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Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study

New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amou...

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Autores principales: Peptu, Cătălina Anișoara, Băcăiță, Elena Simona, Savin (Logigan), Corina-Lenuta, Luțcanu, Marian, Agop, Maricel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703298/
https://www.ncbi.nlm.nih.gov/pubmed/34961013
http://dx.doi.org/10.3390/polym13244461
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author Peptu, Cătălina Anișoara
Băcăiță, Elena Simona
Savin (Logigan), Corina-Lenuta
Luțcanu, Marian
Agop, Maricel
author_facet Peptu, Cătălina Anișoara
Băcăiță, Elena Simona
Savin (Logigan), Corina-Lenuta
Luțcanu, Marian
Agop, Maricel
author_sort Peptu, Cătălina Anișoara
collection PubMed
description New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amounts of water). The characterization of their structural, morphological, swelling capacity, loading/release and drug efficiency traits proved that these new hydrogels are promising materials for controlled drug delivery systems. Further, a new theoretical model, in the framework of Scale Relativity Theory, was built with to offer insights on the release process at the microscopic level and to simplify the analysis of the release process.
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spelling pubmed-87032982021-12-25 Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study Peptu, Cătălina Anișoara Băcăiță, Elena Simona Savin (Logigan), Corina-Lenuta Luțcanu, Marian Agop, Maricel Polymers (Basel) Article New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amounts of water). The characterization of their structural, morphological, swelling capacity, loading/release and drug efficiency traits proved that these new hydrogels are promising materials for controlled drug delivery systems. Further, a new theoretical model, in the framework of Scale Relativity Theory, was built with to offer insights on the release process at the microscopic level and to simplify the analysis of the release process. MDPI 2021-12-20 /pmc/articles/PMC8703298/ /pubmed/34961013 http://dx.doi.org/10.3390/polym13244461 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peptu, Cătălina Anișoara
Băcăiță, Elena Simona
Savin (Logigan), Corina-Lenuta
Luțcanu, Marian
Agop, Maricel
Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study
title Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study
title_full Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study
title_fullStr Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study
title_full_unstemmed Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study
title_short Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study
title_sort hydrogels based on alginates and carboxymethyl cellulose with modulated drug release—an experimental and theoretical study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703298/
https://www.ncbi.nlm.nih.gov/pubmed/34961013
http://dx.doi.org/10.3390/polym13244461
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