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Fipronil and Fipronil Sulfone Distribution in Chicken Feathers and Eggs after Oral and Dermal Exposure

This work aimed to investigate the bio-distribution and the persistence of fipronil and its primary metabolite fipronil sulfone after oral and dermal administration by simulating natural farming conditions. Fipronil and fipronil sulfone detection and quantification were performed in different poultr...

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Autores principales: Corrias, Francesco, Atzei, Alessandro, Taddeo, Riccardo, Arru, Nicola, Casula, Mattia, Salghi, Rachid, Russo, Mariateresa, Angioni, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702044/
https://www.ncbi.nlm.nih.gov/pubmed/34945631
http://dx.doi.org/10.3390/foods10123077
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author Corrias, Francesco
Atzei, Alessandro
Taddeo, Riccardo
Arru, Nicola
Casula, Mattia
Salghi, Rachid
Russo, Mariateresa
Angioni, Alberto
author_facet Corrias, Francesco
Atzei, Alessandro
Taddeo, Riccardo
Arru, Nicola
Casula, Mattia
Salghi, Rachid
Russo, Mariateresa
Angioni, Alberto
author_sort Corrias, Francesco
collection PubMed
description This work aimed to investigate the bio-distribution and the persistence of fipronil and its primary metabolite fipronil sulfone after oral and dermal administration by simulating natural farming conditions. Fipronil and fipronil sulfone detection and quantification were performed in different poultry matrices using an LC-MS/MS method coupled with modified QuEChERS extraction. After oral administration, fipronil was detected in feathers at each sampling time, in eggs for 28 days, and in the internal organs at the end of the experiment. After dermal administration, high levels of fipronil were detected in feathers, accounting for 195.85 ± 8.54 mg/kg, which were reduced by a third after 60 days. No traces of fipronil were detected in the eggs or internal organs. In addition, fipronil sulfone showed remarkable residues in all samples in trial 2. The data obtained confirmed that inappropriate use of unauthorized pesticides can lead to severe contamination of entire poultry farms. The contemporary presence of fipronil sulfone in feathers and eggs associated with the lack of fipronil in eggs suggests recent dermal contamination or past oral contamination. Moreover, simultaneous analysis of hens’ feathers and eggs could represent a new method to improve large-scale monitoring programs and animal welfare, limiting their slaughter.
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spelling pubmed-87020442021-12-24 Fipronil and Fipronil Sulfone Distribution in Chicken Feathers and Eggs after Oral and Dermal Exposure Corrias, Francesco Atzei, Alessandro Taddeo, Riccardo Arru, Nicola Casula, Mattia Salghi, Rachid Russo, Mariateresa Angioni, Alberto Foods Article This work aimed to investigate the bio-distribution and the persistence of fipronil and its primary metabolite fipronil sulfone after oral and dermal administration by simulating natural farming conditions. Fipronil and fipronil sulfone detection and quantification were performed in different poultry matrices using an LC-MS/MS method coupled with modified QuEChERS extraction. After oral administration, fipronil was detected in feathers at each sampling time, in eggs for 28 days, and in the internal organs at the end of the experiment. After dermal administration, high levels of fipronil were detected in feathers, accounting for 195.85 ± 8.54 mg/kg, which were reduced by a third after 60 days. No traces of fipronil were detected in the eggs or internal organs. In addition, fipronil sulfone showed remarkable residues in all samples in trial 2. The data obtained confirmed that inappropriate use of unauthorized pesticides can lead to severe contamination of entire poultry farms. The contemporary presence of fipronil sulfone in feathers and eggs associated with the lack of fipronil in eggs suggests recent dermal contamination or past oral contamination. Moreover, simultaneous analysis of hens’ feathers and eggs could represent a new method to improve large-scale monitoring programs and animal welfare, limiting their slaughter. MDPI 2021-12-10 /pmc/articles/PMC8702044/ /pubmed/34945631 http://dx.doi.org/10.3390/foods10123077 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Corrias, Francesco
Atzei, Alessandro
Taddeo, Riccardo
Arru, Nicola
Casula, Mattia
Salghi, Rachid
Russo, Mariateresa
Angioni, Alberto
Fipronil and Fipronil Sulfone Distribution in Chicken Feathers and Eggs after Oral and Dermal Exposure
title Fipronil and Fipronil Sulfone Distribution in Chicken Feathers and Eggs after Oral and Dermal Exposure
title_full Fipronil and Fipronil Sulfone Distribution in Chicken Feathers and Eggs after Oral and Dermal Exposure
title_fullStr Fipronil and Fipronil Sulfone Distribution in Chicken Feathers and Eggs after Oral and Dermal Exposure
title_full_unstemmed Fipronil and Fipronil Sulfone Distribution in Chicken Feathers and Eggs after Oral and Dermal Exposure
title_short Fipronil and Fipronil Sulfone Distribution in Chicken Feathers and Eggs after Oral and Dermal Exposure
title_sort fipronil and fipronil sulfone distribution in chicken feathers and eggs after oral and dermal exposure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702044/
https://www.ncbi.nlm.nih.gov/pubmed/34945631
http://dx.doi.org/10.3390/foods10123077
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