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Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review

Modern advances in molecular medicine have led to the reframing of osteoarthritis as a metabolically active, inflammatory disorder with local and systemic contributing factors. According to the ‘inflammatory theory’ of osteoarthritis, immune response to an initial damage is the key trigger that lead...

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Autores principales: Eriksen, Erik Fink, Lech, Osvandre, Nakama, Gilberto Yoshinobu, O’Gorman, Denise M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700461/
https://www.ncbi.nlm.nih.gov/pubmed/34940003
http://dx.doi.org/10.3390/clinpract11040104
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author Eriksen, Erik Fink
Lech, Osvandre
Nakama, Gilberto Yoshinobu
O’Gorman, Denise M.
author_facet Eriksen, Erik Fink
Lech, Osvandre
Nakama, Gilberto Yoshinobu
O’Gorman, Denise M.
author_sort Eriksen, Erik Fink
collection PubMed
description Modern advances in molecular medicine have led to the reframing of osteoarthritis as a metabolically active, inflammatory disorder with local and systemic contributing factors. According to the ‘inflammatory theory’ of osteoarthritis, immune response to an initial damage is the key trigger that leads to progressive joint destruction. Several intertwined pathways are known to induce and govern articular inflammation, cartilage matrix degradation, and subchondral bone changes. Effective treatments capable of halting or delaying the progression of osteoarthritis remain elusive. As a result, supplements such as glucosamine and chondroitin sulphate are commonly used despite the lack of scientific consensus. A novel option for adjunctive therapy of osteoarthritis is LithoLexal(®) Joint, a marine-derived, mineral-rich extract, that exhibited significant efficacy in clinical trials. LithoLexal(®) has a lattice microstructure containing a combination of bioactive rare minerals. Mechanistic research suggests that this novel treatment possesses various potential disease-modifying properties, such as suppression of nuclear factor kappa-B, interleukin 1β, tumor necrosis factor α, and cyclooxygenase-2. Accordingly, LithoLexal(®) Joint can be considered a disease-modifying adjunctive therapy (DMAT). LithoLexal(®) Joint monotherapy in patients with knee osteoarthritis has significantly improved symptoms and walking ability with higher efficacy than glucosamine. Preliminary evidence also suggests that LithoLexal(®) Joint may allow clinicians to reduce the dose of nonsteroidal anti-inflammatory drugs in osteoarthritic patients by up to 50%. In conclusion, the multi-mineral complex, LithoLexal(®) Joint, appears to be a promising candidate for DMAT of osteoarthritis, which may narrow the existing gap in clinical practice.
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spelling pubmed-87004612021-12-24 Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review Eriksen, Erik Fink Lech, Osvandre Nakama, Gilberto Yoshinobu O’Gorman, Denise M. Clin Pract Review Modern advances in molecular medicine have led to the reframing of osteoarthritis as a metabolically active, inflammatory disorder with local and systemic contributing factors. According to the ‘inflammatory theory’ of osteoarthritis, immune response to an initial damage is the key trigger that leads to progressive joint destruction. Several intertwined pathways are known to induce and govern articular inflammation, cartilage matrix degradation, and subchondral bone changes. Effective treatments capable of halting or delaying the progression of osteoarthritis remain elusive. As a result, supplements such as glucosamine and chondroitin sulphate are commonly used despite the lack of scientific consensus. A novel option for adjunctive therapy of osteoarthritis is LithoLexal(®) Joint, a marine-derived, mineral-rich extract, that exhibited significant efficacy in clinical trials. LithoLexal(®) has a lattice microstructure containing a combination of bioactive rare minerals. Mechanistic research suggests that this novel treatment possesses various potential disease-modifying properties, such as suppression of nuclear factor kappa-B, interleukin 1β, tumor necrosis factor α, and cyclooxygenase-2. Accordingly, LithoLexal(®) Joint can be considered a disease-modifying adjunctive therapy (DMAT). LithoLexal(®) Joint monotherapy in patients with knee osteoarthritis has significantly improved symptoms and walking ability with higher efficacy than glucosamine. Preliminary evidence also suggests that LithoLexal(®) Joint may allow clinicians to reduce the dose of nonsteroidal anti-inflammatory drugs in osteoarthritic patients by up to 50%. In conclusion, the multi-mineral complex, LithoLexal(®) Joint, appears to be a promising candidate for DMAT of osteoarthritis, which may narrow the existing gap in clinical practice. MDPI 2021-11-26 /pmc/articles/PMC8700461/ /pubmed/34940003 http://dx.doi.org/10.3390/clinpract11040104 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Eriksen, Erik Fink
Lech, Osvandre
Nakama, Gilberto Yoshinobu
O’Gorman, Denise M.
Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review
title Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review
title_full Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review
title_fullStr Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review
title_full_unstemmed Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review
title_short Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal(®) Joint—A Review
title_sort disease-modifying adjunctive therapy (dmat) in osteoarthritis—the biological effects of a multi-mineral complex, litholexal(®) joint—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700461/
https://www.ncbi.nlm.nih.gov/pubmed/34940003
http://dx.doi.org/10.3390/clinpract11040104
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