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Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics

In modern societies, ageing and obesity represent medical challenges for healthcare professionals and caregivers. Obesity and ageing share common features including the related cellular and molecular pathways as well as the impacts they have as risk factors for a variety of diseases and health probl...

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Autores principales: Ghanemi, Abdelaziz, Yoshioka, Mayumi, St-Amand, Jonny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700721/
https://www.ncbi.nlm.nih.gov/pubmed/34940025
http://dx.doi.org/10.3390/diseases9040087
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author Ghanemi, Abdelaziz
Yoshioka, Mayumi
St-Amand, Jonny
author_facet Ghanemi, Abdelaziz
Yoshioka, Mayumi
St-Amand, Jonny
author_sort Ghanemi, Abdelaziz
collection PubMed
description In modern societies, ageing and obesity represent medical challenges for healthcare professionals and caregivers. Obesity and ageing share common features including the related cellular and molecular pathways as well as the impacts they have as risk factors for a variety of diseases and health problems. Both of these health problems also share exercise and a healthy lifestyle as the best therapeutic options. Importantly, ageing and obesity also have common epigenetic changes (histone modification, DNA methylation, noncoding RNAs, and chromatin remodeling) that are also impacted by exercise. This suggests that epigenetic pathways are among the mechanisms via which exercise induces its benefits, including ageing and obesity improvements. Exploring these interrelations and based on the fact that both ageing and obesity represent risk factors for each other, would lead to optimizing the available therapeutic approaches towards improved obesity management and healthy ageing.
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spelling pubmed-87007212021-12-24 Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics Ghanemi, Abdelaziz Yoshioka, Mayumi St-Amand, Jonny Diseases Opinion In modern societies, ageing and obesity represent medical challenges for healthcare professionals and caregivers. Obesity and ageing share common features including the related cellular and molecular pathways as well as the impacts they have as risk factors for a variety of diseases and health problems. Both of these health problems also share exercise and a healthy lifestyle as the best therapeutic options. Importantly, ageing and obesity also have common epigenetic changes (histone modification, DNA methylation, noncoding RNAs, and chromatin remodeling) that are also impacted by exercise. This suggests that epigenetic pathways are among the mechanisms via which exercise induces its benefits, including ageing and obesity improvements. Exploring these interrelations and based on the fact that both ageing and obesity represent risk factors for each other, would lead to optimizing the available therapeutic approaches towards improved obesity management and healthy ageing. MDPI 2021-11-29 /pmc/articles/PMC8700721/ /pubmed/34940025 http://dx.doi.org/10.3390/diseases9040087 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Ghanemi, Abdelaziz
Yoshioka, Mayumi
St-Amand, Jonny
Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics
title Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics
title_full Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics
title_fullStr Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics
title_full_unstemmed Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics
title_short Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics
title_sort ageing and obesity shared patterns: from molecular pathogenesis to epigenetics
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700721/
https://www.ncbi.nlm.nih.gov/pubmed/34940025
http://dx.doi.org/10.3390/diseases9040087
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