Cargando…

Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis

Background: In 2020, during the COVID-19 pandemic, Italy implemented two national lockdowns aimed at reducing virus transmission. We assessed whether these lockdowns affected anti-seizure medication (ASM) use and epilepsy-related access to emergency departments (ED) in the general population. Method...

Descripción completa

Detalles Bibliográficos
Autores principales: Antonazzo, Ippazio Cosimo, Fornari, Carla, Maumus-Robert, Sandy, Cei, Eleonora, Paoletti, Olga, Conti, Sara, Cortesi, Paolo Angelo, Mantovani, Lorenzo Giovanni, Gini, Rosa, Mazzaglia, Giampiero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701966/
https://www.ncbi.nlm.nih.gov/pubmed/34948862
http://dx.doi.org/10.3390/ijerph182413253
_version_ 1784621131749130240
author Antonazzo, Ippazio Cosimo
Fornari, Carla
Maumus-Robert, Sandy
Cei, Eleonora
Paoletti, Olga
Conti, Sara
Cortesi, Paolo Angelo
Mantovani, Lorenzo Giovanni
Gini, Rosa
Mazzaglia, Giampiero
author_facet Antonazzo, Ippazio Cosimo
Fornari, Carla
Maumus-Robert, Sandy
Cei, Eleonora
Paoletti, Olga
Conti, Sara
Cortesi, Paolo Angelo
Mantovani, Lorenzo Giovanni
Gini, Rosa
Mazzaglia, Giampiero
author_sort Antonazzo, Ippazio Cosimo
collection PubMed
description Background: In 2020, during the COVID-19 pandemic, Italy implemented two national lockdowns aimed at reducing virus transmission. We assessed whether these lockdowns affected anti-seizure medication (ASM) use and epilepsy-related access to emergency departments (ED) in the general population. Methods: We performed a population-based study using the healthcare administrative database of Tuscany. We defined the weekly time series of prevalence and incidence of ASM, along with the incidence of epilepsy-related ED access from 1 January 2018 to 27 December 2020 in the general population. An interrupted time-series analysis was used to assess the effect of lockdowns on the observed outcomes. Results: Compared to pre-lockdown, we observed a relevant reduction of ASM incidence (0.65; 95% Confidence Intervals: 0.59–0.72) and ED access (0.72; 0.64–0.82), and a slight decrease of ASM prevalence (0.95; 0.94–0.96). During the post-lockdown the ASM incidence reported higher values compared to pre-lockdown, whereas ASM prevalence and ED access remained lower. Results also indicate a lower impact of the second lockdown for both ASM prevalence (0.97; 0.96–0.98) and incidence (0.89; 0.80–0.99). Conclusion: The lockdowns implemented during the COVID-19 outbreaks significantly affected ASM use and epilepsy-related ED access. The potential consequences of these phenomenon are still unknown, although an increased incidence of epilepsy-related symptoms after the first lockdown has been observed. These findings emphasize the need of ensuring continuous care of epileptic patients in stressful conditions such as the COVID-19 pandemic.
format Online
Article
Text
id pubmed-8701966
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87019662021-12-24 Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis Antonazzo, Ippazio Cosimo Fornari, Carla Maumus-Robert, Sandy Cei, Eleonora Paoletti, Olga Conti, Sara Cortesi, Paolo Angelo Mantovani, Lorenzo Giovanni Gini, Rosa Mazzaglia, Giampiero Int J Environ Res Public Health Article Background: In 2020, during the COVID-19 pandemic, Italy implemented two national lockdowns aimed at reducing virus transmission. We assessed whether these lockdowns affected anti-seizure medication (ASM) use and epilepsy-related access to emergency departments (ED) in the general population. Methods: We performed a population-based study using the healthcare administrative database of Tuscany. We defined the weekly time series of prevalence and incidence of ASM, along with the incidence of epilepsy-related ED access from 1 January 2018 to 27 December 2020 in the general population. An interrupted time-series analysis was used to assess the effect of lockdowns on the observed outcomes. Results: Compared to pre-lockdown, we observed a relevant reduction of ASM incidence (0.65; 95% Confidence Intervals: 0.59–0.72) and ED access (0.72; 0.64–0.82), and a slight decrease of ASM prevalence (0.95; 0.94–0.96). During the post-lockdown the ASM incidence reported higher values compared to pre-lockdown, whereas ASM prevalence and ED access remained lower. Results also indicate a lower impact of the second lockdown for both ASM prevalence (0.97; 0.96–0.98) and incidence (0.89; 0.80–0.99). Conclusion: The lockdowns implemented during the COVID-19 outbreaks significantly affected ASM use and epilepsy-related ED access. The potential consequences of these phenomenon are still unknown, although an increased incidence of epilepsy-related symptoms after the first lockdown has been observed. These findings emphasize the need of ensuring continuous care of epileptic patients in stressful conditions such as the COVID-19 pandemic. MDPI 2021-12-16 /pmc/articles/PMC8701966/ /pubmed/34948862 http://dx.doi.org/10.3390/ijerph182413253 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Antonazzo, Ippazio Cosimo
Fornari, Carla
Maumus-Robert, Sandy
Cei, Eleonora
Paoletti, Olga
Conti, Sara
Cortesi, Paolo Angelo
Mantovani, Lorenzo Giovanni
Gini, Rosa
Mazzaglia, Giampiero
Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
title Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
title_full Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
title_fullStr Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
title_full_unstemmed Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
title_short Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
title_sort impact of covid-19 lockdown, during the two waves, on drug use and emergency department access in people with epilepsy: an interrupted time-series analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701966/
https://www.ncbi.nlm.nih.gov/pubmed/34948862
http://dx.doi.org/10.3390/ijerph182413253
work_keys_str_mv AT antonazzoippaziocosimo impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis
AT fornaricarla impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis
AT maumusrobertsandy impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis
AT ceieleonora impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis
AT paolettiolga impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis
AT contisara impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis
AT cortesipaoloangelo impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis
AT mantovanilorenzogiovanni impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis
AT ginirosa impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis
AT mazzagliagiampiero impactofcovid19lockdownduringthetwowavesondruguseandemergencydepartmentaccessinpeoplewithepilepsyaninterruptedtimeseriesanalysis