INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View

Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In...

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Autores principales: Maleki, Zahra, Nadella, Akash, Nadella, Mohnish, Patel, Gopi, Patel, Shivni, Kholová, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700458/
https://www.ncbi.nlm.nih.gov/pubmed/34943408
http://dx.doi.org/10.3390/diagnostics11122172
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author Maleki, Zahra
Nadella, Akash
Nadella, Mohnish
Patel, Gopi
Patel, Shivni
Kholová, Ivana
author_facet Maleki, Zahra
Nadella, Akash
Nadella, Mohnish
Patel, Gopi
Patel, Shivni
Kholová, Ivana
author_sort Maleki, Zahra
collection PubMed
description Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In this review, we summarize existing literature on INSM1′s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears).
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spelling pubmed-87004582021-12-24 INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View Maleki, Zahra Nadella, Akash Nadella, Mohnish Patel, Gopi Patel, Shivni Kholová, Ivana Diagnostics (Basel) Review Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In this review, we summarize existing literature on INSM1′s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears). MDPI 2021-11-23 /pmc/articles/PMC8700458/ /pubmed/34943408 http://dx.doi.org/10.3390/diagnostics11122172 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maleki, Zahra
Nadella, Akash
Nadella, Mohnish
Patel, Gopi
Patel, Shivni
Kholová, Ivana
INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View
title INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View
title_full INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View
title_fullStr INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View
title_full_unstemmed INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View
title_short INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View
title_sort insm1, a novel biomarker for detection of neuroendocrine neoplasms: cytopathologists’ view
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700458/
https://www.ncbi.nlm.nih.gov/pubmed/34943408
http://dx.doi.org/10.3390/diagnostics11122172
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