Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease

Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and...

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Autores principales: Nasri, Amel, Foisset, Florent, Ahmed, Engi, Lahmar, Zakaria, Vachier, Isabelle, Jorgensen, Christian, Assou, Said, Bourdin, Arnaud, De Vos, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700565/
https://www.ncbi.nlm.nih.gov/pubmed/34943975
http://dx.doi.org/10.3390/cells10123467
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author Nasri, Amel
Foisset, Florent
Ahmed, Engi
Lahmar, Zakaria
Vachier, Isabelle
Jorgensen, Christian
Assou, Said
Bourdin, Arnaud
De Vos, John
author_facet Nasri, Amel
Foisset, Florent
Ahmed, Engi
Lahmar, Zakaria
Vachier, Isabelle
Jorgensen, Christian
Assou, Said
Bourdin, Arnaud
De Vos, John
author_sort Nasri, Amel
collection PubMed
description Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease. In this review, we discuss the origins of mesenchymal cells during lung development, their crosstalk with the epithelium, and their role in lung diseases, particularly in chronic obstructive pulmonary disease.
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spelling pubmed-87005652021-12-24 Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease Nasri, Amel Foisset, Florent Ahmed, Engi Lahmar, Zakaria Vachier, Isabelle Jorgensen, Christian Assou, Said Bourdin, Arnaud De Vos, John Cells Review Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease. In this review, we discuss the origins of mesenchymal cells during lung development, their crosstalk with the epithelium, and their role in lung diseases, particularly in chronic obstructive pulmonary disease. MDPI 2021-12-09 /pmc/articles/PMC8700565/ /pubmed/34943975 http://dx.doi.org/10.3390/cells10123467 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nasri, Amel
Foisset, Florent
Ahmed, Engi
Lahmar, Zakaria
Vachier, Isabelle
Jorgensen, Christian
Assou, Said
Bourdin, Arnaud
De Vos, John
Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease
title Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease
title_full Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease
title_fullStr Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease
title_full_unstemmed Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease
title_short Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease
title_sort roles of mesenchymal cells in the lung: from lung development to chronic obstructive pulmonary disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700565/
https://www.ncbi.nlm.nih.gov/pubmed/34943975
http://dx.doi.org/10.3390/cells10123467
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