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Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review
Modern advances in molecular medicine have led to the reframing of osteoarthritis as a metabolically active, inflammatory disorder with local and systemic contributing factors. According to the ‘inflammatory theory’ of osteoarthritis, immune response to an initial damage is the key trigger that lead...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700461/ https://www.ncbi.nlm.nih.gov/pubmed/34940003 http://dx.doi.org/10.3390/clinpract11040104 |
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author | Eriksen, Erik Fink Lech, Osvandre Nakama, Gilberto Yoshinobu O’Gorman, Denise M. |
author_facet | Eriksen, Erik Fink Lech, Osvandre Nakama, Gilberto Yoshinobu O’Gorman, Denise M. |
author_sort | Eriksen, Erik Fink |
collection | PubMed |
description | Modern advances in molecular medicine have led to the reframing of osteoarthritis as a metabolically active, inflammatory disorder with local and systemic contributing factors. According to the ‘inflammatory theory’ of osteoarthritis, immune response to an initial damage is the key trigger that leads to progressive joint destruction. Several intertwined pathways are known to induce and govern articular inflammation, cartilage matrix degradation, and subchondral bone changes. Effective treatments capable of halting or delaying the progression of osteoarthritis remain elusive. As a result, supplements such as glucosamine and chondroitin sulphate are commonly used despite the lack of scientific consensus. A novel option for adjunctive therapy of osteoarthritis is LithoLexal(®) Joint, a marine-derived, mineral-rich extract, that exhibited significant efficacy in clinical trials. LithoLexal(®) has a lattice microstructure containing a combination of bioactive rare minerals. Mechanistic research suggests that this novel treatment possesses various potential disease-modifying properties, such as suppression of nuclear factor kappa-B, interleukin 1β, tumor necrosis factor α, and cyclooxygenase-2. Accordingly, LithoLexal(®) Joint can be considered a disease-modifying adjunctive therapy (DMAT). LithoLexal(®) Joint monotherapy in patients with knee osteoarthritis has significantly improved symptoms and walking ability with higher efficacy than glucosamine. Preliminary evidence also suggests that LithoLexal(®) Joint may allow clinicians to reduce the dose of nonsteroidal anti-inflammatory drugs in osteoarthritic patients by up to 50%. In conclusion, the multi-mineral complex, LithoLexal(®) Joint, appears to be a promising candidate for DMAT of osteoarthritis, which may narrow the existing gap in clinical practice. |
format | Online Article Text |
id | pubmed-8700461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87004612021-12-24 Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review Eriksen, Erik Fink Lech, Osvandre Nakama, Gilberto Yoshinobu O’Gorman, Denise M. Clin Pract Review Modern advances in molecular medicine have led to the reframing of osteoarthritis as a metabolically active, inflammatory disorder with local and systemic contributing factors. According to the ‘inflammatory theory’ of osteoarthritis, immune response to an initial damage is the key trigger that leads to progressive joint destruction. Several intertwined pathways are known to induce and govern articular inflammation, cartilage matrix degradation, and subchondral bone changes. Effective treatments capable of halting or delaying the progression of osteoarthritis remain elusive. As a result, supplements such as glucosamine and chondroitin sulphate are commonly used despite the lack of scientific consensus. A novel option for adjunctive therapy of osteoarthritis is LithoLexal(®) Joint, a marine-derived, mineral-rich extract, that exhibited significant efficacy in clinical trials. LithoLexal(®) has a lattice microstructure containing a combination of bioactive rare minerals. Mechanistic research suggests that this novel treatment possesses various potential disease-modifying properties, such as suppression of nuclear factor kappa-B, interleukin 1β, tumor necrosis factor α, and cyclooxygenase-2. Accordingly, LithoLexal(®) Joint can be considered a disease-modifying adjunctive therapy (DMAT). LithoLexal(®) Joint monotherapy in patients with knee osteoarthritis has significantly improved symptoms and walking ability with higher efficacy than glucosamine. Preliminary evidence also suggests that LithoLexal(®) Joint may allow clinicians to reduce the dose of nonsteroidal anti-inflammatory drugs in osteoarthritic patients by up to 50%. In conclusion, the multi-mineral complex, LithoLexal(®) Joint, appears to be a promising candidate for DMAT of osteoarthritis, which may narrow the existing gap in clinical practice. MDPI 2021-11-26 /pmc/articles/PMC8700461/ /pubmed/34940003 http://dx.doi.org/10.3390/clinpract11040104 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Eriksen, Erik Fink Lech, Osvandre Nakama, Gilberto Yoshinobu O’Gorman, Denise M. Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review |
title | Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review |
title_full | Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review |
title_fullStr | Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review |
title_full_unstemmed | Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review |
title_short | Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review |
title_sort | disease-modifying adjunctive therapy (dmat) in osteoarthritis—the biological effects of a multi-mineral complex, litholexal(®) joint—a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700461/ https://www.ncbi.nlm.nih.gov/pubmed/34940003 http://dx.doi.org/10.3390/clinpract11040104 |
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