Nucleic Acid-Sensing and Interferon-Inducible Pathways Show Differential Methylation in MZ Twins Discordant for Lupus and Overexpression in Independent Lupus Samples: Implications for Pathogenic Mechanism and Drug Targeting

Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune inflammatory disease with genomic and non-genomic contributions to risk. We hypothesize that epigenetic factors are a significant contributor to SLE risk and may be informative for identifying pathogenic mechanisms and therapeu...

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Detalles Bibliográficos
Autores principales: Marion, Miranda C., Ramos, Paula S., Bachali, Prathyusha, Labonte, Adam C., Zimmerman, Kip D., Ainsworth, Hannah C., Heuer, Sarah E., Robl, Robert D., Catalina, Michelle D., Kelly, Jennifer A., Howard, Timothy D., Lipsky, Peter E., Grammer, Amrie C., Langefeld, Carl D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701117/
https://www.ncbi.nlm.nih.gov/pubmed/34946847
http://dx.doi.org/10.3390/genes12121898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701117/
https://www.ncbi.nlm.nih.gov/pubmed/34946847
http://dx.doi.org/10.3390/genes12121898

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