Cargando…
Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
Background: In 2020, during the COVID-19 pandemic, Italy implemented two national lockdowns aimed at reducing virus transmission. We assessed whether these lockdowns affected anti-seizure medication (ASM) use and epilepsy-related access to emergency departments (ED) in the general population. Method...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701966/ https://www.ncbi.nlm.nih.gov/pubmed/34948862 http://dx.doi.org/10.3390/ijerph182413253 |
_version_ | 1784621131749130240 |
---|---|
author | Antonazzo, Ippazio Cosimo Fornari, Carla Maumus-Robert, Sandy Cei, Eleonora Paoletti, Olga Conti, Sara Cortesi, Paolo Angelo Mantovani, Lorenzo Giovanni Gini, Rosa Mazzaglia, Giampiero |
author_facet | Antonazzo, Ippazio Cosimo Fornari, Carla Maumus-Robert, Sandy Cei, Eleonora Paoletti, Olga Conti, Sara Cortesi, Paolo Angelo Mantovani, Lorenzo Giovanni Gini, Rosa Mazzaglia, Giampiero |
author_sort | Antonazzo, Ippazio Cosimo |
collection | PubMed |
description | Background: In 2020, during the COVID-19 pandemic, Italy implemented two national lockdowns aimed at reducing virus transmission. We assessed whether these lockdowns affected anti-seizure medication (ASM) use and epilepsy-related access to emergency departments (ED) in the general population. Methods: We performed a population-based study using the healthcare administrative database of Tuscany. We defined the weekly time series of prevalence and incidence of ASM, along with the incidence of epilepsy-related ED access from 1 January 2018 to 27 December 2020 in the general population. An interrupted time-series analysis was used to assess the effect of lockdowns on the observed outcomes. Results: Compared to pre-lockdown, we observed a relevant reduction of ASM incidence (0.65; 95% Confidence Intervals: 0.59–0.72) and ED access (0.72; 0.64–0.82), and a slight decrease of ASM prevalence (0.95; 0.94–0.96). During the post-lockdown the ASM incidence reported higher values compared to pre-lockdown, whereas ASM prevalence and ED access remained lower. Results also indicate a lower impact of the second lockdown for both ASM prevalence (0.97; 0.96–0.98) and incidence (0.89; 0.80–0.99). Conclusion: The lockdowns implemented during the COVID-19 outbreaks significantly affected ASM use and epilepsy-related ED access. The potential consequences of these phenomenon are still unknown, although an increased incidence of epilepsy-related symptoms after the first lockdown has been observed. These findings emphasize the need of ensuring continuous care of epileptic patients in stressful conditions such as the COVID-19 pandemic. |
format | Online Article Text |
id | pubmed-8701966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87019662021-12-24 Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis Antonazzo, Ippazio Cosimo Fornari, Carla Maumus-Robert, Sandy Cei, Eleonora Paoletti, Olga Conti, Sara Cortesi, Paolo Angelo Mantovani, Lorenzo Giovanni Gini, Rosa Mazzaglia, Giampiero Int J Environ Res Public Health Article Background: In 2020, during the COVID-19 pandemic, Italy implemented two national lockdowns aimed at reducing virus transmission. We assessed whether these lockdowns affected anti-seizure medication (ASM) use and epilepsy-related access to emergency departments (ED) in the general population. Methods: We performed a population-based study using the healthcare administrative database of Tuscany. We defined the weekly time series of prevalence and incidence of ASM, along with the incidence of epilepsy-related ED access from 1 January 2018 to 27 December 2020 in the general population. An interrupted time-series analysis was used to assess the effect of lockdowns on the observed outcomes. Results: Compared to pre-lockdown, we observed a relevant reduction of ASM incidence (0.65; 95% Confidence Intervals: 0.59–0.72) and ED access (0.72; 0.64–0.82), and a slight decrease of ASM prevalence (0.95; 0.94–0.96). During the post-lockdown the ASM incidence reported higher values compared to pre-lockdown, whereas ASM prevalence and ED access remained lower. Results also indicate a lower impact of the second lockdown for both ASM prevalence (0.97; 0.96–0.98) and incidence (0.89; 0.80–0.99). Conclusion: The lockdowns implemented during the COVID-19 outbreaks significantly affected ASM use and epilepsy-related ED access. The potential consequences of these phenomenon are still unknown, although an increased incidence of epilepsy-related symptoms after the first lockdown has been observed. These findings emphasize the need of ensuring continuous care of epileptic patients in stressful conditions such as the COVID-19 pandemic. MDPI 2021-12-16 /pmc/articles/PMC8701966/ /pubmed/34948862 http://dx.doi.org/10.3390/ijerph182413253 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Antonazzo, Ippazio Cosimo Fornari, Carla Maumus-Robert, Sandy Cei, Eleonora Paoletti, Olga Conti, Sara Cortesi, Paolo Angelo Mantovani, Lorenzo Giovanni Gini, Rosa Mazzaglia, Giampiero Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis |
title | Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis |
title_full | Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis |
title_fullStr | Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis |
title_full_unstemmed | Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis |
title_short | Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis |
title_sort | impact of covid-19 lockdown, during the two waves, on drug use and emergency department access in people with epilepsy: an interrupted time-series analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701966/ https://www.ncbi.nlm.nih.gov/pubmed/34948862 http://dx.doi.org/10.3390/ijerph182413253 |
work_keys_str_mv | AT antonazzoippaziocosimo impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis AT fornaricarla impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis AT maumusrobertsandy impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis AT ceieleonora impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis AT paolettiolga impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis AT contisara impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis AT cortesipaoloangelo impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis AT mantovanilorenzogiovanni impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis AT ginirosa impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis AT mazzagliagiampiero impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis |