Thymoquinone Inhibits Growth of Acute Myeloid Leukemia Cells through Reversal SHP-1 and SOCS-3 Hypermethylation: In Vitro and In Silico Evaluation

Epigenetic silencing of tumor suppressor genes (TSGs) plays an essential role in cancer pathogenesis, including acute myeloid leukemia (AML). All of SHP-1, SOCS-1, and SOCS-3 are TSGs that negatively regulate JAK/STAT signaling. Enhanced re-expression of TSGs through de-methylation represents a ther...

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Detalles Bibliográficos
Autores principales: Al-Rawashde, Futoon Abedrabbu, Johan, Muhammad Farid, Taib, Wan Rohani Wan, Ismail, Imilia, Johari, Syed Ahmad Tajudin Tuan, Almajali, Belal, Al-wajeeh, Abdullah Saleh, Nazari Vishkaei, Mansoureh, Al-Jamal, Hamid Ali Nagi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703481/
https://www.ncbi.nlm.nih.gov/pubmed/34959687
http://dx.doi.org/10.3390/ph14121287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703481/
https://www.ncbi.nlm.nih.gov/pubmed/34959687
http://dx.doi.org/10.3390/ph14121287

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