Cargando…

High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films

Surface plasmon resonance (SPR) biosensors consisting of alternate layers of silver (Ag) and TiO(2) thin film have been proposed as a high sensitivity biosensor. The structure not only prevents the Ag film from oxidation, but also enhances the field inside the structure, thereby improving the perfor...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Haoyuan, Shan, Shihan, Wang, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703543/
https://www.ncbi.nlm.nih.gov/pubmed/34947748
http://dx.doi.org/10.3390/nano11123399
_version_ 1784621488880484352
author Cai, Haoyuan
Shan, Shihan
Wang, Xiaoping
author_facet Cai, Haoyuan
Shan, Shihan
Wang, Xiaoping
author_sort Cai, Haoyuan
collection PubMed
description Surface plasmon resonance (SPR) biosensors consisting of alternate layers of silver (Ag) and TiO(2) thin film have been proposed as a high sensitivity biosensor. The structure not only prevents the Ag film from oxidation, but also enhances the field inside the structure, thereby improving the performance of the sensor. Genetic algorithm (GA) was used to optimize the proposed structure and its maximum angular sensitivity was 384°/RIU (refractive index unit) at the refractive index environment of 1.3425, which is about 3.12 times that of the conventional Ag-based biosensor. A detailed discussion, based on the finite difference time domain (FDTD) method, revealed that an enhanced evanescent field at the top layer–analyte region results in the ultra-sensitivity characteristic. We expect that the proposed structure can be a suitable biosensor for chemical detection, clinical diagnostics, and biological examination.
format Online
Article
Text
id pubmed-8703543
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87035432021-12-25 High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films Cai, Haoyuan Shan, Shihan Wang, Xiaoping Nanomaterials (Basel) Article Surface plasmon resonance (SPR) biosensors consisting of alternate layers of silver (Ag) and TiO(2) thin film have been proposed as a high sensitivity biosensor. The structure not only prevents the Ag film from oxidation, but also enhances the field inside the structure, thereby improving the performance of the sensor. Genetic algorithm (GA) was used to optimize the proposed structure and its maximum angular sensitivity was 384°/RIU (refractive index unit) at the refractive index environment of 1.3425, which is about 3.12 times that of the conventional Ag-based biosensor. A detailed discussion, based on the finite difference time domain (FDTD) method, revealed that an enhanced evanescent field at the top layer–analyte region results in the ultra-sensitivity characteristic. We expect that the proposed structure can be a suitable biosensor for chemical detection, clinical diagnostics, and biological examination. MDPI 2021-12-15 /pmc/articles/PMC8703543/ /pubmed/34947748 http://dx.doi.org/10.3390/nano11123399 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cai, Haoyuan
Shan, Shihan
Wang, Xiaoping
High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films
title High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films
title_full High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films
title_fullStr High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films
title_full_unstemmed High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films
title_short High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films
title_sort high sensitivity surface plasmon resonance sensor based on periodic multilayer thin films
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703543/
https://www.ncbi.nlm.nih.gov/pubmed/34947748
http://dx.doi.org/10.3390/nano11123399
work_keys_str_mv AT caihaoyuan highsensitivitysurfaceplasmonresonancesensorbasedonperiodicmultilayerthinfilms
AT shanshihan highsensitivitysurfaceplasmonresonancesensorbasedonperiodicmultilayerthinfilms
AT wangxiaoping highsensitivitysurfaceplasmonresonancesensorbasedonperiodicmultilayerthinfilms