Overdose of Quetiapine—A Case Report with QT Prolongation

Quetiapine is an atypical antipsychotic drug used to treat bipolar disorder, schizophrenia, and major depressive disorder. Although several studies describe the adverse effects of intoxication with Quetiapine, only a few report an extreme overdose without comedications that lead to a life threat. We...

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Autores principales: Bertol, Elisabetta, Vaiano, Fabio, Argo, Antonina, Zerbo, Stefania, Trignano, Claudia, Protani, Simone, Favretto, Donata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703483/
https://www.ncbi.nlm.nih.gov/pubmed/34941773
http://dx.doi.org/10.3390/toxics9120339
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author Bertol, Elisabetta
Vaiano, Fabio
Argo, Antonina
Zerbo, Stefania
Trignano, Claudia
Protani, Simone
Favretto, Donata
author_facet Bertol, Elisabetta
Vaiano, Fabio
Argo, Antonina
Zerbo, Stefania
Trignano, Claudia
Protani, Simone
Favretto, Donata
author_sort Bertol, Elisabetta
collection PubMed
description Quetiapine is an atypical antipsychotic drug used to treat bipolar disorder, schizophrenia, and major depressive disorder. Although several studies describe the adverse effects of intoxication with Quetiapine, only a few report an extreme overdose without comedications that lead to a life threat. We present a case of a 75-year-old male who tried to attempt suicide by ingesting 28 g of Quetiapine. During the management in the emergency department, both serum and urine samples were collected, allowing a complete pharmacokinetic analysis to be conducted, from the admission to the discharge.
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spelling pubmed-87034832021-12-25 Overdose of Quetiapine—A Case Report with QT Prolongation Bertol, Elisabetta Vaiano, Fabio Argo, Antonina Zerbo, Stefania Trignano, Claudia Protani, Simone Favretto, Donata Toxics Case Report Quetiapine is an atypical antipsychotic drug used to treat bipolar disorder, schizophrenia, and major depressive disorder. Although several studies describe the adverse effects of intoxication with Quetiapine, only a few report an extreme overdose without comedications that lead to a life threat. We present a case of a 75-year-old male who tried to attempt suicide by ingesting 28 g of Quetiapine. During the management in the emergency department, both serum and urine samples were collected, allowing a complete pharmacokinetic analysis to be conducted, from the admission to the discharge. MDPI 2021-12-07 /pmc/articles/PMC8703483/ /pubmed/34941773 http://dx.doi.org/10.3390/toxics9120339 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Bertol, Elisabetta
Vaiano, Fabio
Argo, Antonina
Zerbo, Stefania
Trignano, Claudia
Protani, Simone
Favretto, Donata
Overdose of Quetiapine—A Case Report with QT Prolongation
title Overdose of Quetiapine—A Case Report with QT Prolongation
title_full Overdose of Quetiapine—A Case Report with QT Prolongation
title_fullStr Overdose of Quetiapine—A Case Report with QT Prolongation
title_full_unstemmed Overdose of Quetiapine—A Case Report with QT Prolongation
title_short Overdose of Quetiapine—A Case Report with QT Prolongation
title_sort overdose of quetiapine—a case report with qt prolongation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703483/
https://www.ncbi.nlm.nih.gov/pubmed/34941773
http://dx.doi.org/10.3390/toxics9120339
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