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Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile

Background: Both obesity and alcohol consumption are strongly associated with dyslipidemia; however, it remains unclear whether their joint effect on lipid profiles is through mediation, interaction, or a combination of the two. Methods: In total, 9849 subjects were selected from the 2009 panel of C...

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Autores principales: Gao, Chaonan, Yu, Wenhao, Zhao, Xiangjuan, Li, Chunxia, Fan, Bingbing, Lv, Jiali, Wei, Mengke, He, Li, Su, Chang, Zhang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701985/
https://www.ncbi.nlm.nih.gov/pubmed/34948819
http://dx.doi.org/10.3390/ijerph182413211
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author Gao, Chaonan
Yu, Wenhao
Zhao, Xiangjuan
Li, Chunxia
Fan, Bingbing
Lv, Jiali
Wei, Mengke
He, Li
Su, Chang
Zhang, Tao
author_facet Gao, Chaonan
Yu, Wenhao
Zhao, Xiangjuan
Li, Chunxia
Fan, Bingbing
Lv, Jiali
Wei, Mengke
He, Li
Su, Chang
Zhang, Tao
author_sort Gao, Chaonan
collection PubMed
description Background: Both obesity and alcohol consumption are strongly associated with dyslipidemia; however, it remains unclear whether their joint effect on lipid profiles is through mediation, interaction, or a combination of the two. Methods: In total, 9849 subjects were selected from the 2009 panel of China Health and Nutrition Survey (CHNS). A four-way decomposition method was used to validate the pathways of drinking and body mass index (BMI) on lipids (total cholesterol, TC; triglyceride, TG; low-density lipoprotein cholesterol, LDL-C; high-density lipoprotein cholesterol, HDL-C; apolipoprotein A, APO-A; and apolipoprotein B, APO-B). Results: According to four-way decomposition, the total effects of drinking on lipids were found to be statistically significant, except for LDL-C. The components due to reference interaction were 0.63, 0.48, 0.60, −0.39, −0.30, and 0.20 for TC, TG, LDL-C, HDL-C, APO-A and APO-B, respectively (p < 0.05 for all). The effect size of pure indirect effect and mediated interaction were 0.001~0.006 (p > 0.05 for all). Further, linear regression models were used to examine the effect of BMI on lipid profiles in drinkers and non-drinkers. The associations of BMI and lipids were higher in all drinkers than in non-drinkers (0.069 versus 0.048 for TC, 0.079 versus 0.059 for TG, 0.057 versus 0.037 for LDL-C, −0.045 versus −0.029 for HDL-C, −0.024 versus −0.011 for APO-A and 0.026 versus 0.019 for APO-B, p interaction <0.05 for all). Conclusions: The joint effect of alcohol consumption and obesity on lipid profiles is through interaction rather than mediation. Alcohol consumption amplifies the harmful effect of BMI on lipid profiles. Greater attention should be paid to lipid health and cardiovascular risk in obese individuals regarding alcohol consumption. For obese individuals, we do not recommend alcohol consumption.
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spelling pubmed-87019852021-12-24 Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile Gao, Chaonan Yu, Wenhao Zhao, Xiangjuan Li, Chunxia Fan, Bingbing Lv, Jiali Wei, Mengke He, Li Su, Chang Zhang, Tao Int J Environ Res Public Health Article Background: Both obesity and alcohol consumption are strongly associated with dyslipidemia; however, it remains unclear whether their joint effect on lipid profiles is through mediation, interaction, or a combination of the two. Methods: In total, 9849 subjects were selected from the 2009 panel of China Health and Nutrition Survey (CHNS). A four-way decomposition method was used to validate the pathways of drinking and body mass index (BMI) on lipids (total cholesterol, TC; triglyceride, TG; low-density lipoprotein cholesterol, LDL-C; high-density lipoprotein cholesterol, HDL-C; apolipoprotein A, APO-A; and apolipoprotein B, APO-B). Results: According to four-way decomposition, the total effects of drinking on lipids were found to be statistically significant, except for LDL-C. The components due to reference interaction were 0.63, 0.48, 0.60, −0.39, −0.30, and 0.20 for TC, TG, LDL-C, HDL-C, APO-A and APO-B, respectively (p < 0.05 for all). The effect size of pure indirect effect and mediated interaction were 0.001~0.006 (p > 0.05 for all). Further, linear regression models were used to examine the effect of BMI on lipid profiles in drinkers and non-drinkers. The associations of BMI and lipids were higher in all drinkers than in non-drinkers (0.069 versus 0.048 for TC, 0.079 versus 0.059 for TG, 0.057 versus 0.037 for LDL-C, −0.045 versus −0.029 for HDL-C, −0.024 versus −0.011 for APO-A and 0.026 versus 0.019 for APO-B, p interaction <0.05 for all). Conclusions: The joint effect of alcohol consumption and obesity on lipid profiles is through interaction rather than mediation. Alcohol consumption amplifies the harmful effect of BMI on lipid profiles. Greater attention should be paid to lipid health and cardiovascular risk in obese individuals regarding alcohol consumption. For obese individuals, we do not recommend alcohol consumption. MDPI 2021-12-15 /pmc/articles/PMC8701985/ /pubmed/34948819 http://dx.doi.org/10.3390/ijerph182413211 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gao, Chaonan
Yu, Wenhao
Zhao, Xiangjuan
Li, Chunxia
Fan, Bingbing
Lv, Jiali
Wei, Mengke
He, Li
Su, Chang
Zhang, Tao
Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile
title Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile
title_full Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile
title_fullStr Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile
title_full_unstemmed Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile
title_short Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile
title_sort four-way decomposition of effect of alcohol consumption and body mass index on lipid profile
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701985/
https://www.ncbi.nlm.nih.gov/pubmed/34948819
http://dx.doi.org/10.3390/ijerph182413211
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