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Ion Channels and Transporters in Muscle Cell Differentiation

Investigations on ion channels in muscle tissues have mainly focused on physiological muscle function and related disorders, but emerging evidence supports a critical role of ion channels and transporters in developmental processes, such as controlling the myogenic commitment of stem cells. In this...

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Detalles Bibliográficos
Autores principales: Chen, Lingye, Hassani Nia, Fatemeh, Stauber, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703453/
https://www.ncbi.nlm.nih.gov/pubmed/34948411
http://dx.doi.org/10.3390/ijms222413615
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author Chen, Lingye
Hassani Nia, Fatemeh
Stauber, Tobias
author_facet Chen, Lingye
Hassani Nia, Fatemeh
Stauber, Tobias
author_sort Chen, Lingye
collection PubMed
description Investigations on ion channels in muscle tissues have mainly focused on physiological muscle function and related disorders, but emerging evidence supports a critical role of ion channels and transporters in developmental processes, such as controlling the myogenic commitment of stem cells. In this review, we provide an overview of ion channels and transporters that influence skeletal muscle myoblast differentiation, cardiac differentiation from pluripotent stem cells, as well as vascular smooth muscle cell differentiation. We highlight examples of model organisms or patients with mutations in ion channels. Furthermore, a potential underlying molecular mechanism involving hyperpolarization of the resting membrane potential and a series of calcium signaling is discussed.
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spelling pubmed-87034532021-12-25 Ion Channels and Transporters in Muscle Cell Differentiation Chen, Lingye Hassani Nia, Fatemeh Stauber, Tobias Int J Mol Sci Review Investigations on ion channels in muscle tissues have mainly focused on physiological muscle function and related disorders, but emerging evidence supports a critical role of ion channels and transporters in developmental processes, such as controlling the myogenic commitment of stem cells. In this review, we provide an overview of ion channels and transporters that influence skeletal muscle myoblast differentiation, cardiac differentiation from pluripotent stem cells, as well as vascular smooth muscle cell differentiation. We highlight examples of model organisms or patients with mutations in ion channels. Furthermore, a potential underlying molecular mechanism involving hyperpolarization of the resting membrane potential and a series of calcium signaling is discussed. MDPI 2021-12-19 /pmc/articles/PMC8703453/ /pubmed/34948411 http://dx.doi.org/10.3390/ijms222413615 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Lingye
Hassani Nia, Fatemeh
Stauber, Tobias
Ion Channels and Transporters in Muscle Cell Differentiation
title Ion Channels and Transporters in Muscle Cell Differentiation
title_full Ion Channels and Transporters in Muscle Cell Differentiation
title_fullStr Ion Channels and Transporters in Muscle Cell Differentiation
title_full_unstemmed Ion Channels and Transporters in Muscle Cell Differentiation
title_short Ion Channels and Transporters in Muscle Cell Differentiation
title_sort ion channels and transporters in muscle cell differentiation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703453/
https://www.ncbi.nlm.nih.gov/pubmed/34948411
http://dx.doi.org/10.3390/ijms222413615
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