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Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study
New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amou...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703298/ https://www.ncbi.nlm.nih.gov/pubmed/34961013 http://dx.doi.org/10.3390/polym13244461 |
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author | Peptu, Cătălina Anișoara Băcăiță, Elena Simona Savin (Logigan), Corina-Lenuta Luțcanu, Marian Agop, Maricel |
author_facet | Peptu, Cătălina Anișoara Băcăiță, Elena Simona Savin (Logigan), Corina-Lenuta Luțcanu, Marian Agop, Maricel |
author_sort | Peptu, Cătălina Anișoara |
collection | PubMed |
description | New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amounts of water). The characterization of their structural, morphological, swelling capacity, loading/release and drug efficiency traits proved that these new hydrogels are promising materials for controlled drug delivery systems. Further, a new theoretical model, in the framework of Scale Relativity Theory, was built with to offer insights on the release process at the microscopic level and to simplify the analysis of the release process. |
format | Online Article Text |
id | pubmed-8703298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87032982021-12-25 Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study Peptu, Cătălina Anișoara Băcăiță, Elena Simona Savin (Logigan), Corina-Lenuta Luțcanu, Marian Agop, Maricel Polymers (Basel) Article New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amounts of water). The characterization of their structural, morphological, swelling capacity, loading/release and drug efficiency traits proved that these new hydrogels are promising materials for controlled drug delivery systems. Further, a new theoretical model, in the framework of Scale Relativity Theory, was built with to offer insights on the release process at the microscopic level and to simplify the analysis of the release process. MDPI 2021-12-20 /pmc/articles/PMC8703298/ /pubmed/34961013 http://dx.doi.org/10.3390/polym13244461 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Peptu, Cătălina Anișoara Băcăiță, Elena Simona Savin (Logigan), Corina-Lenuta Luțcanu, Marian Agop, Maricel Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study |
title | Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study |
title_full | Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study |
title_fullStr | Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study |
title_full_unstemmed | Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study |
title_short | Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study |
title_sort | hydrogels based on alginates and carboxymethyl cellulose with modulated drug release—an experimental and theoretical study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703298/ https://www.ncbi.nlm.nih.gov/pubmed/34961013 http://dx.doi.org/10.3390/polym13244461 |
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