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Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia

Background: SARS-CoV-2 infection has a high mortality rate and continues to be a global threat, which warrants the identification of all mortality risk factors in critically ill patients. Methods: This is a retrospective multicenter cohort study conducted in five hospitals in the Kingdom of Saudi Ar...

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Autores principales: Alhasan, Khalid A, Shalaby, Mohamed A, Temsah, Mohamad-Hani, Aljamaan, Fadi, Shagal, Reem, AlFaadhel, Talal, Alomi, Mohammed, AlMatham, Khalid, AlHerbish, Adi J., Raina, Rupesh, Sethi, Sidharth K., Alsubaie, Sarah, Hakami, Marwah H, Alharbi, Najla M, Shebeli, Razan A, Nur, Hanan Mohamed, Kashari, Ohoud F, Qari, Faiza A, Albanna, Amr S, Kari, Jameela A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701249/
https://www.ncbi.nlm.nih.gov/pubmed/34946347
http://dx.doi.org/10.3390/healthcare9121608
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author Alhasan, Khalid A
Shalaby, Mohamed A
Temsah, Mohamad-Hani
Aljamaan, Fadi
Shagal, Reem
AlFaadhel, Talal
Alomi, Mohammed
AlMatham, Khalid
AlHerbish, Adi J.
Raina, Rupesh
Sethi, Sidharth K.
Alsubaie, Sarah
Hakami, Marwah H
Alharbi, Najla M
Shebeli, Razan A
Nur, Hanan Mohamed
Kashari, Ohoud F
Qari, Faiza A
Albanna, Amr S
Kari, Jameela A
author_facet Alhasan, Khalid A
Shalaby, Mohamed A
Temsah, Mohamad-Hani
Aljamaan, Fadi
Shagal, Reem
AlFaadhel, Talal
Alomi, Mohammed
AlMatham, Khalid
AlHerbish, Adi J.
Raina, Rupesh
Sethi, Sidharth K.
Alsubaie, Sarah
Hakami, Marwah H
Alharbi, Najla M
Shebeli, Razan A
Nur, Hanan Mohamed
Kashari, Ohoud F
Qari, Faiza A
Albanna, Amr S
Kari, Jameela A
author_sort Alhasan, Khalid A
collection PubMed
description Background: SARS-CoV-2 infection has a high mortality rate and continues to be a global threat, which warrants the identification of all mortality risk factors in critically ill patients. Methods: This is a retrospective multicenter cohort study conducted in five hospitals in the Kingdom of Saudi Arabia (KSA). We enrolled patients with confirmed SARS-COV-2 infection admitted to any of the intensive care units from the five hospitals between March 2020 and July 2020, corresponding to the peak of recorded COVID-19 cases in the KSA. Results: In total, 229 critically ill patients with confirmed SARS-CoV-2 infection were included in the study. The presenting symptoms and signs of patients who died during hospitalization were not significantly different from those observed among patients who survived. The baseline comorbidities that were significantly associated with in-hospital mortality were diabetes (62% vs. 48% among patients who died and survived (p = 0.046)), underlying cardiac disease (38% vs. 19% (p = 0.001)), and underlying kidney disease (32% vs. 12% (p < 0.001)). Conclusion: In our cohort, the baseline comorbidities that were significantly associated with in-hospital mortality were diabetes, underlying cardiac disease, and underlying kidney disease. Additionally, the factors that independently influenced mortality among critically ill COVID-19 patients were high Activated Partial Thromboplastin Time (aPTT )and international normalization ratio (INR), acidosis, and high ferritin.
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spelling pubmed-87012492021-12-24 Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia Alhasan, Khalid A Shalaby, Mohamed A Temsah, Mohamad-Hani Aljamaan, Fadi Shagal, Reem AlFaadhel, Talal Alomi, Mohammed AlMatham, Khalid AlHerbish, Adi J. Raina, Rupesh Sethi, Sidharth K. Alsubaie, Sarah Hakami, Marwah H Alharbi, Najla M Shebeli, Razan A Nur, Hanan Mohamed Kashari, Ohoud F Qari, Faiza A Albanna, Amr S Kari, Jameela A Healthcare (Basel) Article Background: SARS-CoV-2 infection has a high mortality rate and continues to be a global threat, which warrants the identification of all mortality risk factors in critically ill patients. Methods: This is a retrospective multicenter cohort study conducted in five hospitals in the Kingdom of Saudi Arabia (KSA). We enrolled patients with confirmed SARS-COV-2 infection admitted to any of the intensive care units from the five hospitals between March 2020 and July 2020, corresponding to the peak of recorded COVID-19 cases in the KSA. Results: In total, 229 critically ill patients with confirmed SARS-CoV-2 infection were included in the study. The presenting symptoms and signs of patients who died during hospitalization were not significantly different from those observed among patients who survived. The baseline comorbidities that were significantly associated with in-hospital mortality were diabetes (62% vs. 48% among patients who died and survived (p = 0.046)), underlying cardiac disease (38% vs. 19% (p = 0.001)), and underlying kidney disease (32% vs. 12% (p < 0.001)). Conclusion: In our cohort, the baseline comorbidities that were significantly associated with in-hospital mortality were diabetes, underlying cardiac disease, and underlying kidney disease. Additionally, the factors that independently influenced mortality among critically ill COVID-19 patients were high Activated Partial Thromboplastin Time (aPTT )and international normalization ratio (INR), acidosis, and high ferritin. MDPI 2021-11-23 /pmc/articles/PMC8701249/ /pubmed/34946347 http://dx.doi.org/10.3390/healthcare9121608 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alhasan, Khalid A
Shalaby, Mohamed A
Temsah, Mohamad-Hani
Aljamaan, Fadi
Shagal, Reem
AlFaadhel, Talal
Alomi, Mohammed
AlMatham, Khalid
AlHerbish, Adi J.
Raina, Rupesh
Sethi, Sidharth K.
Alsubaie, Sarah
Hakami, Marwah H
Alharbi, Najla M
Shebeli, Razan A
Nur, Hanan Mohamed
Kashari, Ohoud F
Qari, Faiza A
Albanna, Amr S
Kari, Jameela A
Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia
title Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia
title_full Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia
title_fullStr Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia
title_full_unstemmed Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia
title_short Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia
title_sort factors that influence mortality in critically ill patients with sars-cov-2 infection: a multicenter study in the kingdom of saudi arabia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701249/
https://www.ncbi.nlm.nih.gov/pubmed/34946347
http://dx.doi.org/10.3390/healthcare9121608
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