The Deglycosylated Form of 1E12, a Monoclonal Anti-PF4 IgG, Strongly Inhibits Antibody-Triggered Cellular Activation in Vaccine-Induced Thrombotic Thrombocytopenia, and Is a Potential New Treatment for Vιττ

Introduction Vaccine-induced thrombotic thrombocytopenia (VITT) is a severe complication of recombinant adenoviral vector vaccines used to prevent COVID-19, likely due to anti-platelet factor 4 (PF4) IgG antibodies. The specificity and platelet-activating activity of VITT antibodies strikingly resem...

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Detalles Bibliográficos
Autores principales: Vayne, Caroline, Palankar, Raghavendra, Billy, Sandra, Handtke, Stefan, Thiele, Thomas, Pouplard, Claire, Greinacher, Andreas, Gruel, Yves, Rollin, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology. Published by Elsevier Inc. 2021
Materias:
301.Vasculature, Endothelial Cells and Platelets: Basic and Translational
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701649/
http://dx.doi.org/10.1182/blood-2021-147922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701649/
http://dx.doi.org/10.1182/blood-2021-147922

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