Cargando…

Extra Corporeal Membrane Oxygenation in the Treatment of Human Immunodeficiency Virus-Related P. jirovecii Pneumonia

Despite the undeniable complexity one may encounter while managing critically ill patients with human immunodeficiency virus infection (HIV), intensive care unit-related mortality has declined in recent years, not only because of more efficacious antiretroviral therapy (ART) but also due to the adva...

Descripción completa

Detalles Bibliográficos
Autores principales: Lacerda Pereira, Sara, Branco, Elsa, Faustino, Ana Sofia, Figueiredo, Paulo, Sarmento, António, Santos, Lurdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701217/
https://www.ncbi.nlm.nih.gov/pubmed/34940402
http://dx.doi.org/10.3390/idr13040092
_version_ 1784620946813878272
author Lacerda Pereira, Sara
Branco, Elsa
Faustino, Ana Sofia
Figueiredo, Paulo
Sarmento, António
Santos, Lurdes
author_facet Lacerda Pereira, Sara
Branco, Elsa
Faustino, Ana Sofia
Figueiredo, Paulo
Sarmento, António
Santos, Lurdes
author_sort Lacerda Pereira, Sara
collection PubMed
description Despite the undeniable complexity one may encounter while managing critically ill patients with human immunodeficiency virus infection (HIV), intensive care unit-related mortality has declined in recent years, not only because of more efficacious antiretroviral therapy (ART) but also due to the advances in critical support. However, the use of extracorporeal membrane oxygenation (ECMO) in these patients remains controversial. We report four cases of HIV-infected patients with Pneumocystis jirovecii pneumonia (PJP) and acute respiratory distress syndrome (ARDS) treated with ECMO support and discuss its indications and possible role in the prevention of barotrauma and ventilator- induced lung injury (VILI). The eventually favorable clinical course of the patients that we present suggests that although immune status is an important aspect in the decision to initiate ECMO support, this technology can provide real benefit in some patients with severe HIV-related refractory ARDS.
format Online
Article
Text
id pubmed-8701217
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87012172021-12-24 Extra Corporeal Membrane Oxygenation in the Treatment of Human Immunodeficiency Virus-Related P. jirovecii Pneumonia Lacerda Pereira, Sara Branco, Elsa Faustino, Ana Sofia Figueiredo, Paulo Sarmento, António Santos, Lurdes Infect Dis Rep Case Report Despite the undeniable complexity one may encounter while managing critically ill patients with human immunodeficiency virus infection (HIV), intensive care unit-related mortality has declined in recent years, not only because of more efficacious antiretroviral therapy (ART) but also due to the advances in critical support. However, the use of extracorporeal membrane oxygenation (ECMO) in these patients remains controversial. We report four cases of HIV-infected patients with Pneumocystis jirovecii pneumonia (PJP) and acute respiratory distress syndrome (ARDS) treated with ECMO support and discuss its indications and possible role in the prevention of barotrauma and ventilator- induced lung injury (VILI). The eventually favorable clinical course of the patients that we present suggests that although immune status is an important aspect in the decision to initiate ECMO support, this technology can provide real benefit in some patients with severe HIV-related refractory ARDS. MDPI 2021-12-02 /pmc/articles/PMC8701217/ /pubmed/34940402 http://dx.doi.org/10.3390/idr13040092 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Lacerda Pereira, Sara
Branco, Elsa
Faustino, Ana Sofia
Figueiredo, Paulo
Sarmento, António
Santos, Lurdes
Extra Corporeal Membrane Oxygenation in the Treatment of Human Immunodeficiency Virus-Related P. jirovecii Pneumonia
title Extra Corporeal Membrane Oxygenation in the Treatment of Human Immunodeficiency Virus-Related P. jirovecii Pneumonia
title_full Extra Corporeal Membrane Oxygenation in the Treatment of Human Immunodeficiency Virus-Related P. jirovecii Pneumonia
title_fullStr Extra Corporeal Membrane Oxygenation in the Treatment of Human Immunodeficiency Virus-Related P. jirovecii Pneumonia
title_full_unstemmed Extra Corporeal Membrane Oxygenation in the Treatment of Human Immunodeficiency Virus-Related P. jirovecii Pneumonia
title_short Extra Corporeal Membrane Oxygenation in the Treatment of Human Immunodeficiency Virus-Related P. jirovecii Pneumonia
title_sort extra corporeal membrane oxygenation in the treatment of human immunodeficiency virus-related p. jirovecii pneumonia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701217/
https://www.ncbi.nlm.nih.gov/pubmed/34940402
http://dx.doi.org/10.3390/idr13040092
work_keys_str_mv AT lacerdapereirasara extracorporealmembraneoxygenationinthetreatmentofhumanimmunodeficiencyvirusrelatedpjiroveciipneumonia
AT brancoelsa extracorporealmembraneoxygenationinthetreatmentofhumanimmunodeficiencyvirusrelatedpjiroveciipneumonia
AT faustinoanasofia extracorporealmembraneoxygenationinthetreatmentofhumanimmunodeficiencyvirusrelatedpjiroveciipneumonia
AT figueiredopaulo extracorporealmembraneoxygenationinthetreatmentofhumanimmunodeficiencyvirusrelatedpjiroveciipneumonia
AT sarmentoantonio extracorporealmembraneoxygenationinthetreatmentofhumanimmunodeficiencyvirusrelatedpjiroveciipneumonia
AT santoslurdes extracorporealmembraneoxygenationinthetreatmentofhumanimmunodeficiencyvirusrelatedpjiroveciipneumonia