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Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma

Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a...

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Autores principales: Feola, Alessandro, Ciamarra, Paola, De Simone, Mariavictoria, Carfora, Anna, Mansueto, Gelsomina, Campobasso, Carlo Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701026/
https://www.ncbi.nlm.nih.gov/pubmed/34948520
http://dx.doi.org/10.3390/ijerph182412911
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author Feola, Alessandro
Ciamarra, Paola
De Simone, Mariavictoria
Carfora, Anna
Mansueto, Gelsomina
Campobasso, Carlo Pietro
author_facet Feola, Alessandro
Ciamarra, Paola
De Simone, Mariavictoria
Carfora, Anna
Mansueto, Gelsomina
Campobasso, Carlo Pietro
author_sort Feola, Alessandro
collection PubMed
description Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a rare malignant nodal or extranodal tumour with histiocytic immunophenotype that originates from a lymphohematopoietic precursor. The patients with HS usually have a poor prognosis due to its aggressive clinical behaviour. Rare cases of undiagnosed sudden HS death have been described in the literature. Methods: A forensic autopsy of a 46-year-old white male who died at home suddenly and unexpectedly without warning conditions or known diseases. Gross analysis, histology and toxicology were also performed. Results: The diagnosis of HS of the ileum with secondary nodal and cardiac metastatization was made. Conclusions: A prompt diagnosis of HS in life is paramount because it can make a difference in prognostic outcomes.
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spelling pubmed-87010262021-12-24 Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma Feola, Alessandro Ciamarra, Paola De Simone, Mariavictoria Carfora, Anna Mansueto, Gelsomina Campobasso, Carlo Pietro Int J Environ Res Public Health Case Report Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a rare malignant nodal or extranodal tumour with histiocytic immunophenotype that originates from a lymphohematopoietic precursor. The patients with HS usually have a poor prognosis due to its aggressive clinical behaviour. Rare cases of undiagnosed sudden HS death have been described in the literature. Methods: A forensic autopsy of a 46-year-old white male who died at home suddenly and unexpectedly without warning conditions or known diseases. Gross analysis, histology and toxicology were also performed. Results: The diagnosis of HS of the ileum with secondary nodal and cardiac metastatization was made. Conclusions: A prompt diagnosis of HS in life is paramount because it can make a difference in prognostic outcomes. MDPI 2021-12-07 /pmc/articles/PMC8701026/ /pubmed/34948520 http://dx.doi.org/10.3390/ijerph182412911 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Feola, Alessandro
Ciamarra, Paola
De Simone, Mariavictoria
Carfora, Anna
Mansueto, Gelsomina
Campobasso, Carlo Pietro
Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma
title Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma
title_full Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma
title_fullStr Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma
title_full_unstemmed Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma
title_short Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma
title_sort sudden unexpected death caused by cardiac metastasization from histiocytic sarcoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701026/
https://www.ncbi.nlm.nih.gov/pubmed/34948520
http://dx.doi.org/10.3390/ijerph182412911
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