Cargando…

The Deglycosylated Form of 1E12, a Monoclonal Anti-PF4 IgG, Strongly Inhibits Antibody-Triggered Cellular Activation in Vaccine-Induced Thrombotic Thrombocytopenia, and Is a Potential New Treatment for Vιττ

Introduction Vaccine-induced thrombotic thrombocytopenia (VITT) is a severe complication of recombinant adenoviral vector vaccines used to prevent COVID-19, likely due to anti-platelet factor 4 (PF4) IgG antibodies. The specificity and platelet-activating activity of VITT antibodies strikingly resem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vayne, Caroline, Palankar, Raghavendra, Billy, Sandra, Handtke, Stefan, Thiele, Thomas, Pouplard, Claire, Greinacher, Andreas, Gruel, Yves, Rollin, Jérôme
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology. Published by Elsevier Inc. 2021
Materias:	301.Vasculature, Endothelial Cells and Platelets: Basic and Translational
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701649/ http://dx.doi.org/10.1182/blood-2021-147922

Ejemplares similares

The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodies
por: Vayne, Caroline, et al.
Publicado: (2022)

The Role of PF4 Antibodies in Pediatric Sars-Cov-2 Infections
por: Chiem, Meady, et al.
Publicado: (2021)

Variable serotonin release assay pattern and specificity of PF4‐specific antibodies in HIT, and clinical relevance
por: Rollin, Jérôme, et al.
Publicado: (2022)

Sars-Cov-2 Induced Endotheliopathy and the Impact on Clinical Outcomes in Critically Ill Pediatric Patients
por: Agarwal, Shreya, et al.
Publicado: (2021)

Inhibition of Sars-Cov-2 Viral Replication and In Vivo Thrombus Formation By a Novel Plant Flavonoid
por: Yang, Moua, et al.
Publicado: (2021)

Circulating Levels of Ang/Tie2 and VEGF-a Pathway Mediators Are Associated with Clinical Severity, Endothelial Barrier Disruption and Coagulation Activation in COVID-19
por: de Moraes, Carla Roberta Peachazepi, et al.
Publicado: (2021)

Sars-Cov-2 Infection Promotes Endothelial Dysfunction and Thrombosis in a Mouse Model of COVID-19
por: Aiolfi, Roberto, et al.
Publicado: (2021)

PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia
por: Vayne, Caroline, et al.
Publicado: (2021)

Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia
por: Greinacher, Andreas, et al.
Publicado: (2021)

The interaction between anti-PF4 antibodies and anticoagulants in vaccine-induced thrombotic thrombocytopenia
por: Singh, Anurag, et al.
Publicado: (2022)

Genome-wide association study of platelet factor 4/heparin antibodies in heparin-induced thrombocytopenia
por: Giles, Jason B., et al.
Publicado: (2022)

Hospital Outcomes Among Covid-19 Hospitalizations With Myocarditis: Results From California State Inpatient Database
por: Carcamo, Francisco Javier Jimenez, et al.
Publicado: (2023)

The Copenhagen founder variant GP1BA c.58T>G is the most frequent cause of inherited thrombocytopenia in Denmark
por: Leinøe, Eva, et al.
Publicado: (2021)

Pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT)
por: Greinacher, Andreas, et al.
Publicado: (2022)

Biological stratification of clinical disease courses in childhood immune thrombocytopenia
por: Schmidt, David E., et al.
Publicado: (2021)

Successful treatment of vaccine‐induced prothrombotic immune thrombocytopenia (VIPIT)
por: Thaler, Johannes, et al.
Publicado: (2021)

The role of ADAMTS‐13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathies
por: Phillips, E. H., et al.
Publicado: (2016)

Anti‐platelet antibodies in childhood immune thrombocytopenia: Prevalence and prognostic implications
por: Schmidt, David E., et al.
Publicado: (2020)

Combinations of rapid immunoassays for a speedy diagnosis of heparin‐induced thrombocytopenia
por: Rittener‐Ruff, Luana, et al.
Publicado: (2022)

Treatment of acquired thrombotic thrombocytopenic purpura without plasma exchange in selected patients under caplacizumab
por: Völker, Linus A., et al.
Publicado: (2020)

Combination of two complementary automated rapid assays for diagnosis of heparin‐induced thrombocytopenia (HIT)
por: Warkentin, Theodore E., et al.
Publicado: (2020)

Measurement of procoagulant platelets provides mechanistic insight and diagnostic potential in heparin‐induced thrombocytopenia
por: Lee, Christine S. M., et al.
Publicado: (2022)

Most anti-PF4 antibodies in vaccine-induced immune thrombotic thrombocytopenia are transient
por: Schönborn, Linda, et al.
Publicado: (2022)

Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels
por: Douxfils, Jonathan, et al.
Publicado: (2021)

Hypothermia‐induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model
por: Horioka, Kie, et al.
Publicado: (2019)

Diagnostic uncertainty presented barriers to the timely management of acute thrombotic thrombocytopenic purpura in the United Kingdom between 2014 and 2019
Publicado: (2022)

GPVI expression is linked to platelet size, age, and reactivity
por: Veninga, Alicia, et al.
Publicado: (2022)

Temporal presentations of heparin‐induced thrombocytopenia following cardiac surgery: A single‐center, retrospective cohort study
por: Warkentin, Theodore E., et al.
Publicado: (2022)

A retrospective analysis of 122 immune thrombocytopenia patients treated with dapsone: Efficacy, safety and factors associated with treatment response
por: Colella, Marina P., et al.
Publicado: (2021)

Src-related thrombocytopenia: a fine line between a megakaryocyte dysfunction and an immune-mediated disease
por: Palma-Barqueros, Verónica, et al.
Publicado: (2022)

Treatment of thrombocytopenia and thrombosis in HIT in mice using deglycosylated KKO: a novel therapeutic?
por: Sarkar, Amrita, et al.
Publicado: (2023)

The Role of Fibrinolytic Factors, a Subset of Angiocrine Factors in Cytokine Storm-Associated Diseases
por: Hattori, Koichi, et al.
Publicado: (2020)

Evidence of Microangiopathy in Children with Sars-Cov-2 Regardless of Clinical Presentation
por: Diorio, Caroline, et al.
Publicado: (2020)

Circulating Biomarkers of COVID-19-Triggered Endotheliopathy: From Conjecture to Certainty
por: Moreno-Castaño, Ana Belen, et al.
Publicado: (2020)

Pathophysiology and Diagnosis of Drug-Induced Immune Thrombocytopenia
por: Vayne, Caroline, et al.
Publicado: (2020)

Surgical specimens, haemodynamics and long-term outcomes after pulmonary endarterectomy
por: Skoro-Sajer, Nika, et al.
Publicado: (2014)

Assessment of proximal pulmonary arterial stiffness using magnetic resonance imaging: effects of technique, age and exercise
por: Weir-McCall, Jonathan R, et al.
Publicado: (2016)

High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice
por: Schlosser, Kenny, et al.
Publicado: (2018)

Symptom severity and its effect on health-related quality of life over time in patients with pulmonary hypertension: a multisite longitudinal cohort study
por: Yorke, Janelle, et al.
Publicado: (2018)

Veterans Specific Activity Questionnaire (VSAQ): a new and efficient method of assessing exercise capacity in patients with pulmonary arteriovenous malformations
por: Gawecki, Filip, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ht8rji4k8vij7rllqeobqsmtfl