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Towards a Mathematical Model for the Viral Progression in the Pharynx
In this work, a comprehensive model for the viral progression in the pharynx has been developed. This one-dimension model considers both Fickian diffusion and convective flow coupled with chemical reactions, such as virus population growth, infected and uninfected cell accumulation as well as virus...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701019/ https://www.ncbi.nlm.nih.gov/pubmed/34946492 http://dx.doi.org/10.3390/healthcare9121766 |
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author | Arya, Raj Kumar Verros, George D. Thapliyal, Devyani |
author_facet | Arya, Raj Kumar Verros, George D. Thapliyal, Devyani |
author_sort | Arya, Raj Kumar |
collection | PubMed |
description | In this work, a comprehensive model for the viral progression in the pharynx has been developed. This one-dimension model considers both Fickian diffusion and convective flow coupled with chemical reactions, such as virus population growth, infected and uninfected cell accumulation as well as virus clearance. The effect of a sterilizing agent such as an alcoholic solution on the viral progression in the pharynx was taken into account and a parametric analysis for the effect of kinetic rate parameters on virus propagation was made. Moreover, different conditions caused by further medical treatment, such as a decrease in virus yield per infected cell, were examined. It is shown that the infection fails to establish by decreasing the virus yield per infected cell. It is believed that this work could be used to further investigate the medical treatment of viral progression in the pharynx. |
format | Online Article Text |
id | pubmed-8701019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87010192021-12-24 Towards a Mathematical Model for the Viral Progression in the Pharynx Arya, Raj Kumar Verros, George D. Thapliyal, Devyani Healthcare (Basel) Article In this work, a comprehensive model for the viral progression in the pharynx has been developed. This one-dimension model considers both Fickian diffusion and convective flow coupled with chemical reactions, such as virus population growth, infected and uninfected cell accumulation as well as virus clearance. The effect of a sterilizing agent such as an alcoholic solution on the viral progression in the pharynx was taken into account and a parametric analysis for the effect of kinetic rate parameters on virus propagation was made. Moreover, different conditions caused by further medical treatment, such as a decrease in virus yield per infected cell, were examined. It is shown that the infection fails to establish by decreasing the virus yield per infected cell. It is believed that this work could be used to further investigate the medical treatment of viral progression in the pharynx. MDPI 2021-12-20 /pmc/articles/PMC8701019/ /pubmed/34946492 http://dx.doi.org/10.3390/healthcare9121766 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Arya, Raj Kumar Verros, George D. Thapliyal, Devyani Towards a Mathematical Model for the Viral Progression in the Pharynx |
title | Towards a Mathematical Model for the Viral Progression in the Pharynx |
title_full | Towards a Mathematical Model for the Viral Progression in the Pharynx |
title_fullStr | Towards a Mathematical Model for the Viral Progression in the Pharynx |
title_full_unstemmed | Towards a Mathematical Model for the Viral Progression in the Pharynx |
title_short | Towards a Mathematical Model for the Viral Progression in the Pharynx |
title_sort | towards a mathematical model for the viral progression in the pharynx |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701019/ https://www.ncbi.nlm.nih.gov/pubmed/34946492 http://dx.doi.org/10.3390/healthcare9121766 |
work_keys_str_mv | AT aryarajkumar towardsamathematicalmodelfortheviralprogressioninthepharynx AT verrosgeorged towardsamathematicalmodelfortheviralprogressioninthepharynx AT thapliyaldevyani towardsamathematicalmodelfortheviralprogressioninthepharynx |