Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

Background: Intestinal damage caused by intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) can lead to the ectopic gut microbiota, which can contribute to liver injury via portal veins. Therefore, it is speculated that gut microbiota disorder caused by IAH/ACS may result in...

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Autores principales: Zhao, Zeyu, Guo, Zhengchang, Yin, Zhengliang, Qiu, Yue, Zhou, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703017/
https://www.ncbi.nlm.nih.gov/pubmed/34955896
http://dx.doi.org/10.3389/fphys.2021.790182
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author Zhao, Zeyu
Guo, Zhengchang
Yin, Zhengliang
Qiu, Yue
Zhou, Bo
author_facet Zhao, Zeyu
Guo, Zhengchang
Yin, Zhengliang
Qiu, Yue
Zhou, Bo
author_sort Zhao, Zeyu
collection PubMed
description Background: Intestinal damage caused by intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) can lead to the ectopic gut microbiota, which can contribute to liver injury via portal veins. Therefore, it is speculated that gut microbiota disorder caused by IAH/ACS may result in liver injury. The relationship between gut microbiota and IAH/ACS-related liver injury was investigated in this study. Methods: A model of IAH was established in rats, and 16S rRNA sequencing was analyzed for gut microbiota in the feces of rats. The elimination of gut microbiota was completed by antibiotics gavage, and fecal microbiota transplantation (FMT) was used to change the composition of gut microbiota in rats. Results: In addition to the traditional cause of liver blood vessel compression, liver injury caused by IAH was also associated with gut microbiota dysbiosis. Gut microbiota clearance can relieve liver injury caused by IAH, while FMT from IAH-intervened rats can aggravate IAH-related liver injury. Conclusion: The gut microbiota was one of the most important factors contributing to the IAH-related liver injury, and the JNK/p38 signaling pathway was activated in this process.
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spelling pubmed-87030172021-12-25 Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension Zhao, Zeyu Guo, Zhengchang Yin, Zhengliang Qiu, Yue Zhou, Bo Front Physiol Physiology Background: Intestinal damage caused by intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) can lead to the ectopic gut microbiota, which can contribute to liver injury via portal veins. Therefore, it is speculated that gut microbiota disorder caused by IAH/ACS may result in liver injury. The relationship between gut microbiota and IAH/ACS-related liver injury was investigated in this study. Methods: A model of IAH was established in rats, and 16S rRNA sequencing was analyzed for gut microbiota in the feces of rats. The elimination of gut microbiota was completed by antibiotics gavage, and fecal microbiota transplantation (FMT) was used to change the composition of gut microbiota in rats. Results: In addition to the traditional cause of liver blood vessel compression, liver injury caused by IAH was also associated with gut microbiota dysbiosis. Gut microbiota clearance can relieve liver injury caused by IAH, while FMT from IAH-intervened rats can aggravate IAH-related liver injury. Conclusion: The gut microbiota was one of the most important factors contributing to the IAH-related liver injury, and the JNK/p38 signaling pathway was activated in this process. Frontiers Media S.A. 2021-12-10 /pmc/articles/PMC8703017/ /pubmed/34955896 http://dx.doi.org/10.3389/fphys.2021.790182 Text en Copyright © 2021 Zhao, Guo, Yin, Qiu and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhao, Zeyu
Guo, Zhengchang
Yin, Zhengliang
Qiu, Yue
Zhou, Bo
Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension
title Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension
title_full Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension
title_fullStr Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension
title_full_unstemmed Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension
title_short Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension
title_sort gut microbiota was involved in the process of liver injury during intra-abdominal hypertension
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703017/
https://www.ncbi.nlm.nih.gov/pubmed/34955896
http://dx.doi.org/10.3389/fphys.2021.790182
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AT yinzhengliang gutmicrobiotawasinvolvedintheprocessofliverinjuryduringintraabdominalhypertension
AT qiuyue gutmicrobiotawasinvolvedintheprocessofliverinjuryduringintraabdominalhypertension
AT zhoubo gutmicrobiotawasinvolvedintheprocessofliverinjuryduringintraabdominalhypertension

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