Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress

The maintenance of pancreatic islet architecture is crucial for proper β-cell function. We previously reported that disruption of human islet integrity could result in altered β-cell identity. Here we combine β-cell lineage tracing and single-cell transcriptomics to investigate the mechanisms underl...

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Detalles Bibliográficos
Autores principales: Groen, Nathalie, Leenders, Floris, Mahfouz, Ahmed, Munoz-Garcia, Amadeo, Muraro, Mauro J., de Graaf, Natascha, Rabelink, Ton. J., Hoeben, Rob, van Oudenaarden, Alexander, Zaldumbide, Arnaud, Reinders, Marcel J. T., de Koning, Eelco J. P., Carlotti, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700697/
https://www.ncbi.nlm.nih.gov/pubmed/34944092
http://dx.doi.org/10.3390/cells10123585

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