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Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases

Background: A Pressure Ulcer (PU) is a severe event and could create discomfort to newborns. In newborns, one of mostly stricken location by PU is occipital area. Recent studies have highlighted that Cord Blood Platelet Gel (CBPG) might be a better alternative compared to traditional treatment. We r...

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Autores principales: Ferrario, Silvia, Zorz, Alessia, Sorrentino, Gabriele, Villa, Stefania, Cavalli, Riccardo, Mosca, Fabio, Plevani, Laura, Ghirardello, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700699/
https://www.ncbi.nlm.nih.gov/pubmed/34943275
http://dx.doi.org/10.3390/children8121079
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author Ferrario, Silvia
Zorz, Alessia
Sorrentino, Gabriele
Villa, Stefania
Cavalli, Riccardo
Mosca, Fabio
Plevani, Laura
Ghirardello, Stefano
author_facet Ferrario, Silvia
Zorz, Alessia
Sorrentino, Gabriele
Villa, Stefania
Cavalli, Riccardo
Mosca, Fabio
Plevani, Laura
Ghirardello, Stefano
author_sort Ferrario, Silvia
collection PubMed
description Background: A Pressure Ulcer (PU) is a severe event and could create discomfort to newborns. In newborns, one of mostly stricken location by PU is occipital area. Recent studies have highlighted that Cord Blood Platelet Gel (CBPG) might be a better alternative compared to traditional treatment. We report two cases of occipital PU treated with CBPG. Case report: Two male infants showing occipital PU were treated with standard local treatment, but no improvement was observed. After parental informed consent was obtained, CBPG application on PU was performed every 48 h. In these two cases of PU, a fast improvement in healing was observed since the first application of CBPG. The PU healed resulted in a scar after 53 and 50 days (Case 1 and Case 2, respectively) from development. No complications or infections were reported. Conclusions: CBPG contains many angiogenetic and growth factors, these characteristics make it indicated in treating soft tissue injuries. It would seem to be safe and an effective treatment of neonatal PUs reducing the time of the healing and the hospitalization and the infectious risks. Further studies are needed to evaluate long term aesthetic and functional results of PU treated with CBPG.
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spelling pubmed-87006992021-12-24 Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases Ferrario, Silvia Zorz, Alessia Sorrentino, Gabriele Villa, Stefania Cavalli, Riccardo Mosca, Fabio Plevani, Laura Ghirardello, Stefano Children (Basel) Case Report Background: A Pressure Ulcer (PU) is a severe event and could create discomfort to newborns. In newborns, one of mostly stricken location by PU is occipital area. Recent studies have highlighted that Cord Blood Platelet Gel (CBPG) might be a better alternative compared to traditional treatment. We report two cases of occipital PU treated with CBPG. Case report: Two male infants showing occipital PU were treated with standard local treatment, but no improvement was observed. After parental informed consent was obtained, CBPG application on PU was performed every 48 h. In these two cases of PU, a fast improvement in healing was observed since the first application of CBPG. The PU healed resulted in a scar after 53 and 50 days (Case 1 and Case 2, respectively) from development. No complications or infections were reported. Conclusions: CBPG contains many angiogenetic and growth factors, these characteristics make it indicated in treating soft tissue injuries. It would seem to be safe and an effective treatment of neonatal PUs reducing the time of the healing and the hospitalization and the infectious risks. Further studies are needed to evaluate long term aesthetic and functional results of PU treated with CBPG. MDPI 2021-11-23 /pmc/articles/PMC8700699/ /pubmed/34943275 http://dx.doi.org/10.3390/children8121079 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Ferrario, Silvia
Zorz, Alessia
Sorrentino, Gabriele
Villa, Stefania
Cavalli, Riccardo
Mosca, Fabio
Plevani, Laura
Ghirardello, Stefano
Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases
title Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases
title_full Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases
title_fullStr Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases
title_full_unstemmed Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases
title_short Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases
title_sort cord blood platelet gel as a treatment of occipital pressure injuries in newborns: report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700699/
https://www.ncbi.nlm.nih.gov/pubmed/34943275
http://dx.doi.org/10.3390/children8121079
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