Cargando…
Ion Channels and Transporters in Muscle Cell Differentiation
Investigations on ion channels in muscle tissues have mainly focused on physiological muscle function and related disorders, but emerging evidence supports a critical role of ion channels and transporters in developmental processes, such as controlling the myogenic commitment of stem cells. In this...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703453/ https://www.ncbi.nlm.nih.gov/pubmed/34948411 http://dx.doi.org/10.3390/ijms222413615 |
_version_ | 1784621467208515584 |
---|---|
author | Chen, Lingye Hassani Nia, Fatemeh Stauber, Tobias |
author_facet | Chen, Lingye Hassani Nia, Fatemeh Stauber, Tobias |
author_sort | Chen, Lingye |
collection | PubMed |
description | Investigations on ion channels in muscle tissues have mainly focused on physiological muscle function and related disorders, but emerging evidence supports a critical role of ion channels and transporters in developmental processes, such as controlling the myogenic commitment of stem cells. In this review, we provide an overview of ion channels and transporters that influence skeletal muscle myoblast differentiation, cardiac differentiation from pluripotent stem cells, as well as vascular smooth muscle cell differentiation. We highlight examples of model organisms or patients with mutations in ion channels. Furthermore, a potential underlying molecular mechanism involving hyperpolarization of the resting membrane potential and a series of calcium signaling is discussed. |
format | Online Article Text |
id | pubmed-8703453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87034532021-12-25 Ion Channels and Transporters in Muscle Cell Differentiation Chen, Lingye Hassani Nia, Fatemeh Stauber, Tobias Int J Mol Sci Review Investigations on ion channels in muscle tissues have mainly focused on physiological muscle function and related disorders, but emerging evidence supports a critical role of ion channels and transporters in developmental processes, such as controlling the myogenic commitment of stem cells. In this review, we provide an overview of ion channels and transporters that influence skeletal muscle myoblast differentiation, cardiac differentiation from pluripotent stem cells, as well as vascular smooth muscle cell differentiation. We highlight examples of model organisms or patients with mutations in ion channels. Furthermore, a potential underlying molecular mechanism involving hyperpolarization of the resting membrane potential and a series of calcium signaling is discussed. MDPI 2021-12-19 /pmc/articles/PMC8703453/ /pubmed/34948411 http://dx.doi.org/10.3390/ijms222413615 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Lingye Hassani Nia, Fatemeh Stauber, Tobias Ion Channels and Transporters in Muscle Cell Differentiation |
title | Ion Channels and Transporters in Muscle Cell Differentiation |
title_full | Ion Channels and Transporters in Muscle Cell Differentiation |
title_fullStr | Ion Channels and Transporters in Muscle Cell Differentiation |
title_full_unstemmed | Ion Channels and Transporters in Muscle Cell Differentiation |
title_short | Ion Channels and Transporters in Muscle Cell Differentiation |
title_sort | ion channels and transporters in muscle cell differentiation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703453/ https://www.ncbi.nlm.nih.gov/pubmed/34948411 http://dx.doi.org/10.3390/ijms222413615 |
work_keys_str_mv | AT chenlingye ionchannelsandtransportersinmusclecelldifferentiation AT hassaniniafatemeh ionchannelsandtransportersinmusclecelldifferentiation AT staubertobias ionchannelsandtransportersinmusclecelldifferentiation |