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Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma
Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701026/ https://www.ncbi.nlm.nih.gov/pubmed/34948520 http://dx.doi.org/10.3390/ijerph182412911 |
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author | Feola, Alessandro Ciamarra, Paola De Simone, Mariavictoria Carfora, Anna Mansueto, Gelsomina Campobasso, Carlo Pietro |
author_facet | Feola, Alessandro Ciamarra, Paola De Simone, Mariavictoria Carfora, Anna Mansueto, Gelsomina Campobasso, Carlo Pietro |
author_sort | Feola, Alessandro |
collection | PubMed |
description | Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a rare malignant nodal or extranodal tumour with histiocytic immunophenotype that originates from a lymphohematopoietic precursor. The patients with HS usually have a poor prognosis due to its aggressive clinical behaviour. Rare cases of undiagnosed sudden HS death have been described in the literature. Methods: A forensic autopsy of a 46-year-old white male who died at home suddenly and unexpectedly without warning conditions or known diseases. Gross analysis, histology and toxicology were also performed. Results: The diagnosis of HS of the ileum with secondary nodal and cardiac metastatization was made. Conclusions: A prompt diagnosis of HS in life is paramount because it can make a difference in prognostic outcomes. |
format | Online Article Text |
id | pubmed-8701026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87010262021-12-24 Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma Feola, Alessandro Ciamarra, Paola De Simone, Mariavictoria Carfora, Anna Mansueto, Gelsomina Campobasso, Carlo Pietro Int J Environ Res Public Health Case Report Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a rare malignant nodal or extranodal tumour with histiocytic immunophenotype that originates from a lymphohematopoietic precursor. The patients with HS usually have a poor prognosis due to its aggressive clinical behaviour. Rare cases of undiagnosed sudden HS death have been described in the literature. Methods: A forensic autopsy of a 46-year-old white male who died at home suddenly and unexpectedly without warning conditions or known diseases. Gross analysis, histology and toxicology were also performed. Results: The diagnosis of HS of the ileum with secondary nodal and cardiac metastatization was made. Conclusions: A prompt diagnosis of HS in life is paramount because it can make a difference in prognostic outcomes. MDPI 2021-12-07 /pmc/articles/PMC8701026/ /pubmed/34948520 http://dx.doi.org/10.3390/ijerph182412911 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Feola, Alessandro Ciamarra, Paola De Simone, Mariavictoria Carfora, Anna Mansueto, Gelsomina Campobasso, Carlo Pietro Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma |
title | Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma |
title_full | Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma |
title_fullStr | Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma |
title_full_unstemmed | Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma |
title_short | Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma |
title_sort | sudden unexpected death caused by cardiac metastasization from histiocytic sarcoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701026/ https://www.ncbi.nlm.nih.gov/pubmed/34948520 http://dx.doi.org/10.3390/ijerph182412911 |
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