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Towards a Mathematical Model for the Viral Progression in the Pharynx

In this work, a comprehensive model for the viral progression in the pharynx has been developed. This one-dimension model considers both Fickian diffusion and convective flow coupled with chemical reactions, such as virus population growth, infected and uninfected cell accumulation as well as virus...

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Detalles Bibliográficos
Autores principales: Arya, Raj Kumar, Verros, George D., Thapliyal, Devyani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701019/
https://www.ncbi.nlm.nih.gov/pubmed/34946492
http://dx.doi.org/10.3390/healthcare9121766
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author Arya, Raj Kumar
Verros, George D.
Thapliyal, Devyani
author_facet Arya, Raj Kumar
Verros, George D.
Thapliyal, Devyani
author_sort Arya, Raj Kumar
collection PubMed
description In this work, a comprehensive model for the viral progression in the pharynx has been developed. This one-dimension model considers both Fickian diffusion and convective flow coupled with chemical reactions, such as virus population growth, infected and uninfected cell accumulation as well as virus clearance. The effect of a sterilizing agent such as an alcoholic solution on the viral progression in the pharynx was taken into account and a parametric analysis for the effect of kinetic rate parameters on virus propagation was made. Moreover, different conditions caused by further medical treatment, such as a decrease in virus yield per infected cell, were examined. It is shown that the infection fails to establish by decreasing the virus yield per infected cell. It is believed that this work could be used to further investigate the medical treatment of viral progression in the pharynx.
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spelling pubmed-87010192021-12-24 Towards a Mathematical Model for the Viral Progression in the Pharynx Arya, Raj Kumar Verros, George D. Thapliyal, Devyani Healthcare (Basel) Article In this work, a comprehensive model for the viral progression in the pharynx has been developed. This one-dimension model considers both Fickian diffusion and convective flow coupled with chemical reactions, such as virus population growth, infected and uninfected cell accumulation as well as virus clearance. The effect of a sterilizing agent such as an alcoholic solution on the viral progression in the pharynx was taken into account and a parametric analysis for the effect of kinetic rate parameters on virus propagation was made. Moreover, different conditions caused by further medical treatment, such as a decrease in virus yield per infected cell, were examined. It is shown that the infection fails to establish by decreasing the virus yield per infected cell. It is believed that this work could be used to further investigate the medical treatment of viral progression in the pharynx. MDPI 2021-12-20 /pmc/articles/PMC8701019/ /pubmed/34946492 http://dx.doi.org/10.3390/healthcare9121766 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arya, Raj Kumar
Verros, George D.
Thapliyal, Devyani
Towards a Mathematical Model for the Viral Progression in the Pharynx
title Towards a Mathematical Model for the Viral Progression in the Pharynx
title_full Towards a Mathematical Model for the Viral Progression in the Pharynx
title_fullStr Towards a Mathematical Model for the Viral Progression in the Pharynx
title_full_unstemmed Towards a Mathematical Model for the Viral Progression in the Pharynx
title_short Towards a Mathematical Model for the Viral Progression in the Pharynx
title_sort towards a mathematical model for the viral progression in the pharynx
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701019/
https://www.ncbi.nlm.nih.gov/pubmed/34946492
http://dx.doi.org/10.3390/healthcare9121766
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