The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor prognosis, leading to significant cancer-related mortality and an overall five-year survival rate of about nine percent. Acute and chronic pancreatitis have been associated with PDAC through common risk factors based on multiple e...

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Autores principales: Alhobayb, Tamara, Peravali, Rahul, Ashkar, Motaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700754/
https://www.ncbi.nlm.nih.gov/pubmed/34940031
http://dx.doi.org/10.3390/diseases9040093
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author Alhobayb, Tamara
Peravali, Rahul
Ashkar, Motaz
author_facet Alhobayb, Tamara
Peravali, Rahul
Ashkar, Motaz
author_sort Alhobayb, Tamara
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor prognosis, leading to significant cancer-related mortality and an overall five-year survival rate of about nine percent. Acute and chronic pancreatitis have been associated with PDAC through common risk factors based on multiple epidemiological studies. Acute pancreatitis (AP) might be one of the earliest manifestations of PDAC, but evolving chronic pancreatitis (CP) following recurrent bouts of AP has been proposed as a risk factor for cancer development in the setting of persistent inflammation and ongoing exposure to carcinogens. This review aims to highlight the evidence supporting the relationship between acute and chronic pancreatitis with PDAC.
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spelling pubmed-87007542021-12-24 The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review Alhobayb, Tamara Peravali, Rahul Ashkar, Motaz Diseases Review Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor prognosis, leading to significant cancer-related mortality and an overall five-year survival rate of about nine percent. Acute and chronic pancreatitis have been associated with PDAC through common risk factors based on multiple epidemiological studies. Acute pancreatitis (AP) might be one of the earliest manifestations of PDAC, but evolving chronic pancreatitis (CP) following recurrent bouts of AP has been proposed as a risk factor for cancer development in the setting of persistent inflammation and ongoing exposure to carcinogens. This review aims to highlight the evidence supporting the relationship between acute and chronic pancreatitis with PDAC. MDPI 2021-12-20 /pmc/articles/PMC8700754/ /pubmed/34940031 http://dx.doi.org/10.3390/diseases9040093 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alhobayb, Tamara
Peravali, Rahul
Ashkar, Motaz
The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review
title The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review
title_full The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review
title_fullStr The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review
title_full_unstemmed The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review
title_short The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review
title_sort relationship between acute and chronic pancreatitis with pancreatic adenocarcinoma: review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700754/
https://www.ncbi.nlm.nih.gov/pubmed/34940031
http://dx.doi.org/10.3390/diseases9040093
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