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Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach

Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In addition to their multipotency, stem cells possess immunomodulatory effects that can alleviate inflammation and enhance cartilage repair. However, the widely clinical application of stem cell therapy to ca...

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Autores principales: Liu, Yisi, Wang, Meng, Luo, Yixuan, Liang, Qianyi, Yu, Yin, Chen, Fei, Yao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701810/
https://www.ncbi.nlm.nih.gov/pubmed/34940323
http://dx.doi.org/10.3390/gels7040263
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author Liu, Yisi
Wang, Meng
Luo, Yixuan
Liang, Qianyi
Yu, Yin
Chen, Fei
Yao, Jun
author_facet Liu, Yisi
Wang, Meng
Luo, Yixuan
Liang, Qianyi
Yu, Yin
Chen, Fei
Yao, Jun
author_sort Liu, Yisi
collection PubMed
description Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In addition to their multipotency, stem cells possess immunomodulatory effects that can alleviate inflammation and enhance cartilage repair. However, the widely clinical application of stem cell therapy to cartilage repair and osteoarthritis has proven difficult due to challenges in large-scale production, viability maintenance in pathological tissue site and limited therapeutic biological activity. This review aims to provide a perspective from hydrogel-focused approach to address few key challenges in stem cell-based therapy for cartilage repair and highlight recent progress in advanced hydrogels, particularly microgels and dynamic hydrogels systems for improving stem cell survival, retention and regulation of stem cell fate. Finally, progress in hydrogel-assisted gene delivery and genome editing approaches for the development of next generation of stem cell therapy for cartilage repair in osteoarthritis are highlighted.
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spelling pubmed-87018102021-12-24 Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach Liu, Yisi Wang, Meng Luo, Yixuan Liang, Qianyi Yu, Yin Chen, Fei Yao, Jun Gels Review Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In addition to their multipotency, stem cells possess immunomodulatory effects that can alleviate inflammation and enhance cartilage repair. However, the widely clinical application of stem cell therapy to cartilage repair and osteoarthritis has proven difficult due to challenges in large-scale production, viability maintenance in pathological tissue site and limited therapeutic biological activity. This review aims to provide a perspective from hydrogel-focused approach to address few key challenges in stem cell-based therapy for cartilage repair and highlight recent progress in advanced hydrogels, particularly microgels and dynamic hydrogels systems for improving stem cell survival, retention and regulation of stem cell fate. Finally, progress in hydrogel-assisted gene delivery and genome editing approaches for the development of next generation of stem cell therapy for cartilage repair in osteoarthritis are highlighted. MDPI 2021-12-14 /pmc/articles/PMC8701810/ /pubmed/34940323 http://dx.doi.org/10.3390/gels7040263 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Yisi
Wang, Meng
Luo, Yixuan
Liang, Qianyi
Yu, Yin
Chen, Fei
Yao, Jun
Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach
title Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach
title_full Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach
title_fullStr Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach
title_full_unstemmed Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach
title_short Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach
title_sort enhancing stem cell therapy for cartilage repair in osteoarthritis—a hydrogel focused approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701810/
https://www.ncbi.nlm.nih.gov/pubmed/34940323
http://dx.doi.org/10.3390/gels7040263
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