Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying

During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis. The aqueous drug formulation subsequently spreads over the inner vial wall, while a cold gas flow is used for cooling and freezing the product....

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Detalles Bibliográficos
Autores principales: Nuytten, Gust, Revatta, Susan Ríos, Van Bockstal, Pieter-Jan, Kumar, Ashish, Lammens, Joris, Leys, Laurens, Vanbillemont, Brecht, Corver, Jos, Vervaet, Chris, De Beer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703267/
https://www.ncbi.nlm.nih.gov/pubmed/34959357
http://dx.doi.org/10.3390/pharmaceutics13122076

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