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Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age
Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optim...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702147/ https://www.ncbi.nlm.nih.gov/pubmed/34948669 http://dx.doi.org/10.3390/ijerph182413060 |
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author | Hu, Yichun Li, Siran Wang, Jun Zheng, Deqiang Zhang, Huidi Yu, Wei Zhu, Lijia Liu, Zhen Yang, Xiaoguang Yang, Lichen |
author_facet | Hu, Yichun Li, Siran Wang, Jun Zheng, Deqiang Zhang, Huidi Yu, Wei Zhu, Lijia Liu, Zhen Yang, Xiaoguang Yang, Lichen |
author_sort | Hu, Yichun |
collection | PubMed |
description | Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. Methods: Serum samples were selected from the biological samples’ bank of the Chinese Chronic Diseases and Nutrition Survey (CCDNS) 2015. The serum 25(OH)D concentration was determined by liquid chromatography tandem mass spectrometry and the serum PTH was determined by electronic chemiluminescence. Simple linear and partial correlation analysis, locally weighted regression smooth scatterplot (LOESS), nonlinear least squares estimation (NLS), and segmented regression (SR) were utilized to estimate the relationship of 25(OH)D and PTH, and to determine the threshold of 25(OH)D. Results: A total of 1568 serum samples of 25(OH)D concentration and PTH concentration were analyzed. A significant inverse relationship between 25(OH)D and PTH concentration was observed below 15.25 (14.22–16.28) ng/mL, and PTH decreased slowly with the increase of 25(OH)D above 16.75 (15.43–18.06) ng/mL after adjusting by age, latitude, city type, season, corrected calcium, and phosphorus. A very short plateau of PTH was found at 15.25 ng/mL and 16.75 ng/mL in terms of 25(OH)D according to LOESS, NLS, and SR. Conclusions: The serum 25(OH)D was negatively correlated with the serum PTH. The threshold of VitD sufficiency was found in the range of 14.22–18.06 ng/mL in terms of serum 25(OH)D concentration for Chinese childbearing women aged 18–44 years old. |
format | Online Article Text |
id | pubmed-8702147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87021472021-12-24 Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age Hu, Yichun Li, Siran Wang, Jun Zheng, Deqiang Zhang, Huidi Yu, Wei Zhu, Lijia Liu, Zhen Yang, Xiaoguang Yang, Lichen Int J Environ Res Public Health Article Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. Methods: Serum samples were selected from the biological samples’ bank of the Chinese Chronic Diseases and Nutrition Survey (CCDNS) 2015. The serum 25(OH)D concentration was determined by liquid chromatography tandem mass spectrometry and the serum PTH was determined by electronic chemiluminescence. Simple linear and partial correlation analysis, locally weighted regression smooth scatterplot (LOESS), nonlinear least squares estimation (NLS), and segmented regression (SR) were utilized to estimate the relationship of 25(OH)D and PTH, and to determine the threshold of 25(OH)D. Results: A total of 1568 serum samples of 25(OH)D concentration and PTH concentration were analyzed. A significant inverse relationship between 25(OH)D and PTH concentration was observed below 15.25 (14.22–16.28) ng/mL, and PTH decreased slowly with the increase of 25(OH)D above 16.75 (15.43–18.06) ng/mL after adjusting by age, latitude, city type, season, corrected calcium, and phosphorus. A very short plateau of PTH was found at 15.25 ng/mL and 16.75 ng/mL in terms of 25(OH)D according to LOESS, NLS, and SR. Conclusions: The serum 25(OH)D was negatively correlated with the serum PTH. The threshold of VitD sufficiency was found in the range of 14.22–18.06 ng/mL in terms of serum 25(OH)D concentration for Chinese childbearing women aged 18–44 years old. MDPI 2021-12-10 /pmc/articles/PMC8702147/ /pubmed/34948669 http://dx.doi.org/10.3390/ijerph182413060 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hu, Yichun Li, Siran Wang, Jun Zheng, Deqiang Zhang, Huidi Yu, Wei Zhu, Lijia Liu, Zhen Yang, Xiaoguang Yang, Lichen Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age |
title | Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age |
title_full | Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age |
title_fullStr | Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age |
title_full_unstemmed | Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age |
title_short | Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age |
title_sort | threshold for relationship between vitamin d and parathyroid hormone in chinese women of childbearing age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702147/ https://www.ncbi.nlm.nih.gov/pubmed/34948669 http://dx.doi.org/10.3390/ijerph182413060 |
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