correlation to the GPX1 expression levels and we reported that median overall survival was about 16 months in patients with high GPX1 expression levels, while it was found to be about 40 months in low GPX1 levels.
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spelling pubmed-87003782021-12-24 Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma Gharib, Amal F. Alaa Eldeen, Muhammad Khalifa, Amany Salah Elsawy, Wael H. Eed, Emad Mohamed Askary, Ahmad El Eid, Refaat A. Soltan, Mohamed A. Raafat, Nermin Diagnostics (Basel) Article Malignant pleural mesothelioma (MPM) is a malignant tumor of the mesothelial lining of the thorax. It has been related to frequent exposure to asbestos. Diagnosis of malignant pleural mesothelioma is considered a criticizing problem for clinicians. Early diagnosis and sufficient surgical excision of MPM are considered the cornerstone success factors for the management of early MPM. Glutathione peroxidase-1 (GPX1) is an intracellular protein found to be extensively distributed in all cells, and it belongs to the GPX group. In the current study, we included ninety-eight patients with MPM that underwent surgery at the Zagazig University Hospital in Egypt. We assessed GPX1 gene expression level as it was thought to be related to pathogenicity of cancer in a variety of malignant tumors. We observed a significant elevation in GPX1-mRNA levels in MPM relative to the nearby normal pleural tissues. It was found to be of important diagnostic specificity in the differentiation of MPM from normal tissues. Moreover, we studied the survival of patients in correlation to the GPX1 expression levels and we reported that median overall survival was about 16 months in patients with high GPX1 expression levels, while it was found to be about 40 months in low GPX1 levels. MDPI 2021-12-07 /pmc/articles/PMC8700378/ /pubmed/34943522 http://dx.doi.org/10.3390/diagnostics11122285 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gharib, Amal F.
Alaa Eldeen, Muhammad
Khalifa, Amany Salah
Elsawy, Wael H.
Eed, Emad Mohamed
Askary, Ahmad El
Eid, Refaat A.
Soltan, Mohamed A.
Raafat, Nermin
Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma
title Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma
title_full Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma
title_fullStr Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma
title_full_unstemmed Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma
title_short Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma
title_sort assessment of glutathione peroxidase-1 (gpx1) gene expression as a specific diagnostic and prognostic biomarker in malignant pleural mesothelioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700378/
https://www.ncbi.nlm.nih.gov/pubmed/34943522
http://dx.doi.org/10.3390/diagnostics11122285
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