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Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach

Biopolymer-based aerogels are open three-dimensional porous materials that are characterized by outstanding properties, such as a low density, high porosity and high surface area, in addition to their biocompatibility and non-cytotoxicity. Here we fabricated pure and binary blended aerogels from cel...

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Autores principales: Rizal, Samsul, Yahya, Esam Bashir, Abdul Khalil, H. P. S., Abdullah, C. K., Marwan, Marwan, Ikramullah, Ikramullah, Muksin, Umar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701007/
https://www.ncbi.nlm.nih.gov/pubmed/34940306
http://dx.doi.org/10.3390/gels7040246
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author Rizal, Samsul
Yahya, Esam Bashir
Abdul Khalil, H. P. S.
Abdullah, C. K.
Marwan, Marwan
Ikramullah, Ikramullah
Muksin, Umar
author_facet Rizal, Samsul
Yahya, Esam Bashir
Abdul Khalil, H. P. S.
Abdullah, C. K.
Marwan, Marwan
Ikramullah, Ikramullah
Muksin, Umar
author_sort Rizal, Samsul
collection PubMed
description Biopolymer-based aerogels are open three-dimensional porous materials that are characterized by outstanding properties, such as a low density, high porosity and high surface area, in addition to their biocompatibility and non-cytotoxicity. Here we fabricated pure and binary blended aerogels from cellulose nanofibers (CNFs) and chitosan (CS), using a chemical-free approach that consists of high-pressure homogenization and freeze-drying. The prepared aerogels showed a different porosity and density, depending on the material and mixing ratio. The porosity and density of the aerogels ranged from 99.1 to 90.8% and from 0.0081 to 0.141 g/cm(3), respectively. Pure CNFs aerogel had the highest porosity and lightest density, but it showed poor mechanical properties and a high water absorption capacity. Mixing CS with CNFs significantly enhance the mechanical properties and reduce its water uptake. The two investigated ratios of aerogel blends had superior mechanical and thermal properties over the single-material aerogels, in addition to reduced water uptake and 2-log antibacterial activity. This green fabrication and chemical-free approach could have great potential in the preparation of biopolymeric scaffolds for different biomedical applications, such as tissue-engineering scaffolds.
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spelling pubmed-87010072021-12-24 Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach Rizal, Samsul Yahya, Esam Bashir Abdul Khalil, H. P. S. Abdullah, C. K. Marwan, Marwan Ikramullah, Ikramullah Muksin, Umar Gels Article Biopolymer-based aerogels are open three-dimensional porous materials that are characterized by outstanding properties, such as a low density, high porosity and high surface area, in addition to their biocompatibility and non-cytotoxicity. Here we fabricated pure and binary blended aerogels from cellulose nanofibers (CNFs) and chitosan (CS), using a chemical-free approach that consists of high-pressure homogenization and freeze-drying. The prepared aerogels showed a different porosity and density, depending on the material and mixing ratio. The porosity and density of the aerogels ranged from 99.1 to 90.8% and from 0.0081 to 0.141 g/cm(3), respectively. Pure CNFs aerogel had the highest porosity and lightest density, but it showed poor mechanical properties and a high water absorption capacity. Mixing CS with CNFs significantly enhance the mechanical properties and reduce its water uptake. The two investigated ratios of aerogel blends had superior mechanical and thermal properties over the single-material aerogels, in addition to reduced water uptake and 2-log antibacterial activity. This green fabrication and chemical-free approach could have great potential in the preparation of biopolymeric scaffolds for different biomedical applications, such as tissue-engineering scaffolds. MDPI 2021-12-02 /pmc/articles/PMC8701007/ /pubmed/34940306 http://dx.doi.org/10.3390/gels7040246 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rizal, Samsul
Yahya, Esam Bashir
Abdul Khalil, H. P. S.
Abdullah, C. K.
Marwan, Marwan
Ikramullah, Ikramullah
Muksin, Umar
Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach
title Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach
title_full Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach
title_fullStr Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach
title_full_unstemmed Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach
title_short Preparation and Characterization of Nanocellulose/Chitosan Aerogel Scaffolds Using Chemical-Free Approach
title_sort preparation and characterization of nanocellulose/chitosan aerogel scaffolds using chemical-free approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701007/
https://www.ncbi.nlm.nih.gov/pubmed/34940306
http://dx.doi.org/10.3390/gels7040246
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