Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?

Langerhans cell histiocytosis lesions are characterized by CD1a+ myeloid lineage LCH cells and an inflammatory infiltrate of cytokines and immune cells, including T cells. T cells that recognize CD1a may be implicated in the pathology of many disease states including cancer and autoimmunity but have...

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Detalles Bibliográficos
Autores principales: Mitchell, Jenée, Kannourakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702800/
https://www.ncbi.nlm.nih.gov/pubmed/34956202
http://dx.doi.org/10.3389/fimmu.2021.773598
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author Mitchell, Jenée
Kannourakis, George
author_facet Mitchell, Jenée
Kannourakis, George
author_sort Mitchell, Jenée
collection PubMed
description Langerhans cell histiocytosis lesions are characterized by CD1a+ myeloid lineage LCH cells and an inflammatory infiltrate of cytokines and immune cells, including T cells. T cells that recognize CD1a may be implicated in the pathology of many disease states including cancer and autoimmunity but have not been studied in the context of LCH despite the expression of CD1a by LCH cells. In this perspective article, we discuss the expression of CD1a by LCH cells, and we explore the potential for T cells that recognize CD1a to be involved in LCH pathogenesis.
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spelling pubmed-87028002021-12-25 Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis? Mitchell, Jenée Kannourakis, George Front Immunol Immunology Langerhans cell histiocytosis lesions are characterized by CD1a+ myeloid lineage LCH cells and an inflammatory infiltrate of cytokines and immune cells, including T cells. T cells that recognize CD1a may be implicated in the pathology of many disease states including cancer and autoimmunity but have not been studied in the context of LCH despite the expression of CD1a by LCH cells. In this perspective article, we discuss the expression of CD1a by LCH cells, and we explore the potential for T cells that recognize CD1a to be involved in LCH pathogenesis. Frontiers Media S.A. 2021-12-10 /pmc/articles/PMC8702800/ /pubmed/34956202 http://dx.doi.org/10.3389/fimmu.2021.773598 Text en Copyright © 2021 Mitchell and Kannourakis https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Mitchell, Jenée
Kannourakis, George
Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?
title Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?
title_full Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?
title_fullStr Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?
title_full_unstemmed Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?
title_short Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?
title_sort does cd1a expression influence t cell function in patients with langerhans cell histiocytosis?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702800/
https://www.ncbi.nlm.nih.gov/pubmed/34956202
http://dx.doi.org/10.3389/fimmu.2021.773598
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