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Differential Dose- and Tissue-Dependent Effects of foxo on Aging, Metabolic and Proteostatic Pathways

Aging is the gradual deterioration of physiological functions that culminates in death. Several studies across a wide range of model organisms have revealed the involvement of FOXO (forkhead box, class O) transcription factors in orchestrating metabolic homeostasis, as well as in regulating longevit...

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Detalles Bibliográficos
Autores principales: Manola, Maria S., Gumeni, Sentiljana, Trougakos, Ioannis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700554/
https://www.ncbi.nlm.nih.gov/pubmed/34944088
http://dx.doi.org/10.3390/cells10123577