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Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China

Gut microbiota dysbiosis is closely associated with intestinal carcinogenesis, but the oral microbiota of patients with esophageal squamous cell carcinoma who live in high-risk regions in China has not been fully characterized. In the current study, oral microbial diversity was investigated in 33 pa...

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Autores principales: Li, Hezi, Luo, Zhilin, Zhang, Hong, Huang, Nali, Li, Dong, Luo, Chengwen, Wang, Tianhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702330/
https://www.ncbi.nlm.nih.gov/pubmed/34957299
http://dx.doi.org/10.1155/2021/2259093
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author Li, Hezi
Luo, Zhilin
Zhang, Hong
Huang, Nali
Li, Dong
Luo, Chengwen
Wang, Tianhu
author_facet Li, Hezi
Luo, Zhilin
Zhang, Hong
Huang, Nali
Li, Dong
Luo, Chengwen
Wang, Tianhu
author_sort Li, Hezi
collection PubMed
description Gut microbiota dysbiosis is closely associated with intestinal carcinogenesis, but the oral microbiota of patients with esophageal squamous cell carcinoma who live in high-risk regions in China has not been fully characterized. In the current study, oral microbial diversity was investigated in 33 patients with esophageal squamous cell carcinoma and 35 healthy controls in Chongqing, China, by sequencing 16S rRNA of V3-V4 gene regions. There were statistically significant differences in oral microbiota between esophageal squamous cell carcinoma patients and controls as determined via unweighted pair-group analysis with arithmetic means. At the phylum level, in esophageal squamous cell carcinoma patients, there were comparatively greater amounts of Firmicutes (34.0% vs. 31.1%) and Bacteroidetes (25.3% vs. 24.9%) and lower amounts of Proteobacteria (17.0% vs. 20.1%). At the genus level, esophageal squamous cell carcinoma patients exhibited comparatively greater amounts of Streptococcus (17.3% vs. 14.5%) and Prevotella_7 (8.6% vs. 8.5%) and lower amounts of Neisseria (8.1% vs. 10.7%). Using a linear discriminant analysis effect size method, Planctomycetes and Verrucomicrobia were identified in the esophageal squamous cell carcinoma group. 10 genera were higher abundances identified in the healthy control group, and different 10 genera were identified in the esophageal squamous cell carcinoma group. In the present study, there were significant differences in oral microbial compositions of esophageal squamous cell carcinoma patients and healthy controls. Further longitudinal and mechanistic studies are needed to further characterize relationships between oral microbiota and esophageal squamous cell carcinoma.
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spelling pubmed-87023302021-12-24 Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China Li, Hezi Luo, Zhilin Zhang, Hong Huang, Nali Li, Dong Luo, Chengwen Wang, Tianhu Biomed Res Int Research Article Gut microbiota dysbiosis is closely associated with intestinal carcinogenesis, but the oral microbiota of patients with esophageal squamous cell carcinoma who live in high-risk regions in China has not been fully characterized. In the current study, oral microbial diversity was investigated in 33 patients with esophageal squamous cell carcinoma and 35 healthy controls in Chongqing, China, by sequencing 16S rRNA of V3-V4 gene regions. There were statistically significant differences in oral microbiota between esophageal squamous cell carcinoma patients and controls as determined via unweighted pair-group analysis with arithmetic means. At the phylum level, in esophageal squamous cell carcinoma patients, there were comparatively greater amounts of Firmicutes (34.0% vs. 31.1%) and Bacteroidetes (25.3% vs. 24.9%) and lower amounts of Proteobacteria (17.0% vs. 20.1%). At the genus level, esophageal squamous cell carcinoma patients exhibited comparatively greater amounts of Streptococcus (17.3% vs. 14.5%) and Prevotella_7 (8.6% vs. 8.5%) and lower amounts of Neisseria (8.1% vs. 10.7%). Using a linear discriminant analysis effect size method, Planctomycetes and Verrucomicrobia were identified in the esophageal squamous cell carcinoma group. 10 genera were higher abundances identified in the healthy control group, and different 10 genera were identified in the esophageal squamous cell carcinoma group. In the present study, there were significant differences in oral microbial compositions of esophageal squamous cell carcinoma patients and healthy controls. Further longitudinal and mechanistic studies are needed to further characterize relationships between oral microbiota and esophageal squamous cell carcinoma. Hindawi 2021-12-16 /pmc/articles/PMC8702330/ /pubmed/34957299 http://dx.doi.org/10.1155/2021/2259093 Text en Copyright © 2021 Hezi Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Hezi
Luo, Zhilin
Zhang, Hong
Huang, Nali
Li, Dong
Luo, Chengwen
Wang, Tianhu
Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China
title Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China
title_full Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China
title_fullStr Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China
title_full_unstemmed Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China
title_short Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China
title_sort characteristics of oral microbiota in patients with esophageal cancer in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702330/
https://www.ncbi.nlm.nih.gov/pubmed/34957299
http://dx.doi.org/10.1155/2021/2259093
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