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Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood

Poor linear growth is common in children with cystic fibrosis (CF) and predicts pulmonary status and mortality. Growth impairment develops in infancy, prior to pulmonary decline and despite aggressive nutritional measures. We hypothesized that growth restriction during early childhood in CF is assoc...

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Autores principales: Marks, Margaret P., Heltshe, Sonya L., Baines, Arthur, Ramsey, Bonnie W., Hoffman, Lucas R., Stalvey, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703459/
https://www.ncbi.nlm.nih.gov/pubmed/34959966
http://dx.doi.org/10.3390/nu13124414
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author Marks, Margaret P.
Heltshe, Sonya L.
Baines, Arthur
Ramsey, Bonnie W.
Hoffman, Lucas R.
Stalvey, Michael S.
author_facet Marks, Margaret P.
Heltshe, Sonya L.
Baines, Arthur
Ramsey, Bonnie W.
Hoffman, Lucas R.
Stalvey, Michael S.
author_sort Marks, Margaret P.
collection PubMed
description Poor linear growth is common in children with cystic fibrosis (CF) and predicts pulmonary status and mortality. Growth impairment develops in infancy, prior to pulmonary decline and despite aggressive nutritional measures. We hypothesized that growth restriction during early childhood in CF is associated with reduced adult height. We used the Cystic Fibrosis Foundation (CFF) patient registry to identify CF adults between 2011 and 2015 (ages 18–19 y, n = 3655) and had height for age (HFA) records between ages 2 and 4 y. We found that only 26% CF adults were ≥median HFA and 25% were <10th percentile. Between 2 and 4 years, those with height < 10th percentile had increased odds of being <10th percentile in adulthood compared to children ≥ 10th percentile (OR = 7.7). Of HFA measured between the 10th and 25th percentiles at ages 2–4, 58% were <25th percentile as adults. Only 13% between the 10th and 25th percentile HFA at age 2–4 years were >50th percentile as adults. Maximum height between ages 2 and 4 highly correlated with adult height. These results demonstrate that low early childhood CF height correlates with height in adulthood. Since linear growth correlates with lung growth, identifying both risk factors and interventions for growth failure (nutritional support, confounders of clinical care, and potential endocrine involvement) could lead to improved overall health.
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spelling pubmed-87034592021-12-25 Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood Marks, Margaret P. Heltshe, Sonya L. Baines, Arthur Ramsey, Bonnie W. Hoffman, Lucas R. Stalvey, Michael S. Nutrients Communication Poor linear growth is common in children with cystic fibrosis (CF) and predicts pulmonary status and mortality. Growth impairment develops in infancy, prior to pulmonary decline and despite aggressive nutritional measures. We hypothesized that growth restriction during early childhood in CF is associated with reduced adult height. We used the Cystic Fibrosis Foundation (CFF) patient registry to identify CF adults between 2011 and 2015 (ages 18–19 y, n = 3655) and had height for age (HFA) records between ages 2 and 4 y. We found that only 26% CF adults were ≥median HFA and 25% were <10th percentile. Between 2 and 4 years, those with height < 10th percentile had increased odds of being <10th percentile in adulthood compared to children ≥ 10th percentile (OR = 7.7). Of HFA measured between the 10th and 25th percentiles at ages 2–4, 58% were <25th percentile as adults. Only 13% between the 10th and 25th percentile HFA at age 2–4 years were >50th percentile as adults. Maximum height between ages 2 and 4 highly correlated with adult height. These results demonstrate that low early childhood CF height correlates with height in adulthood. Since linear growth correlates with lung growth, identifying both risk factors and interventions for growth failure (nutritional support, confounders of clinical care, and potential endocrine involvement) could lead to improved overall health. MDPI 2021-12-10 /pmc/articles/PMC8703459/ /pubmed/34959966 http://dx.doi.org/10.3390/nu13124414 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Marks, Margaret P.
Heltshe, Sonya L.
Baines, Arthur
Ramsey, Bonnie W.
Hoffman, Lucas R.
Stalvey, Michael S.
Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood
title Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood
title_full Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood
title_fullStr Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood
title_full_unstemmed Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood
title_short Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood
title_sort most short children with cystic fibrosis do not catch up by adulthood
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703459/
https://www.ncbi.nlm.nih.gov/pubmed/34959966
http://dx.doi.org/10.3390/nu13124414
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