Giardia duodenalis and Its Secreted PPIB Trigger Inflammasome Activation and Pyroptosis in Macrophages through TLR4-Induced ROS Signaling and A20-Mediated NLRP3 Deubiquitination

The extracellular protozoan parasite Giardia duodenalis is a well-known and important causative agent of diarrhea on a global scale. Macrophage pyroptosis has been recognized as an important innate immune effector mechanism against intracellular pathogens. Yet, the effects of noninvasive Giardia inf...

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Detalles Bibliográficos
Autores principales: Liu, Lin, Yang, Yongwu, Fang, Rui, Zhu, Weining, Wu, Jingxue, Li, Xiaoyun, Patankar, Jay V., Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700504/
https://www.ncbi.nlm.nih.gov/pubmed/34943932
http://dx.doi.org/10.3390/cells10123425

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