Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis

The respiratory epithelium represents the first chemical, immune, and physical barrier against inhaled noxious materials, particularly pathogens in cystic fibrosis. Local mucus thickening, altered mucociliary clearance, and reduced pH due to CFTR protein dysfunction favor bacterial overgrowth and ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Gohy, Sophie, Moeremans, Alexandra, Pilette, Charles, Collin, Amandine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700636/
https://www.ncbi.nlm.nih.gov/pubmed/34944110
http://dx.doi.org/10.3390/cells10123603
_version_ 1784620804934205440
author Gohy, Sophie
Moeremans, Alexandra
Pilette, Charles
Collin, Amandine
author_facet Gohy, Sophie
Moeremans, Alexandra
Pilette, Charles
Collin, Amandine
author_sort Gohy, Sophie
collection PubMed
description The respiratory epithelium represents the first chemical, immune, and physical barrier against inhaled noxious materials, particularly pathogens in cystic fibrosis. Local mucus thickening, altered mucociliary clearance, and reduced pH due to CFTR protein dysfunction favor bacterial overgrowth and excessive inflammation. We aimed in this review to summarize respiratory mucosal alterations within the epithelium and current knowledge on local immunity linked to immunoglobulin A in patients with cystic fibrosis.
format Online
Article
Text
id pubmed-8700636
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87006362021-12-24 Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis Gohy, Sophie Moeremans, Alexandra Pilette, Charles Collin, Amandine Cells Review The respiratory epithelium represents the first chemical, immune, and physical barrier against inhaled noxious materials, particularly pathogens in cystic fibrosis. Local mucus thickening, altered mucociliary clearance, and reduced pH due to CFTR protein dysfunction favor bacterial overgrowth and excessive inflammation. We aimed in this review to summarize respiratory mucosal alterations within the epithelium and current knowledge on local immunity linked to immunoglobulin A in patients with cystic fibrosis. MDPI 2021-12-20 /pmc/articles/PMC8700636/ /pubmed/34944110 http://dx.doi.org/10.3390/cells10123603 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gohy, Sophie
Moeremans, Alexandra
Pilette, Charles
Collin, Amandine
Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis
title Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis
title_full Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis
title_fullStr Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis
title_full_unstemmed Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis
title_short Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis
title_sort immunoglobulin a mucosal immunity and altered respiratory epithelium in cystic fibrosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700636/
https://www.ncbi.nlm.nih.gov/pubmed/34944110
http://dx.doi.org/10.3390/cells10123603
work_keys_str_mv AT gohysophie immunoglobulinamucosalimmunityandalteredrespiratoryepitheliumincysticfibrosis
AT moeremansalexandra immunoglobulinamucosalimmunityandalteredrespiratoryepitheliumincysticfibrosis
AT pilettecharles immunoglobulinamucosalimmunityandalteredrespiratoryepitheliumincysticfibrosis
AT collinamandine immunoglobulinamucosalimmunityandalteredrespiratoryepitheliumincysticfibrosis

Ejemplares similares