Cargando…
Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
Aging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes in order to maintain homeostasis; they also influence the function of endothelial cells, smooth muscle cells, and...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702158/ https://www.ncbi.nlm.nih.gov/pubmed/34948558 http://dx.doi.org/10.3390/ijerph182412949 |
_version_ | 1784621179648081920 |
---|---|
author | Silva, Bruna Spolador de Alencar Uzeloto, Juliana Souza Lira, Fábio Santos Pereira, Telmo Coelho-E-Silva, Manuel J. Caseiro, Armando |
author_facet | Silva, Bruna Spolador de Alencar Uzeloto, Juliana Souza Lira, Fábio Santos Pereira, Telmo Coelho-E-Silva, Manuel J. Caseiro, Armando |
author_sort | Silva, Bruna Spolador de Alencar |
collection | PubMed |
description | Aging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes in order to maintain homeostasis; they also influence the function of endothelial cells, smooth muscle cells, and immune cells in the vessel wall. A clock misalignment could favor vascular damage and indirectly also affect skeletal muscle function. In this review, we focus on the dysregulation of circadian rhythm due to aging and its relationship with skeletal muscle changes and vascular health as possible risk factors for the development of sarcopenia, as well as the role of physical exercise as a potential modulator of these processes. |
format | Online Article Text |
id | pubmed-8702158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87021582021-12-24 Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging Silva, Bruna Spolador de Alencar Uzeloto, Juliana Souza Lira, Fábio Santos Pereira, Telmo Coelho-E-Silva, Manuel J. Caseiro, Armando Int J Environ Res Public Health Review Aging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes in order to maintain homeostasis; they also influence the function of endothelial cells, smooth muscle cells, and immune cells in the vessel wall. A clock misalignment could favor vascular damage and indirectly also affect skeletal muscle function. In this review, we focus on the dysregulation of circadian rhythm due to aging and its relationship with skeletal muscle changes and vascular health as possible risk factors for the development of sarcopenia, as well as the role of physical exercise as a potential modulator of these processes. MDPI 2021-12-08 /pmc/articles/PMC8702158/ /pubmed/34948558 http://dx.doi.org/10.3390/ijerph182412949 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Silva, Bruna Spolador de Alencar Uzeloto, Juliana Souza Lira, Fábio Santos Pereira, Telmo Coelho-E-Silva, Manuel J. Caseiro, Armando Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging |
title | Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging |
title_full | Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging |
title_fullStr | Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging |
title_full_unstemmed | Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging |
title_short | Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging |
title_sort | exercise as a peripheral circadian clock resynchronizer in vascular and skeletal muscle aging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702158/ https://www.ncbi.nlm.nih.gov/pubmed/34948558 http://dx.doi.org/10.3390/ijerph182412949 |
work_keys_str_mv | AT silvabrunaspoladordealencar exerciseasaperipheralcircadianclockresynchronizerinvascularandskeletalmuscleaging AT uzelotojulianasouza exerciseasaperipheralcircadianclockresynchronizerinvascularandskeletalmuscleaging AT lirafabiosantos exerciseasaperipheralcircadianclockresynchronizerinvascularandskeletalmuscleaging AT pereiratelmo exerciseasaperipheralcircadianclockresynchronizerinvascularandskeletalmuscleaging AT coelhoesilvamanuelj exerciseasaperipheralcircadianclockresynchronizerinvascularandskeletalmuscleaging AT caseiroarmando exerciseasaperipheralcircadianclockresynchronizerinvascularandskeletalmuscleaging |