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Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile
Background: Both obesity and alcohol consumption are strongly associated with dyslipidemia; however, it remains unclear whether their joint effect on lipid profiles is through mediation, interaction, or a combination of the two. Methods: In total, 9849 subjects were selected from the 2009 panel of C...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701985/ https://www.ncbi.nlm.nih.gov/pubmed/34948819 http://dx.doi.org/10.3390/ijerph182413211 |
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author | Gao, Chaonan Yu, Wenhao Zhao, Xiangjuan Li, Chunxia Fan, Bingbing Lv, Jiali Wei, Mengke He, Li Su, Chang Zhang, Tao |
author_facet | Gao, Chaonan Yu, Wenhao Zhao, Xiangjuan Li, Chunxia Fan, Bingbing Lv, Jiali Wei, Mengke He, Li Su, Chang Zhang, Tao |
author_sort | Gao, Chaonan |
collection | PubMed |
description | Background: Both obesity and alcohol consumption are strongly associated with dyslipidemia; however, it remains unclear whether their joint effect on lipid profiles is through mediation, interaction, or a combination of the two. Methods: In total, 9849 subjects were selected from the 2009 panel of China Health and Nutrition Survey (CHNS). A four-way decomposition method was used to validate the pathways of drinking and body mass index (BMI) on lipids (total cholesterol, TC; triglyceride, TG; low-density lipoprotein cholesterol, LDL-C; high-density lipoprotein cholesterol, HDL-C; apolipoprotein A, APO-A; and apolipoprotein B, APO-B). Results: According to four-way decomposition, the total effects of drinking on lipids were found to be statistically significant, except for LDL-C. The components due to reference interaction were 0.63, 0.48, 0.60, −0.39, −0.30, and 0.20 for TC, TG, LDL-C, HDL-C, APO-A and APO-B, respectively (p < 0.05 for all). The effect size of pure indirect effect and mediated interaction were 0.001~0.006 (p > 0.05 for all). Further, linear regression models were used to examine the effect of BMI on lipid profiles in drinkers and non-drinkers. The associations of BMI and lipids were higher in all drinkers than in non-drinkers (0.069 versus 0.048 for TC, 0.079 versus 0.059 for TG, 0.057 versus 0.037 for LDL-C, −0.045 versus −0.029 for HDL-C, −0.024 versus −0.011 for APO-A and 0.026 versus 0.019 for APO-B, p interaction <0.05 for all). Conclusions: The joint effect of alcohol consumption and obesity on lipid profiles is through interaction rather than mediation. Alcohol consumption amplifies the harmful effect of BMI on lipid profiles. Greater attention should be paid to lipid health and cardiovascular risk in obese individuals regarding alcohol consumption. For obese individuals, we do not recommend alcohol consumption. |
format | Online Article Text |
id | pubmed-8701985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87019852021-12-24 Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile Gao, Chaonan Yu, Wenhao Zhao, Xiangjuan Li, Chunxia Fan, Bingbing Lv, Jiali Wei, Mengke He, Li Su, Chang Zhang, Tao Int J Environ Res Public Health Article Background: Both obesity and alcohol consumption are strongly associated with dyslipidemia; however, it remains unclear whether their joint effect on lipid profiles is through mediation, interaction, or a combination of the two. Methods: In total, 9849 subjects were selected from the 2009 panel of China Health and Nutrition Survey (CHNS). A four-way decomposition method was used to validate the pathways of drinking and body mass index (BMI) on lipids (total cholesterol, TC; triglyceride, TG; low-density lipoprotein cholesterol, LDL-C; high-density lipoprotein cholesterol, HDL-C; apolipoprotein A, APO-A; and apolipoprotein B, APO-B). Results: According to four-way decomposition, the total effects of drinking on lipids were found to be statistically significant, except for LDL-C. The components due to reference interaction were 0.63, 0.48, 0.60, −0.39, −0.30, and 0.20 for TC, TG, LDL-C, HDL-C, APO-A and APO-B, respectively (p < 0.05 for all). The effect size of pure indirect effect and mediated interaction were 0.001~0.006 (p > 0.05 for all). Further, linear regression models were used to examine the effect of BMI on lipid profiles in drinkers and non-drinkers. The associations of BMI and lipids were higher in all drinkers than in non-drinkers (0.069 versus 0.048 for TC, 0.079 versus 0.059 for TG, 0.057 versus 0.037 for LDL-C, −0.045 versus −0.029 for HDL-C, −0.024 versus −0.011 for APO-A and 0.026 versus 0.019 for APO-B, p interaction <0.05 for all). Conclusions: The joint effect of alcohol consumption and obesity on lipid profiles is through interaction rather than mediation. Alcohol consumption amplifies the harmful effect of BMI on lipid profiles. Greater attention should be paid to lipid health and cardiovascular risk in obese individuals regarding alcohol consumption. For obese individuals, we do not recommend alcohol consumption. MDPI 2021-12-15 /pmc/articles/PMC8701985/ /pubmed/34948819 http://dx.doi.org/10.3390/ijerph182413211 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gao, Chaonan Yu, Wenhao Zhao, Xiangjuan Li, Chunxia Fan, Bingbing Lv, Jiali Wei, Mengke He, Li Su, Chang Zhang, Tao Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile |
title | Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile |
title_full | Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile |
title_fullStr | Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile |
title_full_unstemmed | Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile |
title_short | Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile |
title_sort | four-way decomposition of effect of alcohol consumption and body mass index on lipid profile |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701985/ https://www.ncbi.nlm.nih.gov/pubmed/34948819 http://dx.doi.org/10.3390/ijerph182413211 |
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