Loss of an Immunodominant HLA-Α *01:01 Restricted Epitope for CD8+ Cytotoxic T Lymphocytes (CTLs) in the Delta Variant of COVID-19: An Example of Immunologic Escape and Implications for Immunologic Treatment

SARS-COV-2 (COVID-19) has resulted in over 4 million deaths worldwide. While vaccination has decreased mortality, there remains a need for curative therapies for active infections. Uncertainties regarding the duration of post-vaccination immunity and the rapidity of mutational evolution by this viru...

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Detalles Bibliográficos
Autores principales: Flomenberg, Neal, Grosso, Dolores, Sykulev, Yuri, Anikeyeva, Nadezhda, Huang, Yanping, Sun, Michael, Keck, Kaitlin, O'Connor, Allyson, Peedin, Alexis, Karp, Julie, Flomenberg, Phyllis, Chang, AnnaMaria, Henwood, Patricia, Rising, Kristin, Nikbakht, Neda, McGuire, Liza, Flomenberg, Samuel, Saadi, Ryan, Wagner, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology. Published by Elsevier Inc. 2021
Materias:
703.Cellular Immunotherapies: Basic and Translational
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701634/
https://www.ncbi.nlm.nih.gov/pubmed/34436527
http://dx.doi.org/10.1182/blood-2021-147487

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