Inositol Phosphates and Retroviral Assembly: A Cellular Perspective

Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been made in retroviral research. In this review, th...

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Detalles Bibliográficos
Autores principales: Ricaña, Clifton L., Dick, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703376/
https://www.ncbi.nlm.nih.gov/pubmed/34960784
http://dx.doi.org/10.3390/v13122516
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author Ricaña, Clifton L.
Dick, Robert A.
author_facet Ricaña, Clifton L.
Dick, Robert A.
author_sort Ricaña, Clifton L.
collection PubMed
description Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been made in retroviral research. In this review, the enzymatic pathways to synthesize and metabolize inositol phosphates (IPs) relevant to retroviral assembly are discussed. The functions of these enzymes and IPs are outlined in the context of the cellular biology important for retroviruses. Lastly, the recent advances in understanding the role of IPs in retroviral biology are surveyed.
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spelling pubmed-87033762021-12-25 Inositol Phosphates and Retroviral Assembly: A Cellular Perspective Ricaña, Clifton L. Dick, Robert A. Viruses Review Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been made in retroviral research. In this review, the enzymatic pathways to synthesize and metabolize inositol phosphates (IPs) relevant to retroviral assembly are discussed. The functions of these enzymes and IPs are outlined in the context of the cellular biology important for retroviruses. Lastly, the recent advances in understanding the role of IPs in retroviral biology are surveyed. MDPI 2021-12-15 /pmc/articles/PMC8703376/ /pubmed/34960784 http://dx.doi.org/10.3390/v13122516 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ricaña, Clifton L.
Dick, Robert A.
Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
title Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
title_full Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
title_fullStr Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
title_full_unstemmed Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
title_short Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
title_sort inositol phosphates and retroviral assembly: a cellular perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703376/
https://www.ncbi.nlm.nih.gov/pubmed/34960784
http://dx.doi.org/10.3390/v13122516
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