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Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach
Biopolymer-based aerogels are open three-dimensional porous materials that are characterized by outstanding properties, such as a low density, high porosity and high surface area, in addition to their biocompatibility and non-cytotoxicity. Here we fabricated pure and binary blended aerogels from cel...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701007/ https://www.ncbi.nlm.nih.gov/pubmed/34940306 http://dx.doi.org/10.3390/gels7040246 |
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author | Rizal, Samsul Yahya, Esam Bashir Abdul Khalil, H. P. S. Abdullah, C. K. Marwan, Marwan Ikramullah, Ikramullah Muksin, Umar |
author_facet | Rizal, Samsul Yahya, Esam Bashir Abdul Khalil, H. P. S. Abdullah, C. K. Marwan, Marwan Ikramullah, Ikramullah Muksin, Umar |
author_sort | Rizal, Samsul |
collection | PubMed |
description | Biopolymer-based aerogels are open three-dimensional porous materials that are characterized by outstanding properties, such as a low density, high porosity and high surface area, in addition to their biocompatibility and non-cytotoxicity. Here we fabricated pure and binary blended aerogels from cellulose nanofibers (CNFs) and chitosan (CS), using a chemical-free approach that consists of high-pressure homogenization and freeze-drying. The prepared aerogels showed a different porosity and density, depending on the material and mixing ratio. The porosity and density of the aerogels ranged from 99.1 to 90.8% and from 0.0081 to 0.141 g/cm(3), respectively. Pure CNFs aerogel had the highest porosity and lightest density, but it showed poor mechanical properties and a high water absorption capacity. Mixing CS with CNFs significantly enhance the mechanical properties and reduce its water uptake. The two investigated ratios of aerogel blends had superior mechanical and thermal properties over the single-material aerogels, in addition to reduced water uptake and 2-log antibacterial activity. This green fabrication and chemical-free approach could have great potential in the preparation of biopolymeric scaffolds for different biomedical applications, such as tissue-engineering scaffolds. |
format | Online Article Text |
id | pubmed-8701007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87010072021-12-24 Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach Rizal, Samsul Yahya, Esam Bashir Abdul Khalil, H. P. S. Abdullah, C. K. Marwan, Marwan Ikramullah, Ikramullah Muksin, Umar Gels Article Biopolymer-based aerogels are open three-dimensional porous materials that are characterized by outstanding properties, such as a low density, high porosity and high surface area, in addition to their biocompatibility and non-cytotoxicity. Here we fabricated pure and binary blended aerogels from cellulose nanofibers (CNFs) and chitosan (CS), using a chemical-free approach that consists of high-pressure homogenization and freeze-drying. The prepared aerogels showed a different porosity and density, depending on the material and mixing ratio. The porosity and density of the aerogels ranged from 99.1 to 90.8% and from 0.0081 to 0.141 g/cm(3), respectively. Pure CNFs aerogel had the highest porosity and lightest density, but it showed poor mechanical properties and a high water absorption capacity. Mixing CS with CNFs significantly enhance the mechanical properties and reduce its water uptake. The two investigated ratios of aerogel blends had superior mechanical and thermal properties over the single-material aerogels, in addition to reduced water uptake and 2-log antibacterial activity. This green fabrication and chemical-free approach could have great potential in the preparation of biopolymeric scaffolds for different biomedical applications, such as tissue-engineering scaffolds. MDPI 2021-12-02 /pmc/articles/PMC8701007/ /pubmed/34940306 http://dx.doi.org/10.3390/gels7040246 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rizal, Samsul Yahya, Esam Bashir Abdul Khalil, H. P. S. Abdullah, C. K. Marwan, Marwan Ikramullah, Ikramullah Muksin, Umar Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach |
title | Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach |
title_full | Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach |
title_fullStr | Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach |
title_full_unstemmed | Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach |
title_short | Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach |
title_sort | preparation and characterization of nanocellulose/chitosan aerogel scaffolds using chemical-free approach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701007/ https://www.ncbi.nlm.nih.gov/pubmed/34940306 http://dx.doi.org/10.3390/gels7040246 |
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