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Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia
Background: SARS-CoV-2 infection has a high mortality rate and continues to be a global threat, which warrants the identification of all mortality risk factors in critically ill patients. Methods: This is a retrospective multicenter cohort study conducted in five hospitals in the Kingdom of Saudi Ar...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701249/ https://www.ncbi.nlm.nih.gov/pubmed/34946347 http://dx.doi.org/10.3390/healthcare9121608 |
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author | Alhasan, Khalid A Shalaby, Mohamed A Temsah, Mohamad-Hani Aljamaan, Fadi Shagal, Reem AlFaadhel, Talal Alomi, Mohammed AlMatham, Khalid AlHerbish, Adi J. Raina, Rupesh Sethi, Sidharth K. Alsubaie, Sarah Hakami, Marwah H Alharbi, Najla M Shebeli, Razan A Nur, Hanan Mohamed Kashari, Ohoud F Qari, Faiza A Albanna, Amr S Kari, Jameela A |
author_facet | Alhasan, Khalid A Shalaby, Mohamed A Temsah, Mohamad-Hani Aljamaan, Fadi Shagal, Reem AlFaadhel, Talal Alomi, Mohammed AlMatham, Khalid AlHerbish, Adi J. Raina, Rupesh Sethi, Sidharth K. Alsubaie, Sarah Hakami, Marwah H Alharbi, Najla M Shebeli, Razan A Nur, Hanan Mohamed Kashari, Ohoud F Qari, Faiza A Albanna, Amr S Kari, Jameela A |
author_sort | Alhasan, Khalid A |
collection | PubMed |
description | Background: SARS-CoV-2 infection has a high mortality rate and continues to be a global threat, which warrants the identification of all mortality risk factors in critically ill patients. Methods: This is a retrospective multicenter cohort study conducted in five hospitals in the Kingdom of Saudi Arabia (KSA). We enrolled patients with confirmed SARS-COV-2 infection admitted to any of the intensive care units from the five hospitals between March 2020 and July 2020, corresponding to the peak of recorded COVID-19 cases in the KSA. Results: In total, 229 critically ill patients with confirmed SARS-CoV-2 infection were included in the study. The presenting symptoms and signs of patients who died during hospitalization were not significantly different from those observed among patients who survived. The baseline comorbidities that were significantly associated with in-hospital mortality were diabetes (62% vs. 48% among patients who died and survived (p = 0.046)), underlying cardiac disease (38% vs. 19% (p = 0.001)), and underlying kidney disease (32% vs. 12% (p < 0.001)). Conclusion: In our cohort, the baseline comorbidities that were significantly associated with in-hospital mortality were diabetes, underlying cardiac disease, and underlying kidney disease. Additionally, the factors that independently influenced mortality among critically ill COVID-19 patients were high Activated Partial Thromboplastin Time (aPTT )and international normalization ratio (INR), acidosis, and high ferritin. |
format | Online Article Text |
id | pubmed-8701249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87012492021-12-24 Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia Alhasan, Khalid A Shalaby, Mohamed A Temsah, Mohamad-Hani Aljamaan, Fadi Shagal, Reem AlFaadhel, Talal Alomi, Mohammed AlMatham, Khalid AlHerbish, Adi J. Raina, Rupesh Sethi, Sidharth K. Alsubaie, Sarah Hakami, Marwah H Alharbi, Najla M Shebeli, Razan A Nur, Hanan Mohamed Kashari, Ohoud F Qari, Faiza A Albanna, Amr S Kari, Jameela A Healthcare (Basel) Article Background: SARS-CoV-2 infection has a high mortality rate and continues to be a global threat, which warrants the identification of all mortality risk factors in critically ill patients. Methods: This is a retrospective multicenter cohort study conducted in five hospitals in the Kingdom of Saudi Arabia (KSA). We enrolled patients with confirmed SARS-COV-2 infection admitted to any of the intensive care units from the five hospitals between March 2020 and July 2020, corresponding to the peak of recorded COVID-19 cases in the KSA. Results: In total, 229 critically ill patients with confirmed SARS-CoV-2 infection were included in the study. The presenting symptoms and signs of patients who died during hospitalization were not significantly different from those observed among patients who survived. The baseline comorbidities that were significantly associated with in-hospital mortality were diabetes (62% vs. 48% among patients who died and survived (p = 0.046)), underlying cardiac disease (38% vs. 19% (p = 0.001)), and underlying kidney disease (32% vs. 12% (p < 0.001)). Conclusion: In our cohort, the baseline comorbidities that were significantly associated with in-hospital mortality were diabetes, underlying cardiac disease, and underlying kidney disease. Additionally, the factors that independently influenced mortality among critically ill COVID-19 patients were high Activated Partial Thromboplastin Time (aPTT )and international normalization ratio (INR), acidosis, and high ferritin. MDPI 2021-11-23 /pmc/articles/PMC8701249/ /pubmed/34946347 http://dx.doi.org/10.3390/healthcare9121608 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alhasan, Khalid A Shalaby, Mohamed A Temsah, Mohamad-Hani Aljamaan, Fadi Shagal, Reem AlFaadhel, Talal Alomi, Mohammed AlMatham, Khalid AlHerbish, Adi J. Raina, Rupesh Sethi, Sidharth K. Alsubaie, Sarah Hakami, Marwah H Alharbi, Najla M Shebeli, Razan A Nur, Hanan Mohamed Kashari, Ohoud F Qari, Faiza A Albanna, Amr S Kari, Jameela A Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia |
title | Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia |
title_full | Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia |
title_fullStr | Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia |
title_full_unstemmed | Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia |
title_short | Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia |
title_sort | factors that influence mortality in critically ill patients with sars-cov-2 infection: a multicenter study in the kingdom of saudi arabia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701249/ https://www.ncbi.nlm.nih.gov/pubmed/34946347 http://dx.doi.org/10.3390/healthcare9121608 |
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