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A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland
The salivary gland (SG) microvasculature constitutes a dynamic cellular organization instrumental to preserving tissue stability and homeostasis. The interplay between pericytes (PCs) and endothelial cells (ECs) culminates as a key ingredient that coordinates the development, maturation, and integri...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700478/ https://www.ncbi.nlm.nih.gov/pubmed/34940041 http://dx.doi.org/10.3390/dj9120144 |
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author | Cucu, Ioana Nicolescu, Mihnea Ioan |
author_facet | Cucu, Ioana Nicolescu, Mihnea Ioan |
author_sort | Cucu, Ioana |
collection | PubMed |
description | The salivary gland (SG) microvasculature constitutes a dynamic cellular organization instrumental to preserving tissue stability and homeostasis. The interplay between pericytes (PCs) and endothelial cells (ECs) culminates as a key ingredient that coordinates the development, maturation, and integrity of vessel building blocks. PCs, as a variety of mesenchymal stem cells, enthrall in the field of regenerative medicine, supporting the notion of regeneration and repair. PC-EC interconnections are pivotal in the kinetic and intricate process of angiogenesis during both embryological and post-natal development. The disruption of this complex interlinkage corresponds to SG pathogenesis, including inflammation, autoimmune disorders (Sjögren’s syndrome), and tumorigenesis. Here, we provided a global portrayal of major signaling pathways between PCs and ECs that cooperate to enhance vascular steadiness through the synergistic interchange. Additionally, we delineated how the crosstalk among molecular networks affiliate to contribute to a malignant context. Additionally, within SG microarchitecture, telocytes and myoepithelial cells assemble a labyrinthine companionship, which together with PCs appear to synchronize the regenerative potential of parenchymal constituents. By underscoring the intricacy of signaling cascades within cellular latticework, this review sketched a perceptive basis for target-selective drugs to safeguard SG function. |
format | Online Article Text |
id | pubmed-8700478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87004782021-12-24 A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland Cucu, Ioana Nicolescu, Mihnea Ioan Dent J (Basel) Review The salivary gland (SG) microvasculature constitutes a dynamic cellular organization instrumental to preserving tissue stability and homeostasis. The interplay between pericytes (PCs) and endothelial cells (ECs) culminates as a key ingredient that coordinates the development, maturation, and integrity of vessel building blocks. PCs, as a variety of mesenchymal stem cells, enthrall in the field of regenerative medicine, supporting the notion of regeneration and repair. PC-EC interconnections are pivotal in the kinetic and intricate process of angiogenesis during both embryological and post-natal development. The disruption of this complex interlinkage corresponds to SG pathogenesis, including inflammation, autoimmune disorders (Sjögren’s syndrome), and tumorigenesis. Here, we provided a global portrayal of major signaling pathways between PCs and ECs that cooperate to enhance vascular steadiness through the synergistic interchange. Additionally, we delineated how the crosstalk among molecular networks affiliate to contribute to a malignant context. Additionally, within SG microarchitecture, telocytes and myoepithelial cells assemble a labyrinthine companionship, which together with PCs appear to synchronize the regenerative potential of parenchymal constituents. By underscoring the intricacy of signaling cascades within cellular latticework, this review sketched a perceptive basis for target-selective drugs to safeguard SG function. MDPI 2021-12-01 /pmc/articles/PMC8700478/ /pubmed/34940041 http://dx.doi.org/10.3390/dj9120144 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cucu, Ioana Nicolescu, Mihnea Ioan A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland |
title | A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland |
title_full | A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland |
title_fullStr | A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland |
title_full_unstemmed | A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland |
title_short | A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland |
title_sort | synopsis of signaling crosstalk of pericytes and endothelial cells in salivary gland |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700478/ https://www.ncbi.nlm.nih.gov/pubmed/34940041 http://dx.doi.org/10.3390/dj9120144 |
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