Cargando…

Humanization, Radiolabeling and Biodistribution Studies of an IgG(1)-Type Antibody Targeting Uncomplexed PSA for Theranostic Applications

Metastatic castration-resistant prostate cancer is today incurable. Conventional imaging methods have limited detection, affecting their ability to give an accurate outcome prognosis, and current therapies for metastatic prostate cancer are insufficient. This inevitably leads to patients relapsing w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Strand, Joanna, Sjöström, Kjell, Lamminmaki, Urpo J., Vilhelmsson Timmermand, Oskar, Strand, Sven-Erik, Tran, Thuy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703390/ https://www.ncbi.nlm.nih.gov/pubmed/34959652 http://dx.doi.org/10.3390/ph14121251

Ejemplares similares

Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a (111)In-radiolabelled monoclonal antibody, 11B6
por: Timmermand, Oskar Vilhelmsson, et al.
Publicado: (2014)

Small-scale dosimetry for alpha particle (241)Am source cell irradiation and estimation of γ-H2AX foci distribution in prostate cancer cell line PC3
por: Mellhammar, Emma, et al.
Publicado: (2022)

A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen
por: Vilhelmsson Timmermand, Oskar, et al.
Publicado: (2021)

Preclinical efficacy of hK2 targeted [(177)Lu]hu11B6 for prostate cancer theranostics
por: Timmermand, Oskar Vilhelmsson, et al.
Publicado: (2019)

PRC1 uncomplexed
por: Schouten, Sanne, et al.
Publicado: (2022)

Hematological Toxicity in Mice after High Activity Injections of (177)Lu-PSMA-617
por: Kristiansson, Amanda, et al.
Publicado: (2022)

Kidney Protection with the Radical Scavenger α(1)-Microglobulin (A1M) during Peptide Receptor Radionuclide and Radioligand Therapy
por: Kristiansson, Amanda, et al.
Publicado: (2021)

Radioimmunotherapy of prostate cancer targeting human kallikrein-related peptidase 2
por: Vilhelmsson Timmermand, O., et al.
Publicado: (2016)

(177)Lu-PSMA-617 Therapy in Mice, with or without the Antioxidant α(1)-Microglobulin (A1M), Including Kidney Damage Assessment Using (99m)Tc-MAG3 Imaging
por: Kristiansson, Amanda, et al.
Publicado: (2021)

Complement Receptors 1 and 2 in Murine Antibody Responses to IgM-Complexed and Uncomplexed Sheep Erythrocytes
por: Rutemark, Christian, et al.
Publicado: (2012)

Radiolabeling of Cramoll 1,4: Evaluation of the Biodistribution
por: Ferreira de Carvalho Patricio, Beatriz, et al.
Publicado: (2011)

Radiolabelling of Antigen and Liposomes for Vaccine Biodistribution Studies
por: Henriksen-Lacey, Malou, et al.
Publicado: (2010)

Radiolabeled theranostics: magnetic and gold nanoparticles
por: Same, Saeideh, et al.
Publicado: (2016)

Radiolabelled Aptamers for Theranostic Treatment of Cancer
por: Khalid, Umair, et al.
Publicado: (2018)

Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility
por: Golan, Gali, et al.
Publicado: (2005)

Image Guided Biodistribution and Pharmacokinetic Studies of Theranostics
por: Ding, Hong, et al.
Publicado: (2012)

Radiolabelled polymeric IgA: from biodistribution to a new molecular imaging tool in colorectal cancer lung metastases
por: Carpenet, Helene, et al.
Publicado: (2017)

The effect of circulating antigen and radiolabel stability on the biodistribution of an indium labelled antibody.
por: Davidson, B. R., et al.
Publicado: (1991)

Biodistribution of a Radiolabeled Antibody in Mice as an Approach to Evaluating Antibody Pharmacokinetics
por: Allen, Kevin J. H., et al.
Publicado: (2018)

TrisOxine abiotic siderophores for technetium complexation: radiolabeling and biodistribution studies
por: Leenhardt, Julien, et al.
Publicado: (2023)

Radiolabeled nanobodies as theranostic tools in targeted radionuclide therapy of cancer
por: D’Huyvetter, Matthias, et al.
Publicado: (2014)

Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics
por: Gilpin, Ian Moore F., et al.
Publicado: (2021)

Biodistribution of (68/67)Ga-Radiolabeled Sphingolipid Nanoemulsions by PET and SPECT Imaging
por: Díez-Villares, Sandra, et al.
Publicado: (2021)

Production, purification, and radiolabeling of the (203)Pb/(212)Pb theranostic pair
por: McNeil, Brooke L., et al.
Publicado: (2021)

Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats
por: Priyadarshani, Anjali, et al.
Publicado: (2010)

Physiologically Based Pharmacokinetic (PBPK) Model for Biodistribution of Radiolabeled Peptides in Patients with Neuroendocrine Tumours
por: Gospavic, Radovan, et al.
Publicado: (2016)

(124)I Radiolabeling of a Au(III)‐NHC Complex for In Vivo Biodistribution Studies
por: Guarra, Federica, et al.
Publicado: (2020)

Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM
por: Sharma, Sai Kiran, et al.
Publicado: (2022)

A 15-min non-competitive homogeneous assay for microcystin and nodularin based on time-resolved Förster resonance energy transfer (TR-FRET)
por: Akter, Sultana, et al.
Publicado: (2021)

Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics
por: Velikyan, Irina, et al.
Publicado: (2020)

Covalent core-radiolabeling of polymeric micelles with (125)I/(211)At for theranostic radiotherapy
por: Sporer, Emanuel, et al.
Publicado: (2022)

Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies
por: Hrynchak, Ivanna, et al.
Publicado: (2021)

Immune Checkpoint Inhibitor-Mediated Cancer Theranostics with Radiolabeled Anti-Granzyme B Peptide
por: de Aguiar Ferreira, Carolina, et al.
Publicado: (2022)

Radiolabeled albumin through S(N)Ar of cysteines as a potential pretargeting theranostic agent
por: Fischer, Niklas H., et al.
Publicado: (2022)

In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope
por: Collingridge, D R, et al.
Publicado: (2003)

Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice
por: Vegt, Erik, et al.
Publicado: (2010)

Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
por: Faruqu, Farid N., et al.
Publicado: (2019)

Organ Biodistribution of Radiolabelled γδ T Cells Following Liposomal Alendronate Administration in Different Mouse Tumour Models
por: Wang, Julie T-W., et al.
Publicado: (2020)

Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice
por: Mamai, Maria, et al.
Publicado: (2021)

Biodistribution of neutralizing monoclonal antibodies IgG1 b12 and LALA in mucosal and lymphatic tissues of rhesus macaques
por: Hessell, AJ, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_28mf12b7m0fd68bnon4pqj4upm